Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning

2016 ◽  
Vol 309 ◽  
pp. 1-8 ◽  
Author(s):  
Fen Xue ◽  
Jin-wen Huang ◽  
Pei-yan Ding ◽  
Hong-gang Zang ◽  
Zhi-jian Kou ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Hyperbaric Oxygen ◽  
Antioxidant Defense ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effects ◽  
Hyperbaric Oxygen Preconditioning

scholarly journals Sirt1 Mediates Improvement in Cognitive Defects Induced by Focal Cerebral Ischemia Following Hyperbaric Oxygen Preconditioning in Rats

2017 ◽  
pp. 1029-1039 ◽  
Author(s):  
P. DING ◽  
D. REN ◽  
S. HE ◽  
M. HE ◽  
G. ZHANG ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Hyperbaric Oxygen ◽  
Cognitive Deficits ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Artery Occlusion ◽  
Beneficial Effects ◽  
Mechanistic Basis ◽  
Hyperbaric Oxygen Preconditioning

Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days after reperfusion and after short interfering RNA-mediated knockdown of sirtuin1 (Sirt1). HBO-PC increased pNF-H and DCX expression and mitigated cognitive deficits in MCAO rats. However, these effects were abolished by Sirt1 knockdown. Our results suggest that HBO-PC can protect the brain from injury caused by ischemia-reperfusion and that Sirt1 is a potential molecular target for therapeutic approaches designed to minimize cognitive deficits caused by cerebral ischemia.

scholarly journals Cyclooxygenase-2 Mediates Hyperbaric Oxygen Preconditioning in the Rat Model of Transient Global Cerebral Ischemia

Stroke ◽  
2011 ◽  
Vol 42 (2) ◽  
pp. 484-490 ◽  
Author(s):  
Oumei Cheng ◽  
Robert P. Ostrowski ◽  
Bihua Wu ◽  
Wenwu Liu ◽  
Chunhua Chen ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Hyperbaric Oxygen ◽  
Rat Model ◽  
Cyclooxygenase 2 ◽  
Global Cerebral Ischemia ◽  
Transient Global Cerebral Ischemia ◽  
Hyperbaric Oxygen Preconditioning
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