Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone

2006 ◽  
Vol 168 (2) ◽  
pp. 323-325 ◽  
Author(s):  
Sergio Scaccianoce ◽  
Paola Del Bianco ◽  
Giovanna Paolone ◽  
Daniele Caprioli ◽  
Antonella M.E. Modafferi ◽  
...  
Keyword(s):  
Social Isolation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Plasma Corticosterone

scholarly journals Social Defeat Stress during Early Adolescence Confers Resilience against a Single Episode of Prolonged Stress in Adult Rats

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 360
Author(s):  
Giulia Federica Mancini ◽  
Enrico Marchetta ◽  
Irene Pignani ◽  
Viviana Trezza ◽  
Patrizia Campolongo
Keyword(s):  
Spatial Memory ◽  
Early Adolescence ◽  
Neurotrophic Factor ◽  
Social Defeat ◽  
Brain Derived Neurotrophic Factor ◽  
Plasma Corticosterone ◽  
Social Defeat Stress ◽  
Single Episode ◽  
Second Hit ◽  
Prolonged Stress

Early-life adverse experiences (first hit) lead to coping strategies that may confer resilience or vulnerability to later experienced stressful events (second hit) and the subsequent development of stress-related psychopathologies. Here, we investigated whether exposure to two stressors at different stages in life has long-term effects on emotional and cognitive capabilities, and whether the interaction between the two stressors influences stress resilience. Male rats were subjected to social defeat stress (SDS, first hit) in adolescence and to a single episode of prolonged stress (SPS, second hit) in adulthood. Behavioral outcomes, hippocampal expression of brain-derived neurotrophic factor, and plasma corticosterone levels were tested in adulthood. Rats exposed to both stressors exhibited resilience against the development of stress-induced alterations in emotional behaviors and spatial memory, but vulnerability to cued fear memory dysfunction. Rats subjected to both stressors demonstrated resilience against the SDS-induced alterations in hippocampal brain-derived neurotrophic factor expression and plasma corticosterone levels. SPS alone altered locomotion and spatial memory retention; these effects were absent in SDS-exposed rats later exposed to SPS. Our findings reveal that exposure to social stress during early adolescence influences the ability to cope with a second challenge experienced later in life.

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

2019 ◽  
Vol 366 ◽  
pp. 36-44 ◽  
Author(s):  
Juliano Viana Borges ◽  
Betânia Souza de Freitas ◽  
Vinicius Antoniazzi ◽  
Cristophod de Souza dos Santos ◽  
Kelem Vedovelli ◽  
...  
Keyword(s):  
Social Support ◽  
Social Isolation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Epigenetic Mechanisms ◽  
And Behavior

Brain Derived Neurotrophic Factor Gene Polymorphism Associated With Language Acquisition

2007 ◽  
Author(s):  
Scott H. Fraundorf ◽  
Brad E. Sheese ◽  
Lauren K. White ◽  
Mary K. Rothbart ◽  
Michael I. Posner
Keyword(s):  
Language Acquisition ◽  
Gene Polymorphism ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene
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