Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task

2003 ◽  
Vol 146 (1-2) ◽  
pp. 131-144 ◽  
Author(s):  
D.M Eagle ◽  
T.W Robbins
Keyword(s):  
Prefrontal Cortex ◽  
Reaction Time ◽  
Nucleus Accumbens ◽  
Medial Prefrontal Cortex ◽  
Inhibitory Control ◽  
Reaction Time Task ◽  
Stop Signal ◽  
Nucleus Accumbens Core ◽  
Time Task ◽  
Stop Signal Reaction Time

scholarly journals Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus

2007 ◽  
Vol 18 (1) ◽  
pp. 178-188 ◽  
Author(s):  
D. M. Eagle ◽  
C. Baunez ◽  
D. M. Hutcheson ◽  
O. Lehmann ◽  
A. P. Shah ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Reaction Time ◽  
Task Performance ◽  
Subthalamic Nucleus ◽  
Reaction Time Task ◽  
Stop Signal ◽  
Time Task ◽  
Stop Signal Reaction Time

scholarly journals Role of the medial prefrontal cortex and nucleus accumbens in an operant model of checking behaviour and uncertainty

2017 ◽  
Vol 1 ◽  
pp. 239821281773340 ◽  
Author(s):  
Camilla d’Angelo ◽  
Dawn M. Eagle ◽  
Cristina-M. Coman ◽  
Trevor W. Robbins
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Obsessive Compulsive Disorder ◽  
Medial Prefrontal Cortex ◽  
Nucleus Accumbens Core ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Observing Response ◽  
Response Task ◽  
Accumbens Core

Background: Excessive checking is a common, debilitating symptom of obsessive–compulsive disorder. To further examine cognitive processes underpinning checking behaviour, and clarify how and why checking develops, we designed a novel operant paradigm for rats, the observing response task. The present study used the observing response task to investigate checking behaviour following excitotoxic lesions of the medial prefrontal cortex, nucleus accumbens core and dorsal striatum, brain regions considered to be of relevance to obsessive–compulsive disorder. Methods: In the observing response task, rats pressed an ‘observing’ lever for information (provided by light onset) about the location of an ‘active’ lever that provided food reinforcement. Following training, rats received excitotoxic lesions of the regions described above and performance was evaluated post-operatively before histological processing. Results: Medial prefrontal cortex lesions selectively increased functional checking with a less-prominent effect on non-functional checking and reduced discrimination accuracy during light information periods. Rats with nucleus accumbens core lesions made significantly more checking responses than sham-lesioned rats, including both functional and non-functional checking. Dorsal striatum lesions had no direct effect on checking per se, but reduced both active and inactive lever presses, and therefore changed the relative balance between checking responses and instrumental responses. Conclusions: These results suggest that the medial prefrontal cortex and nucleus accumbens core are important in the control of checking, perhaps via their role in processing uncertainty of reinforcement, and that dysfunction of these regions may therefore promote excessive checking behaviour, possibly relevant to obsessive-compulsive disorder.

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