scholarly journals Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats

2012 ◽  
Vol 234 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Amanda J. Skwara ◽  
Tracy E. Karwoski ◽  
R. Kenneth Czambel ◽  
Robert T. Rubin ◽  
Michael E. Rhodes
Keyword(s):  
Single Dose ◽  
Environmental Enrichment ◽  
Nicotine Withdrawal ◽  
Female Rats ◽  
Male And Female ◽  
Hypothalamic Pituitary Adrenal ◽  
Male And Female Rats

Behavioral effects of nicotine withdrawal in adult male and female rats

2009 ◽  
Vol 92 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Kristen R. Hamilton ◽  
Sarah Shafer Berger ◽  
Michael E. Perry ◽  
Neil E. Grunberg
Keyword(s):  
Adult Male ◽  
Nicotine Withdrawal ◽  
Behavioral Effects ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Environmental enrichment attenuates nicotine behavioral sensitization in male and female rats.

2014 ◽  
Vol 22 (4) ◽  
pp. 356-363 ◽  
Author(s):  
Kristen R. Hamilton ◽  
Brenda M. Elliott ◽  
Sarah Shafer Berger ◽  
Neil E. Grunberg
Keyword(s):  
Environmental Enrichment ◽  
Behavioral Sensitization ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Differential Effects of Extended Exercise and Memantine Treatment on Adult Neurogenesis in Male and Female Rats

2018 ◽  
Author(s):  
Shaina P Cahill ◽  
John Darby Cole ◽  
Ru Qi Yu ◽  
Jack Clemans-Gibbon ◽  
Jason S Snyder
Keyword(s):  
Nmda Receptor ◽  
Cell Density ◽  
Adult Neurogenesis ◽  
Environmental Enrichment ◽  
Antidepressant Drugs ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Related ◽  
Males And Females

ABSTRACTThe creation of new neurons in adulthood has potential for treating a number of disorders that are characterized by neurodegeneration or impaired plasticity. Animal models of reduced neurogenesis, and studies of the volume and structural integrity of the hippocampus in humans, suggest a possible therapeutic role for adult neurogenesis in age-related cognitive decline, depression, and schizophrenia. Research over the past 20 years has identified a number of approaches for enhancing adult neurogenesis, such as exercise, NMDA receptor antagonists, antidepressant drugs and environmental enrichment. However, despite the chronic nature of many disorders that impact the human hippocampus, most animal studies have only examined the efficacy of neurogenic treatments over relatively short timescales (∼1 month or less). Additionally, investigations into the regulation of neurogenesis typically include only 1 sex, even though many disorders that affect the hippocampus differentially impact males and females. Here, we therefore tested whether two known pro-neurogenic treatments, running and the NMDA receptor antagonist, memantine, could lead to long-term increases in neurogenesis in male and female rats. We found that continuous access to a running wheel (cRUN) initially increased neurogenesis in both sexes, but effects were minimal after 1 month (both sexes) and completely absent after 5 months (males). Similarly, a single injection of memantine (sMEM) only transiently increased adult neurogenesis in both males and females. To determine whether extended increases in neurogenesis were possible with 2 months of RUN and MEM treatments, we subjected rats to interval running (iRUN), weekly memantine injections (mMEM), or combined treatments (iRUN-mMEM, mMEM-iRUN). We found that 2 months of iRUN increased DCX+ cell density in females but iRUN-mMEM treatment increased DCX+ cell density in males. However, analyses with thymidine analogs revealed that neurogenesis was minimally increased during the initial phases of the 2 month treatments. Collectively, our findings identify sex differences in the efficacy of neurogenic manipulations, which may be relevant for designing plasticity-promoting treatments that target the hippocampus.

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