A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice

2006 ◽  
Vol 347 (4) ◽  
pp. 949-954 ◽  
Author(s):  
Masaru Odashima ◽  
Michiro Otaka ◽  
Mario Jin ◽  
Youhei Horikawa ◽  
Tamotsu Matsuhashi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Concanavalin A ◽  
Receptor Agonist ◽  
Acute Liver Injury ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Polydeoxyribonucleotide Exerts Protective Effect Against CCl4-Induced Acute Liver Injury Through Inactivation of NF-κB/MAPK Signaling Pathway in Mice

2020 ◽  
Vol 21 (21) ◽  
pp. 7894 ◽  
Author(s):  
Il-Gyu Ko ◽  
Jun-Jang Jin ◽  
Lakkyong Hwang ◽  
Sang-Hoon Kim ◽  
Chang-Ju Kim ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Inflammatory Cytokines ◽  
Intraperitoneal Injection ◽  
Acute Liver Injury ◽  
Adenosine A2a Receptor ◽  
Liver Index ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Pro Inflammatory Cytokines

Acute liver injury (ALI) causes life-threatening clinical problem, and its underlying etiology includes inflammation and apoptosis. An adenosine A2A receptor agonist, polydeoxyribonucleotide (PDRN), exhibits anti-inflammatory and anti-apoptotic effects by inhibiting the secretion of pro-inflammatory cytokines. In the current study, the protective effect of PDRN against carbon tetrachloride (CCl4)-induced ALI was investigated using mice. For the induction of ALI, mice received intraperitoneal injection of CCl4 twice over seven days. Mice from the PDRN-treated groups received an intraperitoneal injection of 200 μL saline containing PDRN (8 mg/kg), once a day for seven days, starting on day 1 after the first CCl4 injection. In order to confirm that the action of PDRN occurs through the adenosine A2A receptor, 8 mg/kg 3,7-dimethyl-1-propargylxanthine (DMPX), an adenosine A2A receptor antagonist, was treated with PDRN. Administration of CCl4 impaired liver tissue and increased the liver index and histopathologic score. The expression of pro-inflammatory cytokines was increased, and apoptosis was induced by the administration of CCl4. Administration of CCl4 activated nuclear factor-kappa B (NF-κB) and facilitated phosphorylation of signaling factors in mitogen-activated protein kinase (MAPK). In contrast, PDRN treatment suppressed the secretion of pro-inflammatory cytokines and inhibited apoptosis. PDRN treatment inactivated NF-κB and suppressed phosphorylation of signaling factors in MAPK. As a result, liver index and histopathologic score were reduced by PDRN treatment. When PDRN was treated with DMPX, the anti-inflammatory and anti-apoptotic effect of PDRN disappeared. Therefore, PDRN can be used as an effective therapeutic agent for acute liver damage.

scholarly journals The Diameter of Retinal Arterioles Is Unaffected by Intravascular Administration of the Adenosine A2A Receptor Agonist Regadenoson in Normal Persons

2019 ◽  
Vol 4 (2) ◽  
pp. 1-10 ◽  
Author(s):  
Anna Dons-Jensen ◽  
Line Petersen ◽  
Hans-Erik Bøtker ◽  
Toke Bek
Keyword(s):  
Intravenous Administration ◽  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
Retinal Vessels ◽  
Adenosine Receptor Agonists ◽  
Retinal Arterioles ◽  
A2a Receptor ◽  
Adenosine A2a

Background: The neurotransmitter adenosine has been proposed to be involved in the pathogenesis of diabetic retinopathy, which may be due to the vasoactive properties of the compound. Previous studies have shown that adenosine can affect the tone of retinal arterioles in vitro to induce dilatation mediated by A2A and A2Breceptors and constriction mediated by A1 and A3 receptors. Purpose: To investigate effects of intravenous administration of the adenosine A2A receptor agonist regadenoson on the diameter of retinal vessels in vivo. Method: The diameter responses of larger retinal arterioles and venules were evaluated using the dynamic vessel analyser in 20 normal persons (age 22–31 years) after intravenous administration of the adenosine A2A receptor agonist regadenoson during exposure to systemic normoxia and hypoxia. Results: The diameter of retinal arterioles and venules increased significantly during stimulation with flickering light (p < 0.0001). Regadenoson reduced the flicker-induced dilatation of venules during normoxia (p = 0.0006), but otherwise had no effect on vessel diameters (p > 0.08 for all comparisons). Conclusions:Intravenous administration of the adenosine A2A receptor agonist regadenoson had no significant effect on the diameter of retinal arterioles. Future studies should investigate differential effects of intra- and extravascular administration of adenosine receptor agonists on retinal vessels.

Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat

2002 ◽  
Vol 438 (3) ◽  
pp. 183-188 ◽  
Author(s):  
John R Fozard ◽  
Karen M Ellis ◽  
Maria F Villela Dantas ◽  
Bruno Tigani ◽  
Lazzaro Mazzoni
Keyword(s):  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
Cgs 21680 ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Airways Inflammation

Effects of adenosine A2a receptor agonist and antagonist on hippocampal nuclear factor-kB expression preceded by MDMA toxicity

2012 ◽  
Vol 28 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Fatemeh Kermanian ◽  
Mansooreh Soleimani ◽  
Alireza Ebrahimzadeh ◽  
Hossein Haghir ◽  
Mehdi Mehdizadeh
Keyword(s):  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
Nuclear Factor ◽  
A2a Receptor ◽  
Agonist And Antagonist ◽  
Adenosine A2a ◽  
Nuclear Factor Kb

ChemInform Abstract: The Synthesis and Biological Activity of a Highly Selective Adenosine A2a Receptor Agonist.

ChemInform ◽  
2010 ◽  
Vol 31 (10) ◽  
pp. no-no
Author(s):  
David R. Borcherding ◽  
Nelsen L. Lentz ◽  
Philip M. Weintraub ◽  
Mark W. Dudley ◽  
Roberta Secrest ◽  
...  
Keyword(s):  
Biological Activity ◽  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195047 ◽  
Author(s):  
Allan K. Alencar ◽  
Fábio I. Carvalho ◽  
Ananssa M. Silva ◽  
Sabrina T. Martinez ◽  
Jorge A. Calasans-Maia ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Receptor Agonist ◽  
Pde5 Inhibitor ◽  
Adenosine A2a Receptor ◽  
Synergistic Interaction ◽  
A2a Receptor ◽  
Adenosine A2a

Coronary Circulation Responses to Binodenoson, a Selective Adenosine A2A Receptor Agonist

2007 ◽  
Vol 99 (11) ◽  
pp. 1507-1512 ◽  
Author(s):  
John McB. Hodgson ◽  
Nabil Dib ◽  
Morton J. Kern ◽  
Richard G. Bach ◽  
Richard J. Barrett
Keyword(s):  
Receptor Agonist ◽  
Coronary Circulation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

2017 ◽  
Vol 07 ◽  
Author(s):  
Francesco Squadrito ◽  
Antonio Micali ◽  
Mariagrazia Rinaldi ◽  
Natasha Irrera ◽  
Herbert Marini ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Blood Testis Barrier
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