The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls—A randomized placebo-controlled, double-blind fMRI study

2013 ◽  
Vol 237 ◽  
pp. 300-307 ◽  
Author(s):  
Birgit Guse ◽  
Peter Falkai ◽  
Oliver Gruber ◽  
Heather Whalley ◽  
Lydia Gibson ◽  
...  
Keyword(s):  
Working Memory ◽  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Healthy Controls ◽  
Double Blind ◽  
Fmri Study

Naturalistic Study of the use of Transcranial Magnetic Stimulation in the Treatment of Depressive Relapse

2006 ◽  
Vol 40 (9) ◽  
pp. 764-768 ◽  
Author(s):  
Paul B. Fitzgerald ◽  
Jessica Benitez ◽  
Anthony R. De Castella ◽  
Timothy L. Brown ◽  
Z. Jeff Daskalakis ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Naturalistic Study ◽  
Treatment Of Depression ◽  
Long Term Impact ◽  
Over Time

Background: The efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression has been assessed in a number of acute treatment trials during the last 10 years. Little is known about the long-term impact of the treatment on the disorder and its effectiveness when applied for repeated relapses of depression over time. Method: Nineteen patients who had previously responded to rTMS in clinical trials received treatment with rTMS for a total of 30 episodes of depressive relapse. Results: Approximately 10 months elapsed between treatment episodes. The majority of patients achieved a significant improvement in each treatment course with significant improvements achieved in patients treated with both low-frequency right-sided rTMS and high-frequency left-sided rTMS. Conclusions: The study suggests that rTMS may have value in the treatment of episodes of depressive relapse with little reduction in efficacy over time.

Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine

Cephalalgia ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 464-472 ◽  
Author(s):  
Adriana B Conforto ◽  
Edson Amaro ◽  
André L Gonçalves ◽  
Juliane PP Mercante ◽  
Vera Z Guendler ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Transcranial Magnetic Stimulation ◽  
Chronic Migraine ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Sham Group ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Response ◽  
Double Blind ◽  
Proof Of Principle

Background High-frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex (rTMS-DLPFC) is an effective treatment for depression. Preliminary studies indicated beneficial effects of rTMS-DLPFC on pain relief in patients treated for depression, and in patients with chronic migraine. Methods In this randomized, double-blind, parallel-group, single-center, proof-of-principle clinical trial, we tested the hypothesis that 23 sessions of active rTMS-DLPFC delivered over eight weeks would be feasible, safe and superior to sham rTMS to decrease the number of headache days in 18 patients with chronic migraine without severe depression. Per-protocol analysis was performed. Results rTMS-DLPFC applied over eight weeks was feasible and safe in patients with chronic migraine. Contrary to our primary hypothesis, the number of headache days decreased significantly more in the sham group than in the group treated with active rTMS-DLPFC at eight weeks. Average decrease in headache days was >50% in the sham group, indicating a powerful placebo response. Pain intensity improved in both groups to a similar extent. Conclusions Positive results of M1 stimulation in other studies, and the absence of significant benefits of active high-frequency rTMS of the DLPFC in the present study, point to M1 as a more promising target than the DLPFC, for larger trials of noninvasive brain stimulation in patients with chronic migraine.

scholarly journals High Frequency Repetitive Transcranial Magnetic Stimulation Therapy For Chronic Neuropathic Pain: A Meta-analysis

2015 ◽  
Vol 6;18 (6;11) ◽  
pp. E1029-E1046 ◽  
Author(s):  
Qiwen Mu
Keyword(s):  
Neuropathic Pain ◽  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Analgesic Effect ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Meta Analysis ◽  
Optimal Parameters ◽  
Analgesic Effects

Background: Increasing evidence supports an analgesic effect of repetitive transcranial magnetic stimulation (rTMS) for neuropathic pain (NP). However, the optimal parameters of rTMS (stimulation frequency and treatment sessions) for achieving long-term analgesic effects remain unknown. This study analyzed the current findings in the literature. Objective: The aim of this study was to assess the optimal parameters of rTMS for NP, including the rTMS sessions needed for inducing acute as well as long-term analgesic effects. Study Design: A meta-analysis of the analgesic effect of high frequency rTMS (HF- rTMS) for neuropathic patients. Setting: This meta-analysis examined all studies involving the analgesic efficacy of HF-rTMS for NP. Methods: PubMed, Embase, and the Cochrane library were searched for clinical studies of rTMS treatment on NP published before December 31, 2014. Crude standardized mean differences (SMD) with 95% confidence interval (CI) were calculated for pain intensity after different treatment sessions (from 1 to 10) and follow-up of one or 2 months after rTMS treatment using random effect models. Results: Twenty-five studies (including 32 trials and 589 patients) were selected for the metaanalysis according to the inclusion and exclusion criteria. All 3 HF-rTMS treatments (5, 10, and 20 Hz) produced pain reduction, while there were no differences between them, with the maximal pain reduction found after one and 5 sessions of rTMS treatment. Further, this significant analgesic effect remained forone month after 5 sessions of rTMS treatment. Limitations: There are limitations of this meta-analysis. For example, the long-term analgesic effects of different HF-rTMS and low frequency (LF) rTMS sessions, including the single session of rTMS on different NP of varying origins have yet not been evaluated; the full degree of pain relief is still unclear for many rTMS studies. Conclusions: HF-rTMS stimulation on primary motor cortex is effective in relieving pain in NP patients. Although 5 sessions of rTMS treatment produced a maximal analgesic effect and may be maintained for at least one month, further large-scale and well-controlled trials are needed to determine if this enhanced effect is specific to certain types of NP such as post-stroke related central NP. Key words: High frequency, repetitive transcranial magnetic stimulation, neuropathic pain, single stimulation, multiple stimulation, meta-analysis

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