Triadimefon supports conditioned cue preference

2011 ◽  
Vol 221 (1) ◽  
pp. 307-310 ◽  
Author(s):  
John M. Holden ◽  
Michael Fitzgerald ◽  
Gabriel Bussell ◽  
Vanessa Ehlers
Keyword(s):  
Conditioned Cue Preference

scholarly journals Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christopher P. King ◽  
Jordan A. Tripi ◽  
Alesa R. Hughson ◽  
Aidan P. Horvath ◽  
Alexander C. Lamparelli ◽  
...  
Keyword(s):  
Drug Use ◽  
Individual Variability ◽  
Large Individual ◽  
Incentive Salience ◽  
Food Cues ◽  
Self Administration ◽  
Heterogeneous Stock ◽  
Conditioned Approach ◽  
The Individual ◽  
Conditioned Cue Preference

AbstractSensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience to food cues, which, in turn, contributes to the maintenance of cocaine self-administration, and cue-induced relapse of drug-seeking. Whereas each of these traits has established links to drug use, the relatedness between the individual traits themselves has not been well characterized in preclinical models. To this end, the propensity to attribute incentive salience to a food cue was first assessed in two distinct cohorts of 2716 outbred heterogeneous stock rats (HS; formerly N:NIH). We then determined whether each cohort was associated with performance in one of two paradigms (cocaine conditioned cue preference and cocaine contextual conditioning). These measure the unconditioned locomotor effects of cocaine, as well as conditioned approach and the locomotor response to a cocaine-paired floor or context. There was large individual variability and sex differences among all traits, but they were largely independent of one another in both males and females. These findings suggest that these traits may contribute to drug-use via independent underlying neuropsychological processes.

scholarly journals Memory enhancement produced by post-training exposure to sucrose-conditioned cues

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 22 ◽  
Author(s):  
Matthew R Holahan ◽  
Norman M White
Keyword(s):  
Memory Consolidation ◽  
Sucrose Solution ◽  
Radial Arm Maze ◽  
Conditioned Stimuli ◽  
Memory Enhancement ◽  
Aversive Stimuli ◽  
Long Evans ◽  
Conditioned Cue Preference ◽  
First Time ◽  
Conditioned Cues

A number of aversive and appetitive unconditioned stimuli (such as shock and food) are known to produce memory enhancement when they occur during the post-training period. Post-training exposure to conditioned aversive stimuli has also been shown to enhance memory consolidation processes. The present study shows for the first time that post-training exposure to conditioned stimuli previously paired with consumption of a sucrose solution also enhances memory consolidation. Male Long Evans rats were trained on a one-session conditioned cue preference (CCP) task on a radial arm maze. Immediately or 2 hours after training, rats consumed a sucrose solution or were exposed to cues previously paired with consumption of sucrose or cues previously paired with water. Twenty-four hours later, the rats were tested for a CCP. Immediate, but not delayed, post-training consumption of sucrose enhanced memory for the CCP. Immediate, but not delayed, post-training exposure to cues previously paired with sucrose, but not with water, also enhanced CCP memory. The possibility that rewarding and aversive conditioned stimuli affect memory by a common physiological process is discussed.

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