scholarly journals 6-Hydroxydopamine lesions of the anteromedial ventral striatum impair opposite-sex urinary odor preference in female mice

2014 ◽  
Vol 274 ◽  
pp. 243-247 ◽  
Author(s):  
Brett T. DiBenedictis ◽  
Adaeze O. Olugbemi ◽  
Michael J. Baum ◽  
James A. Cherry
Keyword(s):  
Ventral Striatum ◽  
Odor Preference ◽  
Female Mice ◽  
Opposite Sex ◽  
6 Hydroxydopamine

scholarly journals Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0255640
Author(s):  
Xin Zhao ◽  
Patryk Ziobro ◽  
Nicole M. Pranic ◽  
Samantha Chu ◽  
Samantha Rabinovich ◽  
...  
Keyword(s):  
Social Behavior ◽  
Social Interactions ◽  
Social Isolation ◽  
Social Behaviors ◽  
Social Motivation ◽  
Same Sex ◽  
Female Mice ◽  
The Social ◽  
Opposite Sex ◽  
Brain And Behavior

Humans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation. Mice are frequently used as a model to understand how social isolation impacts the brain and behavior. While the effects of chronic social isolation on mouse social behavior have been well studied, much less is known about how acute isolation impacts mouse social behavior and whether these effects vary according to the sex of the mouse and the behavioral context of the social encounter. To address these questions, we characterized the effects of acute (3-day) social isolation on the vocal and non-vocal social behaviors of male and female mice during same-sex and opposite-sex social interactions. Our experiments uncovered pronounced effects of acute isolation on social interactions between female mice, while revealing more subtle effects on the social behaviors of male mice during same-sex and opposite-sex interactions. Our findings advance the study of same-sex interactions between female mice as an attractive paradigm to investigate neural mechanisms through which acute isolation enhances social motivation and promotes social behavior.

scholarly journals Multimodal Learning of Pheromone Locations

2019 ◽  
Author(s):  
Meenakshi Pardasani ◽  
Shruti D. Marathe ◽  
Urvashi Dalvi ◽  
Nixon M. Abraham
Keyword(s):  
Mammalian Species ◽  
Vomeronasal Organ ◽  
Long Term Memory ◽  
Multimodal Learning ◽  
Reproductive Behaviors ◽  
Male Urine ◽  
Female Mice ◽  
Main Olfactory Epithelium ◽  
Opposite Sex

AbstractMemorizing pheromonal locations is critical for many mammalian species as it involves finding mates and avoiding competitors. In rodents, pheromonal sensing happens through both vomeronasal organ (VNO) and main olfactory epithelium (MOE). It remains unclear as to which modalities and cues are used by rodents to form these long-term memories efficiently. Here, we addressed this problem by training female mice on a multimodal task to locate pheromones by sampling volatiles emanating from male urine and associating with the dimensions of certain shapes sensed by their vibrissae. In this novel pheromone location assay, female mice’ preference towards male urine scent decayed over time while permitting them to explore pheromones versus neutral stimuli, water. On training the animals for associations involving olfactory and whisker systems, they were able to memorize the location of opposite sex pheromones, when tested 15 days later. This memory was not formed either when the somatosensory inputs through whisker pad were blocked or pheromonal cues were replaced by that of same sex. On investigating the neural correlates of volatile pheromone information processing, we observed increased neurogenesis in the main olfactory bulb (MOB) after two weeks of learning. However, the pheromonal exposure induced Whitten effect, the estrous cycle synchronization, did not cause any differences in the MOB mediated discrimination learning pace for various non-pheromonal volatiles. Our study thus provides the evidence for associations formed between different sensory modalities facilitating the long-term memory formation in social and reproductive behaviors.

scholarly journals Cross-hemispheric dopamine projections have functional significance

2016 ◽  
Vol 113 (25) ◽  
pp. 6985-6990 ◽  
Author(s):  
Megan E. Fox ◽  
Maria A. Mikhailova ◽  
Caroline E. Bass ◽  
Pavel Takmakov ◽  
Raul R. Gainetdinov ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Ventral Striatum ◽  
Dopamine Neurons ◽  
Dopamine System ◽  
Anesthetized Rats ◽  
Freely Moving ◽  
Midbrain Dopamine ◽  
Dopamine Signaling ◽  
6 Hydroxydopamine ◽  
Stimulation Of

Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson’s disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine–lesioned rats. These experiments are the first, to our knowledge, to show cross-hemispheric synchronicity in dopamine signaling and support a functional role for contralateral projections. In addition, our data reveal that psychostimulants, such as amphetamine, promote the coupling of dopamine transients between hemispheres.

scholarly journals DREADD-Induced Silencing of the Medial Olfactory Tubercle Disrupts the Preference of Female Mice for Opposite-Sex Chemosignals

eNeuro ◽  
2015 ◽  
Vol 2 (5) ◽  
pp. ENEURO.0078-15.2015 ◽  
Author(s):  
Brett T. DiBenedictis ◽  
Adaeze O. Olugbemi ◽  
Michael J. Baum ◽  
James A. Cherry
Keyword(s):  
Olfactory Tubercle ◽  
Female Mice ◽  
Opposite Sex

scholarly journals Disruption of urinary odor preference and lordosis behavior in female mice given lesions of the medial amygdala

2012 ◽  
Vol 105 (2) ◽  
pp. 554-559 ◽  
Author(s):  
Brett T. DiBenedictis ◽  
Kaitlin L. Ingraham ◽  
Michael J. Baum ◽  
James A. Cherry
Keyword(s):  
Medial Amygdala ◽  
Odor Preference ◽  
Female Mice
Sign in / Sign up

Export Citation Format

Share Document