WITHDRAWN: Anterior cingulate cortex substitutes for the impaired retrieval role of prelimbic cortex in trace eyeblink conditioning

2011 ◽  
Author(s):  
Guang-yan Wu ◽  
Zheng-li Fan ◽  
Xuan Li ◽  
Bing Wu ◽  
Rui Fan ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Eyeblink Conditioning ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Prelimbic Cortex ◽  
Trace Eyeblink Conditioning

Activity Profiles of Single Neurons in Caudal Anterior Cingulate Cortex During Trace Eyeblink Conditioning in the Rabbit

2003 ◽  
Vol 90 (2) ◽  
pp. 599-612 ◽  
Author(s):  
Aldis P. Weible ◽  
Craig Weiss ◽  
John F. Disterhoft
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neuronal Activity ◽  
Eyeblink Conditioning ◽  
Neuronal Response ◽  
Trace Conditioning ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Excitatory Response ◽  
Excitatory Responses ◽  
Trace Eyeblink Conditioning

Acquisition of trace eyeblink conditioning involves the association of a conditioned stimulus (CS) with an unconditioned stimulus (US) separated by a stimulus-free trace interval. This form of conditioning is dependent upon the hippocampus and the caudal anterior cingulate cortex (AC), in addition to brain stem and cerebellar circuitry. Hippocampal involvement in trace eyeblink conditioning has been studied extensively, but the involvement of caudal AC is less well understood. In the present study, we compared neuronal responses from rabbits given either paired (trace conditioning) or unpaired (pseudoconditioning) presentations of the CS and US. Presentation of the CS elicited significant increases in neuronal activity at the onset of both trace conditioning and pseudoconditioning. A robust CS-elicited neuronal response persisted throughout the first 2 days of trace conditioning, declining gradually across subsequent training sessions. In contrast, the magnitude of the CS-elicited excitatory response during pseudoconditioning began to decline within the first 10 trials. Neurons exhibiting excitatory responses to the CS during trace conditioning also exhibited excitatory responses to the US that were significantly greater in magnitude than US-elicited responses during pseudoconditioning. CS-elicited decreases in neuronal activity became more robust over the course of trace conditioning compared to pseudoconditioning. Reductions in activity during the CS interval consistently preceded excitation in both training groups, suggesting that the CS-elicited decreases in neuronal activity may serve to increase the signal-to-noise ratio of the excitatory response to the tone. Taken together, these data suggest that the caudal AC is involved early in trace eyeblink conditioning and that maintenance of the CS-elicited excitatory response may serve to signal the salience of the tone.

scholarly journals Role of the Anterior Cingulate Cortex in Translational Pain Research

2021 ◽  
Vol 37 (3) ◽  
pp. 405-422
Author(s):  
Xiao Xiao ◽  
Ming Ding ◽  
Yu-Qiu Zhang
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pain Research

scholarly journals Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making

2009 ◽  
Vol 29 (8) ◽  
pp. 1678-1691 ◽  
Author(s):  
Mark E. Walton ◽  
James Groves ◽  
Katie A. Jennings ◽  
Paula L. Croxson ◽  
Trevor Sharp ◽  
...  
Keyword(s):  
Decision Making ◽  
Nucleus Accumbens ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
6 Hydroxydopamine

scholarly journals Transcranial Ultrasound Stimulation in Anterior Cingulate Cortex Impairs Information Sampling and Learning in Loss Contexts

2021 ◽  
Author(s):  
Kianoush Banaie Boroujeni ◽  
Michelle K Sigona ◽  
Robert Louie Treuting ◽  
Manuel J Thomas ◽  
Charles F Caskey ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Behavioral Flexibility ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Transcranial Ultrasound ◽  
Neural Signals ◽  
Visual Objects ◽  
Ultrasound Stimulation ◽  
Information Sampling

Neural activity in anterior cingulate cortex and the anterior striatum predicts which visual objects are sampled and how likely objects are paired with positive or aversive outcomes. We causally tested whether these neural signals contribute to behavioral flexibility. Disrupting with transcranial ultrasound the ACC, but not striatum, prolonged information sampling when attentional demands were high, impaired flexible learning, and reduced the ability to avoid losses. These results support a role of the ACC in guiding attention and information sampling to overcome motivational conflict during adaptive behaviors.

A role of anterior cingulate cortex in the emergence of worker–parasite relationship

2021 ◽  
Vol 118 (48) ◽  
pp. e2111145118
Author(s):  
Soyoun Ahn ◽  
Yujeong Kang ◽  
Jong Won Lee ◽  
Se Jin Jeong ◽  
Yoo Jin Lee ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Anterior Cingulate Cortex ◽  
Messenger Rna ◽  
Social Dilemma ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Parasite Relationship ◽  
Group Members ◽  
Lever Pressing

We studied the brain mechanisms underlying action selection in a social dilemma setting in which individuals’ effortful gains are unfairly distributed among group members. A stable “worker–parasite” relationship developed when three individually operant-conditioned rats were placed together in a Skinner box equipped with response lever and food dispenser on opposite sides. Specifically, one rat, the “worker,” engaged in lever-pressing while the other two “parasitic” rats profited from the worker’s effort by crowding the feeder in anticipation of food. Anatomically, c-Fos expression in the anterior cingulate cortex (ACC) was significantly higher in worker rats than in parasite rats. Functionally, ACC inactivation suppressed the worker’s lever-press behavior drastically under social, but only mildly under individual, settings. Transcriptionally, GABAA receptor– and potassium channel–related messenger RNA expressions were reliably lower in the worker’s, relative to parasite’s, ACC. These findings indicate the requirement of ACC activation for the expression of exploitable, effortful behavior, which could be mediated by molecular pathways involving GABAA receptor/potassium channel proteins.

scholarly journals Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex

2018 ◽  
Vol 673 ◽  
pp. 142-149 ◽  
Author(s):  
Munir Gunes Kutlu ◽  
Marie-France Marin ◽  
Jessica M. Tumolo ◽  
Navneet Kaur ◽  
Michael B. VanElzakker ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Fear Conditioning ◽  
Potential Role ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Nicotine Exposure
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