A transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in xenograft tumors

2008 ◽  
Vol 368 (2) ◽  
pp. 364-367 ◽  
Author(s):  
Femke Hillen ◽  
Eric L. Kaijzel ◽  
Karolien Castermans ◽  
Mirjam G.A. oude Egbrink ◽  
Clemens W.G.M. Löwik ◽  
...  
Keyword(s):  
Mouse Model ◽  
Vascular Biology ◽  
Athymic Mouse

Limitations of studying keloid scars using the nude athymic mouse model

2002 ◽  
Vol 10 (2) ◽  
pp. 56-61 ◽  
Author(s):  
Mp Hillmer ◽  
S Salama ◽  
Sm Macleod
Keyword(s):  
Mouse Model ◽  
Scar Tissue ◽  
In Vivo Studies ◽  
Athymic Mice ◽  
Athymic Mouse ◽  
Tissue Samples ◽  
Keloid Scars ◽  
Central Calcification ◽  
Sample Identity

Keloid scars are benign fibroproliferative growths that respond poorly to treatment. This study sought to determine the efficacy of three different glucocorticoids (triamcinolone, methylprednisolone and dexamethasone) in altering human keloid scar tissue implanted in athymic mice. Keloid tissue obtained from three patients (one man and two women) who sought cosmetic removal of their scars was implanted into athymic mice for a duration of 15 or 30 days. The keloid tissue was examined histopathologically and evaluated by a dermatopathologist who was blinded to sample identity and who was using predetermined qualitative scoring criteria. The appearance of central calcification, granulation tissue, foreign body granulomatous reaction and acute inflammatory reaction complicated the comparison of the keloid tissue samples. However, on the basis of observations reported in the present paper, it appears that triamcinolone should remain the treatment of choice for keloid scars. The athymic mouse model that is used for studying keloid scars is the best available approach to in vivo studies; however, limitations identified in this study confound the interpretation of experimental data. Ideally, promising and novel therapies should be investigated clinically.

Human breast tumor imaging using 111In labeled monoclonal antibody: Athymic mouse model

1988 ◽  
Vol 14-14 (7-8) ◽  
Author(s):  
BanAn Khaw ◽  
JosephS. Bailes ◽  
SandraL. Schneider ◽  
Jack Lancaster ◽  
James Powers ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Mouse Model ◽  
Breast Tumor ◽  
Tumor Imaging ◽  
Athymic Mouse ◽  
Human Breast ◽  
Human Breast Tumor

Single-Cell Suspensions of Cultured Human Keratinocytes in Fibrin–Glue Reconstitute the Epidermis

1998 ◽  
Vol 7 (3) ◽  
pp. 309-317 ◽  
Author(s):  
Raymund E. Horch ◽  
Holger Bannasch ◽  
Jürgen Kopp ◽  
Christoph Andree ◽  
G. Björn Stark
Keyword(s):  
Electron Microscopy ◽  
Mouse Model ◽  
Fibrin Glue ◽  
Single Cells ◽  
Human Keratinocytes ◽  
New Technique ◽  
Junction Zone ◽  
Full Thickness ◽  
Athymic Mouse ◽  
A New Technique

To overcome common disadvantages of standard cultured epidermal sheet grafts (CEG) we have developed a new technique of transplanting cultured human keratinocytes suspended as single cells in a fibrin–glue matrix (Keratinocyte–fibrin–glue suspension—KFGS). In an athymic mouse model with reproducible standardized full thickness wounds this new technique was compared directly to CEG. Reepithelialization was similar in both groups, but reconstitution of the dermo-epidermal junction zone, as shown by electron microscopy and immunohistochemistry was significantly enhanced by the fibrin–glue suspension technique. The new KFGS technique is earlier available than sheet grafts, is able to transfer actively proliferative single keratinocytes, and simplifies the application.

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