Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat

2006 ◽  
Vol 173 (1) ◽  
pp. 112-115 ◽  
Author(s):  
N PITSIKAS ◽  
N SAKELLARIDIS
Keyword(s):  
Crocus Sativus ◽  
Memory Impairments ◽  
Crocus Sativus L

scholarly journals Crocins, the Bioactive Components of Crocus sativus L., Counteract the Disrupting Effects of Anesthetic Ketamine on Memory in Rats

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 528
Author(s):  
Nikolaos Pitsikas ◽  
Petros A. Tarantilis
Keyword(s):  
Recognition Memory ◽  
Memory Deficits ◽  
Nmda Receptor Antagonist ◽  
Crocus Sativus ◽  
Bioactive Components ◽  
Memory Impairments ◽  
Bioactive Ingredients ◽  
Behavioral Memory ◽  
Spatial Recognition ◽  
Crocus Sativus L

Consistent experimental evidence suggests that anesthetic doses of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine cause severe memory impairments in rodents. Crocins are among the various bioactive ingredients of the plant Crocus sativus L., and their implication in memory is well-documented. It has not yet been elucidated if crocins are able to attenuate the memory deficits produced by anesthetic ketamine. The present study was undertaken aiming to clarify this issue in the rat. For this aim, the object recognition, the object location and the habituation tests, reflecting non-spatial recognition memory, spatial recognition memory and associative memory, respectively, were utilized. A post-training challenge with crocins (15–30 mg/kg, intraperitoneally (i.p.), acutely) counteracted anesthetic ketamine (100 mg/kg, i.p.)-induced performance impairments in all the above-mentioned behavioral memory paradigms. The current findings suggest that crocins modulate anesthetic ketamine’s amnestic effects.

Dermoprotective effects of saffron: A mini review

2021 ◽  
Vol 27 ◽  
Author(s):  
Hamid Rigi ◽  
Leila Mohtashami ◽  
Maryam Asnaashari ◽  
Zahra Tayarani-Najaran
Keyword(s):  
Skin Diseases ◽  
Food Additive ◽  
Crocus Sativus ◽  
Chemical Components ◽  
Protective Effects ◽  
Memory Impairments ◽  
Anti Oxidant ◽  
Crocus Sativus L

: Crocus sativus L. (Iridaceae), known as saffron, is widely used as a coloring agent, food additive, and medicinal spice. Saffron can be beneficial for treating convulsions, tumors, oxidative-related diseases, inflammation, memory impairments, and depression. These effects are due to its chemical components like anthocyanins, flavonoids and terpenoids. Saffron has been shown to be of benefit for treating skin diseases as a result of its anti-oxidant, anti-microbial, depigmenting, and repairing activities. Therefore, it is used for formulating various lotions, creams, and cosmetics emulsions, namely sunscreens, moisturizers, and anti-spot and anti-aging products. In this review, we have presented various skin protective effects of saffron and its components.

Neuentwicklung einer HPLC-Methode zur Qualitätskontrolle von Safran (Crocus sativus L.)

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
K Kuchta ◽  
HH Jin ◽  
RW Wang ◽  
HH He ◽  
L Fang ◽  
...  
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Biotechnological Studies in Saffron (Crocus sativus L.) Plant

2017 ◽  
Vol 7 (2) ◽  
pp. 343-352
Author(s):  
YONCA SURGUN ACAR ◽  
RABİA İŞKİL ◽  
BETÜL BÜRÜN
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Anti-toxicant Properties of Saffron and Relevance to Protection from Toxins and Drugs

2020 ◽  
Vol 16 (3) ◽  
pp. 265-283
Author(s):  
Kyriaki Hatziagapiou ◽  
George I. Lambrou
Keyword(s):  
Redox Reactions ◽  
Case Reports ◽  
Meta Analysis ◽  
Reactive Oxygen ◽  
Crocus Sativus ◽  
Protective Effects ◽  
Nitrogen Species ◽  
Eligibility Criteria ◽  
Crocus Sativus L

Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is a growing interest in Crocus sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico. Objective: The present study aims to address the anti-toxicant role of Crocus sativus L. in the cases of toxin and drug toxification. Materials and Methods: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. Results: The authors focused on literature concerning the role of Crocus Sativus L. as an anti-toxicant agent. Literature review showed that Saffron is a potent anti-toxicant agent with a plethora of applications ranging from anti-oxidant properties, to chemotherapy protective effects. Conclusion: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as anti-toxicant, chemotherapy-induced protection and toxin protection.

Sign in / Sign up

Export Citation Format

Share Document