Hippocampal partial kindling decreased hippocampal GABAB receptor efficacy and wet dog shakes in rats

2006 ◽  
Vol 173 (2) ◽  
pp. 274-281 ◽  
Author(s):  
L LEUNG ◽  
B SHEN
Keyword(s):  
Gabab Receptor ◽  
Wet Dog Shakes

GABAb receptor-mediated inhibition of cholinergic function in mouse ileum requires the GABAb1 subunit

2001 ◽  
Vol 120 (5) ◽  
pp. A198-A198
Author(s):  
G SANGER ◽  
M MUNONYARA ◽  
H PROSSER ◽  
M PANGALOS ◽  
A HUNTER ◽  
...  
Keyword(s):  
Gabab Receptor ◽  
Cholinergic Function ◽  
Mouse Ileum

scholarly journals Molecular mechanisms of metabotropic GABAB receptor function

2021 ◽  
Vol 7 (22) ◽  
pp. eabg3362
Author(s):  
Hamidreza Shaye ◽  
Benjamin Stauch ◽  
Cornelius Gati ◽  
Vadim Cherezov
Keyword(s):  
G Protein ◽  
Molecular Mechanisms ◽  
Gabab Receptor ◽  
Neurological Diseases ◽  
Activation Mechanism ◽  
Allosteric Modulators ◽  
Inhibitory Neurotransmitter ◽  
Therapeutic Drugs ◽  
G Protein Coupled ◽  
The Brain

Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act both pre- and postsynaptically by modulating the transmission of neuronal signals and are involved in a range of neurological diseases, from alcohol addiction to epilepsy. A series of recent cryo-EM studies revealed critical details of the activation mechanism of GABAB. Structures are now available for the receptor bound to ligands with different modes of action, including antagonists, agonists, and positive allosteric modulators, and captured in different conformational states from the inactive apo to the fully active state bound to a G protein. These discoveries provide comprehensive insights into the activation of the GABAB receptor, which not only broaden our understanding of its structure, pharmacology, and physiological effects but also will ultimately facilitate the discovery of new therapeutic drugs and neuromodulators.

scholarly journals Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Latif Rachdi ◽  
Alicia Maugein ◽  
Severine Pechberty ◽  
Mathieu Armanet ◽  
Juliette Hamroune ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Line ◽  
Gabab Receptor ◽  
Pancreatic Beta Cell ◽  
Beta Cell Line ◽  
Regulated Expression ◽  
And Function

scholarly journals Analysis of signal transduction pathways caused by GABAB receptor subtypes - heterologous expression with Xenopus oocytes

2000 ◽  
Vol 82 ◽  
pp. 136
Author(s):  
Yasuhito Uezono ◽  
Muneshige Kaibara ◽  
Hiroki Yokoo ◽  
Hideyuki Kobayashi ◽  
Toshihiko Yanagita ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Heterologous Expression ◽  
Xenopus Oocytes ◽  
Gabab Receptor ◽  
Signal Transduction Pathways ◽  
Receptor Subtypes

In vivo andin vitro ethanol exposure in prenatal rat brain: GABAB receptor modulation on dopamine D1 receptor and protein kinase A

Synapse ◽  
2008 ◽  
Vol 62 (7) ◽  
pp. 534-543 ◽  
Author(s):  
H.Y. Lee ◽  
N. Naha ◽  
S.P. Li ◽  
M.J. Jo ◽  
M.L. Naseer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Rat Brain ◽  
Gabab Receptor ◽  
Ethanol Exposure ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Modulation ◽  
Kinase A
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