Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease

2005 ◽  
Vol 156 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Elisa Ognibene ◽  
Silvia Middei ◽  
Stefania Daniele ◽  
Walter Adriani ◽  
Orlando Ghirardi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Spatial Memory ◽  
Behavioral Disinhibition ◽  
Model Of Alzheimer’S Disease

P1-031: Age-related cerebral changes of brain-derived neurotrophic factor in a model of Alzheimer's disease in APP23 transgenic mice

2006 ◽  
Vol 2 ◽  
pp. S103-S103
Author(s):  
Olaf Schulte-Herbrüggen ◽  
Uwe Deicke ◽  
Uwe Otten ◽  
Dorothee Abramowski ◽  
Matthias Staufenbiel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Model Of Alzheimer’S Disease ◽  
Age Related

Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease

2016 ◽  
Vol 19 (10) ◽  
pp. 475-483 ◽  
Author(s):  
Selvaraju Subash ◽  
Musthafa Mohamed Essa ◽  
Nady Braidy ◽  
Ahood Al-Jabri ◽  
Ragini Vaishnav ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Mice Model ◽  
Learning Skills ◽  
Model Of Alzheimer’S Disease

Effect of Camellia sinensis on Spatial Memory in a Rat Model of Alzheimer’s Disease

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Tahereh Mahmoodzadeh ◽  
Maryam Haji Khasem Kashani ◽  
Hassan Ramshini ◽  
Alireza Moslem ◽  
Mohammad Mohammad-Zadeh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Memory ◽  
Camellia Sinensis ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease

scholarly journals Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression

2019 ◽  
Author(s):  
Katia Martínez-González ◽  
Azul Islas-Hernández ◽  
José Darío Martínez-Ezquerro ◽  
Federico Bermúdez-Rattoni ◽  
Paola Garcia-delaTorre
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Telomere Length ◽  
Brain Tissue ◽  
Murine Model ◽  
Blood Cells ◽  
Model Of Alzheimer’S Disease ◽  
And Oxidative Stress

AbstractAlzheimer’s Disease (AD) is the most common cause of dementia and aging is its major risk factor. Changes in telomere length have been associated with aging and some degenerative diseases. Our aim was to explore some of the molecular changes caused by the progression of AD in a transgenic murine model (3xTg-AD; B6; 129-Psen1 <tm1Mpm> Tg (APPSwe, tauP301L) 1Lfa). Telomere length was assessed by qPCR in both brain tissue and peripheral blood cells and compared between three age groups: 5, 9, and 13 months. In addition, a possible effect of oxidative stress on telomere length and AD progression was explored. Shorter telomeres were found in blood cells of older transgenic mice compared to younger and wild type mice but no changes in telomere length in the hippocampus. An increase in oxidative stress with age was found for all strains but no correlation was found between oxidative stress and shorter telomere length for transgenic mice. Telomere length and oxidative stress are affected by AD progression in the 3xTg-AD murine model. Changes in blood cells are more noticeable than changes in brain tissue, suggesting that systemic changes can be detected early in the disease in this murine model.

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