Repeated cycles of restricted food intake and binge feeding disrupt sensory-specific satiety in the rat

2012 ◽  
Vol 231 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Soyon Ahn ◽  
Anthony G. Phillips
Keyword(s):  
Food Intake ◽  
Restricted Food Intake

Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain

2021 ◽  
Author(s):  
Ying Liu ◽  
Yu-chen Xu ◽  
Yu-gui Cui ◽  
Shi-wen Jiang ◽  
Fei-yang Diao ◽  
...  
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Androgen Excess ◽  
Ovary Syndrome ◽  
Leptin Signaling ◽  
Leptin Sensitivity ◽  
Androgen Levels ◽  
Restricted Food Intake

Background Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder characterized by high androgen levels. The aim of this study was to evaluate the effects of hyperandrogenism on the hypothalamus, and subsequently on the food intake and obesity in females. Methods A dihydroxy testosterone (DHT)-induced rat model was established to recapitulate the hyperandrogenism features of PCOS patients. Body weight and food intake of the rats were recorded. The food intake of DHT-induced rats was restricted by pair feeding to exclude possible effects of weight gain on the hypothalamus. The expression levels of relevant proteins and mRNAs in the hypothalamus, primary hypothalamic neurons exposed to DHT were analyzed by Western blotting and RT-PCR respectively. The leptin levels in serum and cerebrospinal fluid (CSF) were measured, and leptin was injected via the intracerebroventricular (ICV) route to test the leptin sensitivity of hypothalamus. Results The excessive pre-puberty androgen levels in the DHT-induced rats markedly elevated food intake prior to weight gain. Consistent with this, the expression of NPY and Agouti-related peptide (Agrp) mRNAs were up-regulated, which occurred prior to obesity and even with restricted food intake. In addition, the hypothalamic sensitivity to insulin and leptin was also impaired in the DHT-induced rats before obesity and with restricted food intake. DHT significantly reduced the leptin levels in the CSF, and ICV injection of leptin inhibited the DHT-induced increase in food intake. Conclusions Androgen excess increased food intake in rats and promoted obesity by down-regulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the CSF.

scholarly journals The effect of restricted food intake and refeeding on the ovarian follicle population of the pre-puberal Wistar rat

1981 ◽  
Vol 21 (5A) ◽  
pp. 611-620 ◽  
Author(s):  
Sue LINTERN-MOORE ◽  
A. V. EVERITT ◽  
J. C. MARIANA ◽  
P. MAULÉON
Keyword(s):  
Food Intake ◽  
Ovarian Follicle ◽  
Wistar Rat ◽  
Restricted Food Intake

Restricted food intake limits brown adipose tissue hypertrophy in cold exposure

Life Sciences ◽  
1982 ◽  
Vol 30 (17) ◽  
pp. 1423-1426 ◽  
Author(s):  
T. Scott Johnson ◽  
Shawne Murray ◽  
James B. Young ◽  
Lewis Landsberg
Keyword(s):  
Adipose Tissue ◽  
Food Intake ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Brown Adipose ◽  
Restricted Food Intake

Ketonuria in Pregnancy--With Special Reference to Calorie-restricted Food Intake in Obese Diabetics

Diabetes ◽  
1980 ◽  
Vol 29 (3) ◽  
pp. 177-181 ◽  
Author(s):  
E. J. Coetzee ◽  
W. P. U. Jackson ◽  
P. A. Berman
Keyword(s):  
Food Intake ◽  
Special Reference ◽  
In Pregnancy ◽  
Restricted Food Intake

scholarly journals Effect of Exercise on Osteopenia Caused by Restricted Food Intake in Rats

2003 ◽  
Vol 56 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Li Man Sun ◽  
Hajime Tamaki ◽  
Yutaka Ohta ◽  
Naofumi Katsuyama ◽  
Isao Chinen
Keyword(s):  
Food Intake ◽  
Restricted Food Intake
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