Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life

2016 ◽  
Vol 303 ◽  
pp. 76-84 ◽  
Author(s):  
Ana Paula Ardais ◽  
Andréia S. Rocha ◽  
Maurício Felisberto Borges ◽  
Gabriela T. Fioreze ◽  
Cássia Sallaberry ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Memory Impairment ◽  
Caffeine Consumption ◽  
Caffeine Exposure

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

scholarly journals Expression pattern of Anosmin-1 during pre- and postnatal rat brain development

2008 ◽  
Vol 237 (9) ◽  
pp. 2518-2528 ◽  
Author(s):  
Diego Clemente ◽  
Pedro F. Esteban ◽  
Ignacio Del Valle ◽  
Ana Bribián ◽  
Nadia Soussi-Yanicostas ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Expression Pattern

scholarly journals Characterization of cortical neurons that transiently express TH during rat brain development

2006 ◽  
Vol 295 (1) ◽  
pp. 405
Author(s):  
Steve Asmus ◽  
Mark Ball ◽  
Angela Bohnen ◽  
Kevin Phelps ◽  
Cindy Hartley ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Cortical Neurons

L-Arginine administration during rat brain development facilitates spreading depression propagation: evidence for a dose- and nutrition-dependent effect

2009 ◽  
Vol 12 (2) ◽  
pp. 73-80 ◽  
Author(s):  
L.M.S.S. Maia ◽  
A. Amancio-dos-Santos ◽  
D. Duda-de-Oliveira ◽  
M.K.C. Angelim ◽  
P.C.P. Germano ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Spreading Depression ◽  
Dependent Effect

Complex patterns of [125I]ω-conotoxin GVIA binding site expression during postnatal rat brain development

1994 ◽  
Vol 78 (1) ◽  
pp. 131-136 ◽  
Author(s):  
F. Filloux ◽  
Aaron Schapper ◽  
Scott R. Naisbitt ◽  
Baldomero M. Olivera ◽  
J. Michael McIntosh
Keyword(s):  
Brain Development ◽  
Binding Site ◽  
Rat Brain ◽  
Complex Patterns

Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain

2011 ◽  
Vol 100 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Pradeep K. Kamat ◽  
Santoshkumar Tota ◽  
Rakesh Shukla ◽  
Shakir Ali ◽  
Abul Kalam Najmi ◽  
...  
Keyword(s):  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Rat Brain ◽  
Okadaic Acid ◽  
Memory Impairment ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

The Regulation of the Expression, Phosphorylation, and Protein Associations of pp125FAKduring Rat Brain Development

1996 ◽  
Vol 7 (5) ◽  
pp. 391-403 ◽  
Author(s):  
Norberto Serpente ◽  
Marie-Christine Birling ◽  
Jack Price
Keyword(s):  
Brain Development ◽  
Rat Brain

scholarly journals Regulation of three beta-tubulin mRNAs during rat brain development.

1985 ◽  
Vol 4 (13B) ◽  
pp. 3667-3673 ◽  
Author(s):  
I. Ginzburg ◽  
A. Teichman ◽  
H.J. Dodemont ◽  
L. Behar ◽  
U.Z. Littauer
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Beta Tubulin

scholarly journals Differential Effects of Caffeine on Motor and Cognitive Outcomes of Penetrating Ballistic-Like Brain Injury

2019 ◽  
Vol 184 (Supplement_1) ◽  
pp. 291-300
Author(s):  
Sarah S Sanjakdar ◽  
William J Flerlage ◽  
Hyun S Kang ◽  
Douglas A Napier ◽  
Jaqueline R Dougherty ◽  
...  
Keyword(s):  
Brain Injury ◽  
Morris Water Maze ◽  
Water Maze ◽  
Right Hemisphere ◽  
Cognitive Outcome ◽  
Post Injury ◽  
Caffeine Consumption ◽  
Morris Water Maze Task ◽  
Chronic Caffeine ◽  
Caffeine Exposure

Abstract This study assessed the effect of caffeine on neurobehavioral recovery in the WRAIR penetrating ballistic-like brain injury (PBBI) model. Unilateral frontal PBBI was produced in the right hemisphere of anesthetized rats at moderate (7%-PBBI) or severe (10%-PBBI) injury levels. Animals were randomly assigned to pretreatment groups: acute caffeine (25 mg/kg CAF gavage, 1 h prior to PBBI), or chronic caffeine (0.25 g/L CAF drinking water, 30 days prior to PBBI). Motor function was evaluated on the rotarod at fixed-speed increments of 10, 15, and 20 RPM. Cognitive performance was evaluated on the Morris water maze. Acute caffeine showed no significant treatment effect on motor or cognitive outcome. Acute caffeine exposure prior to 10%-PBBI resulted in a significantly higher thigmotaxic response compared to vehicle-PBBI groups, which may indicate caffeine exacerbates post-injury anxiety/attention decrements. Results of the chronic caffeine study revealed a significant improvement in motor outcome at 7 and 10 days post-injury in the 7%-PBBI group. However, chronic caffeine exposure significantly increased the latency to locate the platform in the Morris water maze task at all injury levels. Results indicate that chronic caffeine consumption prior to a penetrating TBI may provide moderate beneficial effects to motor recovery, but may worsen the neurocognitive outcome.

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