Helium preconditioning protects the brain against hypoxia/ischemia injury via improving the neurovascular niche in a neonatal rat model

2016 ◽  
Vol 314 ◽  
pp. 165-172 ◽  
Author(s):  
Yi Li ◽  
Peixi Zhang ◽  
Ying Liu ◽  
Wenwu Liu ◽  
Na Yin
Keyword(s):  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neurovascular Niche ◽  
The Brain ◽  
Neonatal Rat Model

scholarly journals PO-274 Photobiomodulation Preconditioning Prevents Hypoxia-ischemia Induced Dyscinesia in a Neonatal Rat Model

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Luodan Yang ◽  
Chongyun Wu ◽  
Guangcong Peng ◽  
Mengyun Xiao ◽  
Quanguang Zhang
Keyword(s):  
Cytochrome C ◽  
Rat Model ◽  
Neuronal Apoptosis ◽  
Mitochondrial Dynamics ◽  
Neonatal Rat ◽  
Mitochondrial Fragmentation ◽  
Cytochrome C Release ◽  
Hypoxia Ischemia ◽  
The Brain ◽  
Neonatal Rat Model

Objective Neonatal hypoxia-ischemia (HI) injury caused by oxygen deprivation is the most common cause of severe neurologic deficits and dyscinesia in neonates. The work was designed to evaluate the preventative effect of photobiomodulation (PBM) preconditioning on HI-induced Dyscinesia in a Neonatal Rat Model, and its underlying mechanism of PBM action on brain damage in a HI model in neonatal rats. Methods 10-day-old neonatal Sprague-Dawley rats were randomly divided into 3 groups: (a) control group (animals without ligation); (b) HI group (HI animal with PBM pretreatment); (c) PBM group (HI animal with PBM pretreatment). The hanging wire test and cylinder test were conducted to evaluate the the strength and asymmetry of left (contralateral) paw usage, respectively. The volume shrinkage of the brain was analyzed on postnatal day 29. The neuronal loss, mitochondrial dynamics, mitochondrial fragmentation, cytochrome c release, neuronal apoptosis, dendritic and synaptic injury in hippocampus were tested using the brain collected on postnatal day 16. Results PBM preconditioning significantly attenuated motor function impairment, volume shrinkage, neuron loss, dendritic and synaptic injury after HI. Further mechanistic investigation showed that PBM preconditioning effectively restore HI-induced mitochondrial dynamic changes and inhibit mitochondrial fragmentation, accompanied by a robust suppression of cytochrome c release, and prevention of neuronal apoptosis by inhibition of caspase activation. Conclusions PBM preconditioning can prevent HI induced dyscinesia and brain injury by maintaining mitochondrial dynamics and inhibiting mitochondrial apoptotic pathway.  

ISDN2014_0189: Sulforaphane is not additive in combination with hypothermia in a neonatal rat model of hypoxia–ischemia

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 55-55 ◽  
Author(s):  
Ann‐Marie Przyslupski ◽  
Edward Armstrong ◽  
Keqin Shen ◽  
Jerome Y. Yager
Keyword(s):  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

Cerebral blood flow in a neonatal rat model of hypoxia-ischemia

2014 ◽  
Author(s):  
Erin M. Buckley ◽  
Shyama Patel ◽  
Benjamin Miller ◽  
P. Ellen Grant ◽  
Maria Angela Franceschini ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

Carnosine pretreatment protects against hypoxia–ischemia brain damage in the neonatal rat model

2011 ◽  
Vol 667 (1-3) ◽  
pp. 202-207 ◽  
Author(s):  
Xiangmin Zhang ◽  
Lili Song ◽  
Xiuyong Cheng ◽  
Yi Yang ◽  
Bin Luan ◽  
...  
Keyword(s):  
Brain Damage ◽  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

scholarly journals Corrigendum: Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia‐ischemia

2020 ◽  
Vol 13 (9) ◽  
Author(s):  
Luodan Yang ◽  
Yan Dong ◽  
Chongyun Wu ◽  
Yong Li ◽  
Yichen Guo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model

2014 ◽  
Vol 727 ◽  
pp. 174-180 ◽  
Author(s):  
Huizhen Zhang ◽  
Shang Guo ◽  
Linlin Zhang ◽  
Liting Jia ◽  
Zhan Zhang ◽  
...  
Keyword(s):  
Brain Damage ◽  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

scholarly journals Establishment of a hypoxia ischemia reperfusion brain damage model in neonatal rats

2022 ◽  
Author(s):  
xiaoqin fu ◽  
tianlei zhang ◽  
wei lin ◽  
mengdie jiao ◽  
zhiwei zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Brain Tissue ◽  
Brain Damage ◽  
Rat Model ◽  
Ischemia Reperfusion ◽  
Neonatal Rat ◽  
Bridge Method ◽  
Hypoxia Ischemia ◽  
Group A ◽  
Neonatal Rat Model

Objective: Rice-Vannucci model has been widely used as HIE（Hypoxic ischemic encephalopathy ） animal model in the past forty years, but it does not mimic reperfusion injury that occurs during HIE. The aim of the present study was to establish a new neonatal rat model by simulating hypoxia ischemia reperfusion brain damage (HIRBD) through "common carotid artery (CCA) muscle bridge". Methods: Sixty 7-day-old male Sprague-Dawley rats were randomly assigned to group A (HIRBD groups, n=36), group B (Rice-Vannucci group, n=12), and group C (sham-operated group, n=12). Rats in group A were assigned to 3 subgroups (A1-A3, 12 animals/subgroup). Dynamic changes in cerebral blood flow (CBF) were evaluated by the laser speckle imaging system. The status of the CCA was observed under a stereomicroscope. Changes in body weight, gross morphology as well as pathological sections of brain tissue were examined to evaluate the feasibility of the model. Results: The results indicated that CCA muscle bridge successfully blocked the CBF. CBF was restored after removal of the CCA muscle bridge in HIRBD groups. The CCA was in good condition after removing the muscle bridge, and blood supply was not affected. Changes in body weight, gross morphology and pathological sections of brain tissue indicated that ischemia reperfusion induced by the CCA muscle bridge method caused varying degrees of brain damage. Conclusion: CCA muscle bridge method is effective for establishing a reliable, stable, and reproducible neonatal rat model for study of HIRBD.

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