Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia/reperfusion injury in rat liver

2006 ◽  
Vol 349 (3) ◽  
pp. 1087-1093 ◽  
Author(s):  
Woo-Yong Lee ◽  
Sun-Mee Lee
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion

Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver

2009 ◽  
Vol 209 (3) ◽  
pp. S16
Author(s):  
Gokulakkrishna Subhas ◽  
Aditya Gupta ◽  
Daniel Bakston ◽  
Boris Silberberg ◽  
Catherine Lobocki ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Warm Ischemia

scholarly journals Role of Remote Ischemic Preconditioning in Hepatic Ischemic Reperfusion Injury

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582094692
Author(s):  
Eun Kyung Choi ◽  
Hoon Jung ◽  
Sungmin Jeon ◽  
Jung A. Lim ◽  
Jungwon Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Inflammatory Cytokines ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Remote Ischemic Preconditioning ◽  
Hepatic Tissue ◽  
Hepatic Ischemia

The effect of remote ischemic preconditioning (RIPC) has been proposed that mediates the protective response in ischemia reperfusion injury (IRI) of various organs. In this study, we investigated the effect of RIPC in hepatic IRI, by assessing biomarker of oxidative stress and inflammatory cytokines. Moreover, we intended to demonstrate any such protective effect through nitric oxide (NO). Twenty-five rats were divided into the 5 groups: (1) Sham; (2) RIPC; (3) hepatic IRI; (4) RIPC + hepatic IRI; (5) C-PTIO, 2-(4-carboxyphenyl)-4,5dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3oxide, + RIPC + hepatic IRI. RIPC downregulated the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), histologic damage, and activity of Malondialdehyde (MDA). However, there was no significant reduction in the level of tumor necrosis factor-alpha (TNF-α) and nuclear factor kappa B (NF-κB). AST and ALT levels, and hepatic tissue morphology in the C-PTIO group showed a significant improvement compared to those of the RIPC + hepatic IRI group. The application of RIPC before hepatic ischemia downregulated the oxidative stress, not the inflammatory cytokines. Moreover, these protective effect of RIPC would be mediated through the activation of NO as well as anti-oxidant effect.

Protective effect of UDCA on rat liver against ischemia/reperfusion injury

2003 ◽  
Vol 38 ◽  
pp. 43
Author(s):  
G. Nowak ◽  
U. Noren ◽  
H.-U. Marschall ◽  
L. Moller ◽  
A. Wernerson ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion
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