D1 receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats

2013 ◽  
Vol 238 ◽  
pp. 36-43 ◽  
Author(s):  
Masakuni Horiguchi ◽  
Kayleen E. Hannaway ◽  
Adesewa E. Adelekun ◽  
Mei Huang ◽  
Karu Jayathilake ◽  
...  
Keyword(s):  
Object Recognition ◽  
D1 Receptor ◽  
Female Rats ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Receptor Agonists

scholarly journals Prevention of the Phencyclidine-Induced Impairment in Novel Object Recognition in Female Rats by Co-Administration of Lurasidone or Tandospirone, a 5-HT1A Partial Agonist

2012 ◽  
Vol 37 (10) ◽  
pp. 2175-2183 ◽  
Author(s):  
Masakuni Horiguchi ◽  
Kayleen E Hannaway ◽  
Adesewa E Adelekun ◽  
Karu Jayathilake ◽  
Herbert Y Meltzer
Keyword(s):  
Object Recognition ◽  
Partial Agonist ◽  
Female Rats ◽  
Novel Object Recognition ◽  
Novel Object

scholarly journals A Sensitive Homecage-Based Novel Object Recognition Task for Rodents

2021 ◽  
Vol 15 ◽  
Author(s):  
Jessica I. Wooden ◽  
Michael J. Spinetta ◽  
Teresa Nguyen ◽  
Charles I. O’Leary ◽  
J. Leigh Leasure
Keyword(s):  
Object Recognition ◽  
Task Difficulty ◽  
Recognition Task ◽  
Test Phase ◽  
Female Rats ◽  
Cognitive Test ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Novel Objects ◽  
Rats And Mice

The recognition of novel objects is a common cognitive test for rodents, but current paradigms have limitations, such as low sensitivity, possible odor confounds and stress due to being performed outside of the homecage. We have developed a paradigm that takes place in the homecage and utilizes four stimuli per trial, to increase sensitivity. Odor confounds are eliminated because stimuli consist of inexpensive, machined wooden beads purchased in bulk, so each experimental animal has its own set of stimuli. This paradigm consists of three steps. In Step 1, the sampling phase, animals freely explore familiar objects (FO). Novel Objects (NO1 and NO2) are soiled with bedding from the homecage, to acquire odor cues identical to those of the FO. Steps 2 and 3 are test phases. Herein we report results of this paradigm from neurologically intact adult rats and mice of both sexes. Identical procedures were used for both species, except that the stimuli used for the mice were smaller. As expected in Step 2 (NO1 test phase), male and female rats and mice explored NO1 significantly more than FO. In Step 3 (NO2 test phase), rats of both sexes demonstrated a preference for NO2, while this was seen only in female mice. These results indicate robust novelty recognition during Steps 2 and 3 in rats. In mice, this was reliably seen only in Step 2, indicating that Step 3 was difficult for them under the given parameters. This paradigm provides flexibility in that length of the sampling phase, and the delay between test and sampling phases can be adjusted, to tailor task difficulty to the model being tested. In sum, this novel object recognition test is simple to perform, requires no expensive supplies or equipment, is conducted in the homecage (reducing stress), eliminates odor confounds, utilizes 4 stimuli to increase sensitivity, can be performed in both rats and mice, and is highly flexible, as sampling phase and the delay between steps can be adjusted to tailor task difficulty. Collectively, these results indicate that this paradigm can be used to quantify novel object recognition across sex and species.

scholarly journals Adolescent Alcohol Exposure Produces Protracted Cognitive-Behavioral Impairments in Adult Male and Female Rats

2020 ◽  
Vol 10 (11) ◽  
pp. 785
Author(s):  
Victoria Macht ◽  
Natalie Elchert ◽  
Fulton Crews
Keyword(s):  
Working Memory ◽  
Object Recognition ◽  
Problem Solving ◽  
Binge Drinking ◽  
Memory Task ◽  
Alcohol Exposure ◽  
Cognitive Behavioral ◽  
Female Rats ◽  
Novel Object Recognition ◽  
Novel Object

Binge drinking is common in adolescence. Rodent studies modeling adolescent binge drinking find persistent effects on the brain’s physiology, including increased expression of neuroimmune genes, impaired neurogenesis, and changes in behavioral flexibility. This study used females and males to investigate the effects of adolescent intermittent ethanol (AIE) on a battery of behaviors assessing spatial navigation using a radial arm water maze, working memory using the Hebb-Williams maze, non-spatial long-term memory using novel object recognition, and dominance using a tube dominance test. Results indicate that AIE impairs adult acquisition in spatial navigational learning with deficits predominantly driven by females. Surprisingly, AIE slowed the transition from random to serial search strategies in both sexes, suggesting AIE impairs flexibility in problem-solving processing. In the Hebb-Williams maze working memory task, adult AIE rats exhibited deficits in problem solving, resulting in more errors across the 12 maze configurations, independent of sex. Conversely, AIE decreased dominance behaviors in female rats, and at 7 months post-alcohol, female AIE rats continued to exhibit deficits in novel object recognition. These results suggest that cognitive-behavioral alterations after adolescent binge drinking persist well into middle age, despite abstinence. Future studies should focus on intervening treatment strategies in both females and males.

scholarly journals Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats

2018 ◽  
Vol 55 (8) ◽  
pp. 6984-6999 ◽  
Author(s):  
Gemma Sangüesa ◽  
Mar Cascales ◽  
Christian Griñán ◽  
Rosa María Sánchez ◽  
Núria Roglans ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Insulin Signaling ◽  
Female Rats ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Brain Insulin ◽  
Object Recognition Memory

Impairment of novel object recognition learning and brain insulin signaling in fructose-, but not glucose-drinking, female rats

2017 ◽  
Vol 263 ◽  
pp. e268
Author(s):  
Marta Alegret ◽  
Gemma Sangüesa ◽  
Mar Cascales ◽  
Christian Griñán ◽  
Rosa M Sánchez ◽  
...  
Keyword(s):  
Object Recognition ◽  
Insulin Signaling ◽  
Female Rats ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Brain Insulin ◽  
Recognition Learning
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