Unilateral lesion of dorsal hippocampus in adult rats impairs contralateral long-term potentiation in vivo and spatial memory in the early postoperative phase

2012 ◽  
Vol 230 (2) ◽  
pp. 428-432 ◽  
Author(s):  
Hongjie Li ◽  
Xiaoyan Wu ◽  
Yanrui Bai ◽  
Yan Huang ◽  
Wenting He ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Dorsal Hippocampus ◽  
Long Term Potentiation ◽  
Postoperative Phase ◽  
Unilateral Lesion ◽  
Adult Rats ◽  
Term Potentiation

scholarly journals Effects of perfluorooctane sulfonate and its alternatives on long-term potentiation in the hippocampus CA1 region of adult rats in vivo

2016 ◽  
Vol 5 (2) ◽  
pp. 539-546 ◽  
Author(s):  
Qian Zhang ◽  
Wei Liu ◽  
Qiao Niu ◽  
Yu Wang ◽  
Huimin Zhao ◽  
...  
Keyword(s):  
Health Effects ◽  
Perfluorooctane Sulfonate ◽  
Long Term Potentiation ◽  
Adult Rats ◽  
Ca1 Region ◽  
Term Potentiation

With the limited but ongoing usage of perfluorooctane sulfonate (PFOS), the health effects of both PFOS and its alternatives are far from being understood.

scholarly journals Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood

2018 ◽  
Author(s):  
Milene Borsoi ◽  
Antonia Manduca ◽  
Anissa Bara ◽  
Olivier Lassalle ◽  
Anne-Laure Pelissier-Alicot ◽  
...  
Keyword(s):  
Sex Differences ◽  
Social Behavior ◽  
Pyramidal Neurons ◽  
Long Term Potentiation ◽  
Adult Males ◽  
Adult Rats ◽  
Term Potentiation ◽  
Cannabis Consumption

AbstractHeavy cannabis consumption among adolescents is associated with significant and lasting neurobiological, psychological and health consequences that depend on the age of first use. Chronic exposure to cannabinoid (CB) agonists during adolescence alters social behavior and prefrontal cortex (PFC) activity in adult rats. However, sex differences on social behavior as well as PFC synaptic plasticity after acute CB activation remain poorly explored. Here, we determined the consequences of a single CB activation differently affects PFC in males and females by assessing social behavior and PFC neuronal and synaptic functions in rats during pubertal or adulthood periods, 24h after a single in-vivo cannabinoid exposure (SCE). During puberty, SCE reduced play behavior in females but not males. In contrast, SCE impaired sociability in both sexes at adulthood. General exploration and memory recognition remained normal at both ages and both sexes. At the synaptic level, SCE ablated endocannabinoid-mediated long-term depression (eCB-LTD) in the PFC of females of both ages and heightened excitability of PFC pyramidal neurons at adulthood, while males were spared. In contrast, SCE was associated to impaired long-term potentiation in adult males. Together, the data indicate behavioral and synaptic sex differences in response to a single in-vivo exposure to cannabinoid at puberty and adulthood.

scholarly journals Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats

2018 ◽  
Vol 12 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Dongyong Guo ◽  
Jianhui Gan ◽  
Tao Tan ◽  
Xin Tian ◽  
Guolin Wang ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Long Term Potentiation ◽  
Neonatal Exposure ◽  
Adult Rats ◽  
Term Potentiation

scholarly journals Associative spike timing-dependent potentiation of the basal dendritic excitatory synapses in the hippocampus in vivo

2016 ◽  
Vol 115 (6) ◽  
pp. 3264-3274 ◽  
Author(s):  
Thomas K. Fung ◽  
Clayton S. Law ◽  
L. Stan Leung
Keyword(s):  
Current Source ◽  
Long Term Potentiation ◽  
Spike Timing ◽  
Stratum Radiatum ◽  
Adult Rats ◽  
Synaptic Excitation ◽  
Stratum Oriens ◽  
Term Potentiation

Spike timing-dependent plasticity in the hippocampus has rarely been studied in vivo. Using extracellular potential and current source density analysis in urethane-anesthetized adult rats, we studied synaptic plasticity at the basal dendritic excitatory synapse in CA1 after excitation-spike (ES) pairing; E was a weak basal dendritic excitation evoked by stratum oriens stimulation, and S was a population spike evoked by stratum radiatum apical dendritic excitation. We hypothesize that positive ES pairing—generating synaptic excitation before a spike—results in long-term potentiation (LTP) while negative ES pairing results in long-term depression (LTD). Pairing (50 pairs at 5 Hz) at ES intervals of −10 to 0 ms resulted in significant input-specific LTP of the basal dendritic excitatory sink, lasting 60–120 min. Pairing at +10- to +20-ms ES intervals, or unpaired 5-Hz stimulation, did not induce significant basal dendritic or apical dendritic LTP or LTD. No basal dendritic LTD was found after stimulation of stratum oriens with 200 pairs of high-intensity pulses at 25-ms interval. Pairing-induced LTP was abolished by pretreatment with an N-methyl-d-aspartate receptor antagonist, 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), which also reduced spike bursting during 5-Hz pairing. Pairing at 0.5 Hz did not induce spike bursts or basal dendritic LTP. In conclusion, ES pairing at 5 Hz resulted in input-specific basal dendritic LTP at ES intervals of −10 ms to 0 ms but no LTD at ES intervals of −20 to +20 ms. Associative LTP likely occurred because of theta-rhythmic coincidence of subthreshold excitation with a backpropagated spike burst, which are conditions that can occur naturally in the hippocampus.

scholarly journals Hippocampal Neuropeptide Y2 receptor blockade improves spatial memory retrieval and modulates limbic brain metabolism

2021 ◽  
Author(s):  
Marta Mendez-Couz ◽  
Hector Gonzalez-Pardo ◽  
Jorge L Arias ◽  
Nelida M Conejo
Keyword(s):  
Spatial Memory ◽  
Brain Metabolism ◽  
Drugs Of Abuse ◽  
Dorsal Hippocampus ◽  
Long Term Potentiation ◽  
Brain Regions ◽  
Memory Recall ◽  
Y2 Receptor ◽  
Term Potentiation

Introduction: The neuropeptide Y (NPY) is broadly distributed in the central nervous system (CNS), and it has been related to neuroprotective functions. NPY seems to be an important component to counteract brain damage and cognitive impairment mediated by drugs of abuse and neurodegenerative diseases, and both NPY and its Y2 receptor (Y2R) are highly expressed in the hippocampus, critical for learning and memory. We have recently demonstrated its influence on cognitive functions; however, the specific mechanism and involved brain regions where NPY modulates spatial memory by acting on Y2R remain unclear. Methods: Here, we examined the involvement of the hippocampal NPY Y2R in spatial memory and associated changes in brain metabolism by bilateral administration of the selective antagonist BIIE0246 into the rat dorsal hippocampus. To further evaluate the relationship between memory functions and neuronal activity, we analysed the regional expression of the mitochondrial enzyme cytochrome c oxidase (CCO) as an index of oxidative metabolic capacity in limbic and non-limbic brain regions. Results: The acute blockade of NPY Y2R significantly improved spatial memory recall in rats trained in the Morris water maze that matched metabolic activity changes in spatial memory processing regions. Specifically, CCO activity changes were found in the dentate gyrus of the dorsal hippocampus and CA1 subfield of the ventral hippocampus, the infralimbic region of the PFC and the mammillary bodies. Conclusions: These findings suggest that the NPY hippocampal system, through its Y2R receptor, influences spatial memory recall (retrieval) and exerts control over patterns of brain activation that are relevant for associative learning, probably mediated by Y2R modulation of long-term potentiation and long-term depression.

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