Aggressive behavior and HPA axis hormones after social isolation in adult rats of two different genetic animal models for depression

2006 ◽  
Vol 175 (2) ◽  
pp. 408-414 ◽  
Author(s):  
O. Malkesman ◽  
R. Maayan ◽  
A. Weizman ◽  
A. Weller
Keyword(s):  
Animal Models ◽  
Aggressive Behavior ◽  
Social Isolation ◽  
Hpa Axis ◽  
Adult Rats

Maternal separation attenuates the effect of adolescent social isolation on HPA axis responsiveness in adult rats

2014 ◽  
Vol 24 (7) ◽  
pp. 1152-1161 ◽  
Author(s):  
F. Biggio ◽  
M.G. Pisu ◽  
A. Garau ◽  
G. Boero ◽  
V. Locci ◽  
...  
Keyword(s):  
Social Isolation ◽  
Hpa Axis ◽  
Maternal Separation ◽  
Adult Rats

scholarly journals Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice

2019 ◽  
Vol 42 (12) ◽  
pp. 2009-2015 ◽  
Author(s):  
Hikari Iba ◽  
Takuya Watanabe ◽  
Kanae Matsuzawa ◽  
Maki Saimiya ◽  
Masako Tanaka ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Social Isolation ◽  
Arginine Vasopressin

Serotonin Receptors and Animal Models of Aggressive Behavior

1995 ◽  
Vol 28 (S 2) ◽  
pp. 80-90 ◽  
Author(s):  
B. Olivier ◽  
J. Mos ◽  
R. van Oorschot ◽  
R. Hen
Keyword(s):  
Animal Models ◽  
Aggressive Behavior ◽  
Serotonin Receptors

Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency

Life Sciences ◽  
2008 ◽  
Vol 82 (17-18) ◽  
pp. 909-914 ◽  
Author(s):  
Atsushi Takeda ◽  
Haruna Tamano ◽  
Fumika Kan ◽  
Tomoyuki Hanajima ◽  
Kohei Yamada ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Social Isolation ◽  
Zinc Deficiency ◽  
Young Mice

Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats

2017 ◽  
Vol 333 ◽  
pp. 258-266 ◽  
Author(s):  
Lan Sun ◽  
Li Min ◽  
Hao Zhou ◽  
Man Li ◽  
Feng Shao ◽  
...  
Keyword(s):  
Social Isolation ◽  
Adult Rats

scholarly journals Role of hypothalamic-pituitary adrenal-axis, toll-like receptors, and macrophage polarization in pre-atherosclerotic changes induced by social isolation stress in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arvin Haj-Mirzaian ◽  
Kiana Ramezanzadeh ◽  
Siavash Shariatzadeh ◽  
Michael Tajik ◽  
Farima Khalafi ◽  
...  
Keyword(s):  
Social Isolation ◽  
Chronic Stress ◽  
Hpa Axis ◽  
Macrophage Polarization ◽  
Toll Like Receptors ◽  
Isolation Stress ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Atherosclerotic Changes ◽  
Pituitary Adrenal Axis

AbstractIt has been well documented that chronic stress can induce atherosclerotic changes, however, the underlying mechanisms is yet to be established. In this regard, this study aimed to elucidate the relation between hypothalamic-pituitary adrenal-axis (HPA-axis), toll-like receptors (TLRs), as well as M1/M2 macrophage ratio and pre-atherosclerotic changes in social isolation stress (SIS) in mice. We used small interfering RNA against the glucocorticoid receptor (GR) to evaluate the relation between HPA-axis and TLRs. C57BL/6J mice were subjected to SIS and RT-PCR, ELISA, flow cytometry, and immunohistochemistry were used to assess the relations between pre-atherosclerotic changes and TLRs, macrophage polarization, pro-inflammatory cytokines, and cell adhesion molecules in aortic tissue. We used TAK-242 (0.3 mg/kg, intraperitoneally), a selective antagonist of TLR4, as a possible prophylactic treatment for atherosclerotic changes induced by SIS. We observed that isolated animals had higher serum concentration of corticosterone and higher body weight in comparison to normal animals. In isolated animals, results of in vitro study showed that knocking-down of the GR in bone marrow–derived monocytes significantly decreased the expression of TLR4. In vivo study suggested higher expression of TLR4 on circulating monocytes and higher M1/M2 ratio in aortic samples. Pathological study showed a mild pre-atherosclerotic change in isolated animals. Finally, we observed that treating animals with TAK-242 could significantly inhibit the pre-atherosclerotic changes. SIS can possibly increase the risk of atherosclerosis through inducing abnormal HPA-axis activity and subsequently lead to TLR4 up-regulation, vascular inflammation, high M1/M2 ratio in intima. Thus, TLR4 inhibitors might be a novel treatment to decrease the risk of atherosclerosis induced by chronic stress.

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