Role of D1/D2 dopamine receptors in the CA1 region of the rat hippocampus in the rewarding effects of morphine administered into the ventral tegmental area

2012 ◽  
Vol 231 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Mohammad-Hossein Esmaeili ◽  
Mojtaba Kermani ◽  
Asghar Parvishan ◽  
Abbas Haghparast
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Receptors ◽  
Rat Hippocampus ◽  
D2 Dopamine Receptors ◽  
Ca1 Region ◽  
Ventral Tegmental

Role of D1-like and D2-like dopamine receptors within the ventral tegmental area in stress-induced and drug priming-induced reinstatement of morphine seeking in rats

2018 ◽  
Vol 29 (5) ◽  
pp. 426-436 ◽  
Author(s):  
Sharareh Farahimanesh ◽  
Marzieh Moradi ◽  
Farzaneh Nazari-Serenjeh ◽  
Shahram Zarrabian ◽  
Abbas Haghparast
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Receptors ◽  
Ventral Tegmental

Role of dopamine receptors in the ventral tegmental area in conditioned fear

2009 ◽  
Vol 199 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Amanda Ribeiro de Oliveira ◽  
Adriano Edgar Reimer ◽  
Marcus Lira Brandão
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Receptors ◽  
Conditioned Fear ◽  
Ventral Tegmental

Modulatory role of the orexin system in stress‐induced analgesia: Involvement of the ventral tegmental area

2021 ◽  
Author(s):  
Kobra Askari ◽  
Shahrbanoo Oryan ◽  
Akram Eidi ◽  
Jalal Zaringhalam ◽  
Abbas Haghparast
Keyword(s):  
Ventral Tegmental Area ◽  
Ventral Tegmental

scholarly journals The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons

2021 ◽  
Author(s):  
Hongsheng Wang ◽  
Wanpeng Cui ◽  
Wenbing Chen ◽  
Fang Liu ◽  
Zhaoqi Dong ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
Coping With Stress ◽  
Chemical Genetic ◽  
Chronic Social Defeat Stress ◽  
Ventral Tegmental ◽  
Laterodorsal Tegmentum ◽  
Specific Deletion

AbstractDopamine (DA) neurons in the ventral tegmental area (VTA) are critical to coping with stress. However, molecular mechanisms regulating their activity and stress-induced depression were not well understood. We found that the receptor tyrosine kinase ErbB4 in VTA was activated in stress-susceptible mice. Deleting ErbB4 in VTA or in DA neurons, or chemical genetic inhibition of ErbB4 kinase activity in VTA suppressed the development of chronic social defeat stress (CSDS)-induced depression-like behaviors. ErbB4 activation required the expression of NRG1 in the laterodorsal tegmentum (LDTg); LDTg-specific deletion of NRG1 inhibited depression-like behaviors. NRG1 and ErbB4 suppressed potassium currents of VTA DA neurons and increased their firing activity. Finally, we showed that acute inhibition of ErbB4 after stress attenuated DA neuron hyperactivity and expression of depression-like behaviors. Together, these observations demonstrate a critical role of NRG1-ErbB4 signaling in regulating depression-like behaviors and identify an unexpected mechanism by which the LDTg-VTA circuit regulates the activity of DA neurons.

scholarly journals Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area   Opioid Receptors

2015 ◽  
Vol 35 (35) ◽  
pp. 12217-12231 ◽  
Author(s):  
L. Hipolito ◽  
A. Wilson-Poe ◽  
Y. Campos-Jurado ◽  
E. Zhong ◽  
J. Gonzalez-Romero ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Opioid Receptors ◽  
Inflammatory Pain ◽  
Self Administration ◽  
Ventral Tegmental
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