Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study

2013 ◽  
Vol 238 ◽  
pp. 188-192 ◽  
Author(s):  
Shilpi Modi ◽  
Richa Trivedi ◽  
Kavita Singh ◽  
Pawan Kumar ◽  
Ram K.S. Rathore ◽  
...  
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Trait Anxiety ◽  
Preliminary Evidence ◽  
White Matter Tract ◽  
Uncinate Fasciculus

scholarly journals Microstructural Integrity of White Matter Moderates an Association Between Childhood Adversity and Adult Trait Anger

2018 ◽  
Author(s):  
M. Justin Kim ◽  
Maxwell L. Elliott ◽  
Tracy C. d’Arbeloff ◽  
Annchen R. Knodt ◽  
Spenser R. Radtke ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Individual Differences ◽  
White Matter ◽  
Negative Emotion ◽  
Childhood Adversity ◽  
Trait Anger ◽  
Uncinate Fasciculus ◽  
Imaging Data ◽  
Wide Range ◽  
Microstructural Integrity

AbstractAmongst a number of negative life sequelae associated with childhood adversity is the later expression of a higher dispositional tendency to experience anger and frustration to a wide range of situations (i.e., trait anger). We recently reported that an association between childhood adversity and trait anger is moderated by individual differences in both threat-related amygdala activity and executive control-related dorsolateral prefrontal cortex (dlPFC) activity, wherein individuals with relatively low amygdala and high dlPFC activity do not express higher trait anger even when having experienced childhood adversity. Here, we examine possible structural correlates of this functional dynamic using diffusion magnetic resonance imaging data from 647 young adult men and women volunteers. Specifically, we tested whether the degree of white matter microstructural integrity as indexed by fractional anisotropy modulated the association between childhood adversity and trait anger. Our analyses revealed that higher microstructural integrity of multiple pathways was associated with an attenuated link between childhood adversity and adult trait anger. Amongst these pathways was the uncinate fasciculus, which not only provides a major anatomical link between the amygdala and prefrontal cortex but also is associated with individual differences in regulating negative emotion through top-down cognitive reappraisal. These findings suggest that higher microstructural integrity of distributed white matter pathways including but not limited to the uncinate fasciculus may represent an anatomical foundation serving to buffer against the expression of childhood adversity as later trait anger, which is itself associated with multiple negative health outcomes.

scholarly journals Population-Based Tract-To-Region Connectome of the Human Brain and Its Hierarchical Topology

2021 ◽  
Author(s):  
Fang-Cheng Yeh
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Population Based ◽  
Cortical Region ◽  
White Matter Tract ◽  
Hierarchical Topology ◽  
Information Gap ◽  
Cortical Regions ◽  
Hierarchical Relation ◽  
Population Probability

Abstract Connectome maps region-to-region connectivities but does not inform which white matter pathways form the connections. Here we constructed the first population-based tract-to-region connectome to fill this information gap. The constructed connectome quantifies the population probability of a white matter tract innervating a cortical region. The results show that ~85% of the tract-to-region connectome entries are consistent across individuals, whereas the remaining (~15%) have substantial individual differences requiring individualized mapping. Further hierarchical clustering on cortical regions revealed their parcellations into dorsal, ventral, and limbic networks based on the tract-to-region connective patterns. The clustering results on white matter bundles revealed the connectome-based categorization of fiber bundle systems in the association pathways. This new tract-to-region connectome provides insights into the connective topology between cortical regions and white matter bundles. The derived hierarchical relation further offers a connectome-based categorization of gray matter and white matter structures.

scholarly journals Preliminary Evidence for White Matter Tract Abnormalities in Young Adults Exposed to Parental Verbal Abuse

2009 ◽  
Vol 65 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Jeewook Choi ◽  
Bumseok Jeong ◽  
Michael L. Rohan ◽  
Ann M. Polcari ◽  
Martin H. Teicher
Keyword(s):  
Young Adults ◽  
White Matter ◽  
Preliminary Evidence ◽  
Verbal Abuse ◽  
White Matter Tract

scholarly journals Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder

2009 ◽  
Vol 66 (7) ◽  
pp. 691-694 ◽  
Author(s):  
K. Luan Phan ◽  
Anton Orlichenko ◽  
Erin Boyd ◽  
Mike Angstadt ◽  
Emil F. Coccaro ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
White Matter ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Preliminary Evidence ◽  
Uncinate Fasciculus ◽  
White Matter Abnormality

White matter tract alterations in fragile X syndrome: Preliminary evidence from diffusion tensor imaging

2003 ◽  
Vol 118B (1) ◽  
pp. 81-88 ◽  
Author(s):  
Naama Barnea-Goraly ◽  
Stephan Eliez ◽  
Maj Hedeus ◽  
Vinod Menon ◽  
Christopher D. White ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Fragile X Syndrome ◽  
Diffusion Tensor ◽  
Fragile X ◽  
Preliminary Evidence ◽  
White Matter Tract

scholarly journals White-matter tract integrity in late-life depression: associations with severity and cognition

2013 ◽  
Vol 44 (7) ◽  
pp. 1427-1437 ◽  
Author(s):  
R. A. Charlton ◽  
M. Lamar ◽  
A. Zhang ◽  
S. Yang ◽  
O. Ajilore ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Learning And Memory ◽  
Late Life ◽  
White Matter Integrity ◽  
White Matter Tract ◽  
Uncinate Fasciculus ◽  
Depression Severity ◽  
Late Life Depression ◽  
White Matter Tracts

BackgroundAlthough significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC).MethodParticipants aged ⩾60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments.ResultsWhite-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p⩽0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ⩽0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p = 0.03); this tract also correlated with executive function (p = 0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ⩽0.05).ConclusionsWhite-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.

scholarly journals Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline

2020 ◽  
Author(s):  
Derek B. Archer ◽  
Elizabeth E. Moore ◽  
Niranjana Shashikumar ◽  
Logan Dumitrescu ◽  
Kimberly R. Pechman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
White Matter ◽  
Cognitive Decline ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Hippocampal Volume ◽  
White Matter Tract ◽  
Uncinate Fasciculus ◽  
Inferior Longitudinal Fasciculus

AbstractObjectiveHippocampal volume is a sensitive marker of neurodegeneration and a well-established predictor of age-related cognitive impairment. Recently, free-water (FW) magnetic resonance imaging (MRI) has shown associations with pathology in Alzheimer’s disease (AD), but it is still unclear whether these metrics are associated with measures of cognitive impairment. Here, we investigate whether FW and FW-corrected fractional anisotropy (FAT) within medial temporal lobe white matter tracts (cingulum, fornix, uncinate fasciculus, inferior longitudinal fasciculus, and tapetum) provides meaningful contribution to cognition and cognitive decline beyond hippocampal volume.Participants and MethodsVanderbilt Memory & Aging Project participants (n=319, 73±7 years, 59% male) with normal cognition and mild cognitive impairment (40% of cohort) underwent baseline brain MRI, including structural MRI to quantify hippocampal volume, diffusion MRI to quantify medial temporal lobe white matter tract FW and FAT, and longitudinal neuropsychological assessment with a mean follow-up of 3.5 years. Linear regressions were conducted to determine how hippocampal volume and white matter tract FW and FAT interact with baseline memory and executive function performances. Competitive model analyses determined the unique variance provided by white matter tract FW and FAT beyond that of hippocampal volume and other comorbidities. Linear mixed-effects models were conducted to determine how baseline hippocampal volume and white matter tract FW and FAT interact to explain longitudinal change in memory and executive function performances.ResultsFW in the inferior longitudinal fasciculus, tapetum, uncinate fasciculus, and cingulum were robustly associated with baseline memory and executive function. Further, competitive model analysis showed that tract FW contributed unique variance beyond other comorbidities and hippocampal volume for memory (ΔRadj2 range: 0.82-2.00%) and executive function (ΔRadj2 range: 0.88-1.87%). Longitudinal analyses demonstrated significant interactions of hippocampal volume and FAT in the inferior longitudinal fasciculus (p=0.02), tapetum (p=0.02), uncinate fasciculus (p=0.02), and cingulum (p=0.002) with decline in memory. For decline in executive function, we found significant interactions of hippocampal volume and FAT in inferior longitudinal fasciculus (p=0.03), tapetum (p=0.02), uncinate fasciculus (p=0.02), and fornix (p=0.02), as well as cingulum (p=0.02) and fornix (p=0.02) FW.ConclusionsOur results highlight novel associations between FW and FAT measures of medial temporal lobe tract microstructure and cognitive performance such that individuals with smaller hippocampal volumes and lower tract microstructure experience greater cognitive decline. These results suggest that white matter has a unique role in cognitive decline and, therefore, could be used to provide better disease staging, allowing for more precise disease monitoring in AD.

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