Effects of Cacna1c haploinsufficiency on social interaction behavior and 50-kHz ultrasonic vocalizations in adult female rats

2019 ◽  
Vol 367 ◽  
pp. 35-52 ◽  
Author(s):  
Tobias M. Redecker ◽  
Theresa M. Kisko ◽  
Rainer K.W. Schwarting ◽  
Markus Wöhr
Keyword(s):  
Social Interaction ◽  
Adult Female ◽  
Ultrasonic Vocalizations ◽  
Female Rats ◽  
Interaction Behavior

CORTICOSTEROID-UMSATZ UND CORTICOSTEROID-PRODUKTION BEI RATTEN UNTER DER BEHANDLUNG MIT ANABOLEN STEROIDEN

1965 ◽  
Vol 48 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Herbert Schriefers ◽  
Gerlinde Scharlau ◽  
Franzis Pohl
Keyword(s):  
Production Rate ◽  
Adult Female ◽  
Anabolic Steroids ◽  
Reduction Rate ◽  
Female Rats ◽  
Adrenal Weight ◽  
Hydrogenase Activity ◽  
Anabolic Effect ◽  
Liver Slices

ABSTRACT After the administration of anabolic steroids to adult female rats in daily doses of 1 mg per animal for 14 days, the following parameters were investigated: the rate of the Δ4-5α-hydrogenase-catalyzed cortisone reduction in liver slices and microsomal fractions, the adrenal weight and the in vitro corticosterone production rate. Among the steroids tested, only 17α-methyl-testosterone and 17α-ethyl-19-nor-testosterone were effective in lowering significantly cortisone reduction rate by liver slices with concomitant decreases in microsomal Δ4-5α-hydrogenase-activity. Testosterone, 19-nor-testosterone, 17α-ethinyl-19-nor-testosterone, 17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one and 1-methyl-17β-hydroxy-androst-1-en-3-one were ineffective or only slightly effective. Adrenal weight and absolute corticosterone production rate (μg/60 min per animal) were decreased after treatment with 17α-methyl-testosterone, 17α-ethyl-19-nor-testosterone and 1-methyl-17β-hydroxy-androst-1-en-3-one. Corticosterone production was decreased with 17α-ethinyl-19-nor-testosterone in spite of an unchanged adrenal weight. The relative corticosterone production rate (μg/60 min · 100 mg adrenal) was in any cases unaffected. According to these results there exists – with the exception of 17α-ethinyl-19-nor-testosterone – a strict parallelism between corticosteroid turnover and corticosterone production rate: unchanged turnover is correlated with unchanged corticosterone production rate, while a decreased turnover is correlated with decreased adrenal activity. The protein-anabolic effect of certain anabolic steroids may be partly due to an anti-catabolic action of these compounds resulting from a decreased corticosteroid inactivation and production rate. Possible mechanisms by which anabolic steroids may affect corticosteroid-balance are discussed.

THE HYPOTHALAMUS AND PROPYLTHIOURACIL-INDUCED GOITRE IN THE RAT

1963 ◽  
Vol 42 (2) ◽  
pp. 254-262 ◽  
Author(s):  
J. J. van der Werff ten Bosch ◽  
H. E. Swanson
Keyword(s):  
Steady State ◽  
Thyroid Hormone ◽  
Adult Female ◽  
Normal Diet ◽  
Anterior Hypothalamus ◽  
Female Rats ◽  
Intact Rats

ABSTRACT Adult female rats were given a normal diet, or a diet which contained 0.15% propylthiouracil. At the beginning of the experiment one half of the rats were left intact, whilst the others received an electrolytic basal midline lesion in the anterior hypothalamus. Of each of the four groups of rats, one half was killed after 14 days, the others after 28 days. It was found (both after 14 and after 28 days) that the presence of a lesion reduced the thyroid weight to approximately 75% of the value in intact rats on the same diet, which might be normal or contain propylthiouracil. Propylthiouracil caused thyroid enlargement (to 278% after 14 days and 352–360% after 28 days) in intact rats as compared with intact rats on a normal diet, and in lesioned rats as compared with lesioned rats on a normal diet. It is concluded that lesions cause a lowered steady state of the thyroid-pituitary feed-back system, but that this system responds normally to the alteration of the steady state caused by the propylthiouracil-induced block in thyroid hormone output.

BEFUNDE AM GENITALTRAKTUS DER RATTE NACH CORTICOTROPIN-INJECTION UND IHRE DEUTUNG UNTER BERÜCKSICHTIGUNG DES ZELLBILDES DER ADENOHYPOPHYSE

1959 ◽  
Vol XXXII (II) ◽  
pp. 167-176 ◽  
Author(s):  
Walter Schätzle
Keyword(s):  
Adult Female ◽  
Single Injection ◽  
Anterior Lobe ◽  
Vaginal Epithelium ◽  
Female Rats ◽  
Normal Adult ◽  
List Type

ABSTRACT In normal adult female rats a single injection of 5 IU corticotrophin was followed by a retention of glucoproteid material in the anterior lobe of the hypophysis and by impairment of the luteinization. In spayed adult female rats the same corticotrophin administration caused stratification and mucification of the vaginal epithelium.

Supporting Youth With Autism Learning Social Competence: A Comparison of Game- and Nongame-Based Activities in 3D Virtual World

2021 ◽  
pp. 073563312110220
Author(s):  
Xianhui Wang ◽  
Wanli Xing
Keyword(s):  
Social Interaction ◽  
Social Competence ◽  
Central Element ◽  
Autism Spectrum ◽  
Virtual Learning Environment ◽  
Learning Activities ◽  
Behavior Patterns ◽  
Interaction Behavior ◽  
Significant Difference ◽  
The Impact

This study explored youth with Autism Spectrum Disorder (ASD) learning social competence in the context of innovative 3D virtual learning environment and the effects of gaming as a central element of the learning experience. The empirical study retrospectively compared the social interactions of 11 adolescents with ASD in game-and nongame-based 3D collaborative learning activities in the same social competence training curriculum. We employed a learning analytics approach - association rule mining to uncover the associative rules of verbal social interaction and nonverbal social interaction contributors from the large dataset of the coded social behaviors. By comparing the rules across the game and nongame activities, we found a significant difference in youth with ASD’s social performance. The results of the group comparison study indicated that the co-occurrence of verbal and nonverbal behaviors is much stronger in the game-based learning activities. The game activities also yielded more diverse social interaction behavior patterns. On the other hand, in the nongame activities, students’ social interaction behavior patterns are much more limited. Furthermore, the impact of game design principles on learning is then discussed in this paper.

Eugenol improves tissue damage and oxidative stress in adult female rats after ovarian torsion/detorsion

2021 ◽  
pp. 1-6
Author(s):  
Bita Barghi ◽  
Majid Shokoohi ◽  
Amir Afshin Khaki ◽  
Arash Khaki ◽  
Maryam Moghimian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
Tissue Damage ◽  
Ovarian Torsion ◽  
Female Rats ◽  
And Oxidative Stress

scholarly journals Adult female rats perinatally exposed to perfluorohexane sulfonate (PFHxS) and a mixture of endocrine disruptors display increased body/fat weights without a transcriptional footprint in fat cells

2021 ◽  
Vol 339 ◽  
pp. 78-87
Author(s):  
Cecilie Nethe Ramskov Tetzlaff ◽  
Louise Ramhøj ◽  
Aurélie Lardenois ◽  
Marta Axelstad ◽  
Bertrand Evrard ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Body Fat ◽  
Adult Female ◽  
Female Rats ◽  
Fat Cells

scholarly journals Electro-acupuncture improves the social interaction behavior of rats

2015 ◽  
Vol 151 ◽  
pp. 485-493 ◽  
Author(s):  
Hong-Feng Zhang ◽  
Han-Xia Li ◽  
Yu-Chuan Dai ◽  
Xin-Jie Xu ◽  
Song-Ping Han ◽  
...  
Keyword(s):  
Social Interaction ◽  
Interaction Behavior ◽  
The Social ◽  
Behavior Of Rats
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