Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function

2017 ◽  
Vol 316 ◽  
pp. 115-124 ◽  
Author(s):  
Rojin Sharif ◽  
Mehdi Aghsami ◽  
Mehdi Gharghabi ◽  
Mehdi Sanati ◽  
Tina Khorshidahmad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spatial Memory ◽  
Mitochondrial Function ◽  
Memory Deficit ◽  
Spatial Memory Deficit

scholarly journals Effects of mercuric chloride on spatial memory deficit-induced by beta-amyloid and evaluation of mitochondrial function markers in the hippocampus of rats

Metallomics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 144-153
Author(s):  
Ladan Behzadfar ◽  
Shokoufeh Hassani ◽  
Hossein Feizpour ◽  
Nakisa Abbasian ◽  
Armin Salek Maghsoudi ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Spatial Memory ◽  
Mercuric Chloride ◽  
Mitochondrial Function ◽  
Beta Amyloid ◽  
Memory Deficit ◽  
Spatial Memory Deficit

Mercury is a highly poisonous heavy metal abundantly found in the environment in its inorganic form.

Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress

2019 ◽  
Vol 1710 ◽  
pp. 74-81 ◽  
Author(s):  
Md. Mamun Al-Amin ◽  
Waich Mahmud ◽  
Mst. Shahnaj Pervin ◽  
S.M. Ridwanul Islam ◽  
Muhammad Ashikur Rahman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spatial Memory ◽  
Memory Deficit ◽  
Spatial Memory Deficit

Potentiating role of copper on spatial memory deficit induced by beta amyloid and evaluation of mitochondrial function markers in the hippocampus of rats

Metallomics ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 969-980 ◽  
Author(s):  
Ladan Behzadfar ◽  
Mohammad Abdollahi ◽  
Omid Sabzevari ◽  
Rohollah Hosseini ◽  
Ahmad Salimi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Function ◽  
Chronic Administration ◽  
Beta Amyloid ◽  
Memory Deficit ◽  
Spatial Memory Deficit

The mechanistic relation between mitochondrial dysfunction and memory deficit caused by chronic administration of copper alone and in combination with Aβ.

scholarly journals Alleviation of Memory Deficit by Bergenin via the Regulation of Reelin and Nrf-2/NF-κB Pathway in Transgenic Mouse Model

2021 ◽  
Vol 22 (12) ◽  
pp. 6603
Author(s):  
Bushra Shal ◽  
Adnan Khan ◽  
Ashraf Ullah Khan ◽  
Rahim Ullah ◽  
Gowhar Ali ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Neuroprotective Effect ◽  
Annexin V ◽  
Memory Deficit ◽  
Y Maze ◽  
Spatial Memory Deficit ◽  
Aβ Aggregation ◽  
Ft Ir ◽  
Reelin Signaling

The present study aims to determine the neuroprotective effect of Bergenin against spatial memory deficit associated with neurodegeneration. Preliminarily, the protective effect of Bergenin was observed against H2O2-induced oxidative stress in HT-22 and PC-12 cells. Further studies were performed in 5xFAD Tg mouse model by administering Bergenin (1, 30 and 60 mg/kg; orally), whereas Bergenin (60 mg/kg) significantly attenuated the memory deficit observed in the Y-maze and Morris water maze (MWM) test. Fourier transform-infrared (FT-IR) spectroscopy displayed restoration of lipids, proteins and their derivatives compared to the 5xFAD Tg mice group. The differential scanning calorimeter (DSC) suggested an absence of amyloid beta (Aβ) aggregation in Bergenin-treated mice. The immunohistochemistry (IHC) analysis suggested the neuroprotective effect of Bergenin by increasing Reelin signaling (Reelin/Dab-1) and attenuated Aβ (1–42) aggregation in hippocampal regions of mouse brains. Furthermore, IHC and western blot results suggested antioxidant (Keap-1/Nrf-2/HO-1), anti-inflammatory (TLR-4/NF-kB) and anti-apoptotic (Bcl-2/Bax/Caspase-3) effect of Bergenin. Moreover, a decrease in Annexin V/PI-stained hippocampal cells suggested its effect against neurodegeneration. The histopathological changes were reversed significantly by Bergenin. In addition, a remarkable increase in antioxidant level with suppression of pro-inflammatory cytokines, oxidative stress and nitric oxide production were observed in specific regions of the mouse brains.

Dexmedetomidine Reverses Postoperative Spatial Memory Deficit by Targeting Surf1 and Cytochrome C

Neuroscience ◽  
2021 ◽  
Author(s):  
Kun Niu ◽  
Jia-Lin Qin ◽  
Guo-Fang Lu ◽  
Jian Guo ◽  
John P. Williams ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Spatial Memory ◽  
Memory Deficit ◽  
Spatial Memory Deficit

scholarly journals Positive Modulation of PinkNelumbo nuciferaFlowers on Memory Impairment, Brain Damage, and Biochemical Profiles in Restraint Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Thawatchai Prabsattroo ◽  
Jintanaporn Wattanathorn ◽  
Pichet Somsapt ◽  
Opass Sritragool
Keyword(s):  
Oxidative Stress ◽  
Monoamine Oxidase ◽  
Spatial Memory ◽  
Brain Damage ◽  
Memory Deficit ◽  
Ki67 Expression ◽  
Mao B ◽  
Serum Corticosterone ◽  
Neuron Density ◽  
Oxidative Stress Status

Due to the crucial role of oxidative stress in the stress-induced memory deficit, the benefit of substance possessing antioxidant effect is focused. Since no data are available, we aimed to determine the effect ofNelumbo nuciferaflowers extract on spatial memory and hippocampal damage in stressed rats. Male Wistar rats, weighing 250–350 g, were orally givenN. nuciferaextract at doses of 10, 10, and 200 mg·kg−145 minutes before the exposure to 12-hour restraint stress. The spatial memory and serum corticosterone were assessed at 7 and 14 days of study period. At the end of study, acetylcholinesterase (AChE), monoamine oxidase type A and monoamine oxidase type B (MAO-A and MAO-B), oxidative stress status, neuron density, and Ki67 expression in hippocampus were also assessed. The results showed thatN. nuciferaextract decreased memory deficit and brain damage, serum corticosterone, oxidative stress status, AChE, and MAO-A and MAO-B activities but increased neuron density and Ki67 expression in hippocampus. These suggested that the improved oxidative stress status, adult neurogenesis, and cholinergic and monoaminergic functions might be responsible for the protective effect against stress-related brain damage and dysfunction of the extract. Therefore,N. nuciferaextract is the potential neuroprotective and memory enhancing agent. However, further researches are still required.

scholarly journals Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats

2019 ◽  
Vol 129 (5) ◽  
pp. 1365-1373 ◽  
Author(s):  
Gregory A. Chinn ◽  
Jennifer M. Sasaki Russell ◽  
Esther T. Banh ◽  
Saehee C. Lee ◽  
Jeffrey W. Sall
Keyword(s):  
Spatial Memory ◽  
Early Life ◽  
Memory Deficit ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Spatial Memory Deficit
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