Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease

2018 ◽  
Vol 337 ◽  
pp. 256-263 ◽  
Author(s):  
T.P. O’Leary ◽  
A. Robertson ◽  
P.H. Chipman ◽  
V.F. Rafuse ◽  
R.E. Brown
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Motor Function ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

scholarly journals Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 14 ◽  
Author(s):  
Jeremiah K. H. Lim ◽  
Qiao-Xin Li ◽  
Zheng He ◽  
Algis J. Vingrys ◽  
Holly R. Chinnery ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Structural Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

Exercise‐Induced Alterations in TrkB expression in the 5XFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Christopher Moylan ◽  
Thanh Vinh Cao ◽  
Quy‐Susan Huynh ◽  
Anishchal Pratap ◽  
R. M. Damian Holsinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse ◽  
Exercise Induced

Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Fanglei Han ◽  
Jia Zhao ◽  
Guoqing Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Volatile Anesthetics ◽  
Model Of Alzheimer’S Disease ◽  
Short Term Exposure ◽  
5Xfad Mouse ◽  
Anesthetic Exposure ◽  
5Xfad Mice

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which shows a set of symptoms involving cognitive changes and psychological changes. Given that AD is the most common form of dementia in aging population and the increasing demand for anesthesia/surgery with aging, there has been significant interest in the exact impact of volatile anesthetics on cognitive function and pathological alterations in AD population. Objective: This study aimed to investigate behavioral changes and neuropathology in the 5xFAD mouse model of Alzheimer’s disease with short-term exposure or long-term exposure to desflurane, sevoflurane, or isoflurane. Methods: In this study, we exposed 5xFAD mouse model of AD to isoflurane, sevoflurane, or desflurane in two different time periods (30 min and 6 h), and the memory related behaviors as well as the pathological changes in 5xFAD mice were evaluated 7 days after the anesthetic exposure. Results: We found that short-term exposure to volatile anesthetics did not affect hippocampus dependent memory and the amyloid-β (Aβ) deposition in the brain. However, long-term exposure to sevoflurane or isoflurane significantly increased the Aβ deposition in CA1 and CA3 regions of hippocampus, as well as the glial cell activation in amygdala. Besides, the PSD-95 expression was decreased in 5xFAD mice with exposure to sevoflurane or isoflurane and the caspase-3 activation was enhanced in isoflurane, sevoflurane, and desflurane groups. Conclusion: Our results demonstrate the time-dependent effects of common volatile anesthetics and implicate that desflurane has the potential benefits to prolonged anesthetic exposure in AD patients.

scholarly journals Effect of transthyretin gene therapy in the 5XFAD mouse model of Alzheimer’s disease

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Ana Rita Batista ◽  
Paola Rodriguez ◽  
Monique Otero ◽  
Robert M. King ◽  
Matthew J. Gounis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Therapy ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

scholarly journals Analysis of Motor Function in the Tg4-42 Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 13 ◽  
Author(s):  
Jannek M. Wagner ◽  
Marius E. Sichler ◽  
Eva M. Schleicher ◽  
Timon N. Franke ◽  
Caroline Irwin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Motor Function ◽  
Model Of Alzheimer’S Disease
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