Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity

2006 ◽  
Vol 350 (1) ◽  
pp. 162-168 ◽  
Author(s):  
Jinrong Fu ◽  
Guosheng Lin ◽  
Bin Zeng ◽  
Zhiwei Wu ◽  
Yanxia Wu ◽  
...  
Keyword(s):  
Cell Injury ◽  
Ischemia Reperfusion ◽  
Myocardial Cell ◽  
C1 Inhibitor ◽  
Myocardial Cell Injury

Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury

2006 ◽  
Vol 349 (2) ◽  
pp. 504-512 ◽  
Author(s):  
Jinrong Fu ◽  
Guosheng Lin ◽  
Zhiwei Wu ◽  
Bin Ceng ◽  
Yanxia Wu ◽  
...  
Keyword(s):  
Cell Injury ◽  
Ischemia Reperfusion ◽  
Myocardial Cell ◽  
C1 Inhibitor ◽  
Myocardial Cell Injury

Anti-apoptotic Potency of TNFR:Fc Gene in Ischemia/Reperfusion-Induced Myocardial Cell Injury

Inflammation ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 664-671 ◽  
Author(s):  
Jun Guo ◽  
Dong Zheng ◽  
Hai-Rui Li ◽  
Ai-Dong Zhang ◽  
Zi-Cheng Li
Keyword(s):  
Cell Injury ◽  
Ischemia Reperfusion ◽  
Myocardial Cell ◽  
Myocardial Cell Injury

scholarly journals Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice

Physiology ◽  
2000 ◽  
Vol 15 (6) ◽  
pp. 303-308
Author(s):  
Steven P. Jones ◽  
David J. Lefer
Keyword(s):  
Reperfusion Injury ◽  
Cell Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cell Types ◽  
Myocardial Cell ◽  
Myocardial Cell Injury ◽  
Multiple Cell ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

Myocardial ischemia-reperfusion injury involves activation of multiple cell types, including leukocytes and endothelial cells. The pursuant inflammation involves diminished nitric oxide production, influx of neutrophils, and myocardial cell injury. Gene-targeted animals provide important clues about the progression of this inflammatory cascade.

scholarly journals Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Lihua Fan ◽  
Deyuan Chen ◽  
Jianping Wang ◽  
Yini Wu ◽  
Dongli Li ◽  
...  
Keyword(s):  
Light Chain ◽  
Cell Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Myocardial Cell ◽  
The Other ◽  
Sirtuin 1 ◽  
Rat Models ◽  
Myocardial Cell Injury ◽  
Potential Option

Misfolded and aberrant proteins have been found to be associated with myocardial cell injury. Thus, increased clearance of misfolded or aggregated proteins via autophagy might be a potential option in preventing myocardial cell injury. Sevoflurane may ameliorate myocardial cell injury by affecting sirtuin 1- (SIRT1-) mediated autophagy. Rat models with myocardial cell injury were induced by limb ischemia reperfusion. The model rats received different treatments: sevoflurane, nicotinamide, and autophagy inhibitor 3-methyladenine (3-MA). Autophagy was observed by SEM. The levels of SIRT1 and microtubule-associated protein 1A/1B-light chain 3 (LC3) were measured. Present findings demonstrated that limb ischemia reperfusion induced autophagy. Sevoflurane increased the level of SIRT1, which deacetylated LC3 and further increased autophagic rates. On the other hand, the autophagy was inhibited by sevoflurane and or the inhibitors of SIRT1 and LC3. Present results demonstrated a novel molecular mechanism by which sevoflurane induced autophagy by increasing the level of SIRT1 and reducing the acetylation of LC3.

scholarly journals Perioperative myocardial cell injury: the role of troponins

1997 ◽  
Vol 78 (4) ◽  
pp. 386-390 ◽  
Author(s):  
H Metzler ◽  
M Gries ◽  
P Rehak ◽  
T Lang ◽  
S Fruhwald ◽  
...  
Keyword(s):  
Cell Injury ◽  
Myocardial Cell ◽  
Myocardial Cell Injury

Cytosolic Free Calcium and Myocardial Cell Injury

1988 ◽  
pp. 413-420 ◽  
Author(s):  
E. Murphy ◽  
C. Steenbergen ◽  
A. LeFurgey ◽  
M. Lieberman ◽  
R. E. London
Keyword(s):  
Cell Injury ◽  
Myocardial Cell ◽  
Free Calcium ◽  
Cytosolic Free Calcium ◽  
Myocardial Cell Injury
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