d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

2008 ◽  
Vol 186 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Jun-ichi Karasawa ◽  
Kenji Hashimoto ◽  
Shigeyuki Chaki
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Cognitive Deficits ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Mk 801 ◽  
Glycine Transporter ◽  
Novel Object Recognition Test

scholarly journals NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test

2013 ◽  
Vol 701 (1-3) ◽  
pp. 27-32 ◽  
Author(s):  
Karolina J. Janczura ◽  
Rafal T. Olszewski ◽  
Tomasz Bzdega ◽  
Dean J. Bacich ◽  
Warren D. Heston ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Peptidase Inhibitors ◽  
Novel Object Recognition Test ◽  
Naag Peptidase

scholarly journals Social State Influences Memory in Novel Object Recognition Test Through Oxidative Stress Balance in Male Rats

2018 ◽  
Vol 8 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hamidreza Famitafreshi ◽  
Morteza Karimian
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Memory Performance ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test ◽  
Nitrite Nitrate

Objective:Social isolation is associated with adverse effects on brain functions. According to previous studies, the reduction of oxidative stress improves cognitive functions. Memory performance is dependent on hippocampus and prefrontal function. The aim of this study is to show that impairment of memory in object recognition test in isolation state is accompanied by deregulation of oxidative stress balance in related areas.Methods and Materials:In this study, 14 male Sprague-Dawley rats were randomly divided into two groups as follows: social and isolation. Socialization and isolation plus one week of acclimatization occurred for fourteen days. At the end of the study, after performing behavioral test, (novel object recognition test) rats were anesthetized and sacrificed. After preparation of tissues in controlled condition, oxidative stress status in hippocampus and prefrontal cortex for Malondialdehyde (MDA), glutathione and nitrite/nitrate was assessed.Results:MDA in the hippocampus and prefrontal cortex was higher in isolated rats compared to social rats. Glutathione and nitrite/nitrate in the hippocampus and prefrontal cortex were lower in isolated rats compared to social rats. Memory performance in novel object recognition test both in short term and long term was better in social rats.Conclusion:Memory performance in novel object recognition test is influenced by social and oxidative stress status. So improving memory is possible through socialization and improvement of antioxidant status.

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