scholarly journals Pre-Hematopoietic Stem Cell Transplantation Lung Computed Tomography as an Alternative to the Pulmonary Function Test during the COVID-19 Pandemic

2020 ◽  
Vol 26 (12) ◽  
pp. 2318-2322
Author(s):  
Masaharu Tamaki ◽  
Hideki Nakasone ◽  
Tadao Aikawa ◽  
Yuhei Nakamura ◽  
Masakatsu Kawamura ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Pulmonary Function ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Pulmonary Function Test ◽  
Hematopoietic Stem ◽  
Function Test

scholarly journals Early Lung Computed Tomography Scan after Allogeneic Hematopoietic Stem Cell Transplantation

2016 ◽  
Vol 22 (8) ◽  
pp. 1511-1516
Author(s):  
Marie Alice Cornetto ◽  
Sylvie Chevret ◽  
Sarah Abbes ◽  
Constance de Margerie-Mellon ◽  
Claire Hussenet ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Computed Tomography Scan ◽  
Hematopoietic Stem ◽  
Tomography Scan

Pulmonary Function in Pediatric survivors of non-Malignant Disorders after Allogeneic Hematopoietic Stem Cell Transplantation.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2136-2136 ◽  
Author(s):  
Megan S Motosue ◽  
Hiroto Inaba ◽  
Jianmin Pan ◽  
Dennis C. Stokes ◽  
Deo Kumar Srivastava ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Pulmonary Function ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Older Age ◽  
Hematopoietic Stem ◽  
Predictive Values

Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is used to treat children with non-malignant disorders. As the number of survivors of non-malignant disorders after allogeneic HCST rises, monitoring late sequelae becomes increasingly important. However, no studies have solely targeted this population especially on pulmonary function. We therefore performed a long-term prospective study of pulmonary function in 38 pediatric survivors of non-malignant disorders after allogeneic HCST, including aplastic anemia (n = 15), sickle cell anemia (n = 13), immunodeficiency syndromes (n = 8), Hurler syndrome (n = 1), and osteopetrosis (n = 1). A total of 260 pulmonary function tests were conducted on the patients. Older age of recipients was associated with poorer pulmonary function; lower ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC; p < 0.0001); lower percent predictives in FEV1 (p = 0.0178), forced expiratory flow (FEF25–75%; p < 0.0001), FVC (p = 0.0299), and diffusion capacity corrected for hemoglobin (DLCOcorr; p = 0.0079); higher ratio of residual volume and total lung capacity (RV/TLC; p = 0.0193); and higher percent predictives in RV (p = 0.0308) and functional residual capacity (FRC; p = 0.0489). The following percent predictive values declined over time (median follow-up: 8 years): FEF25–75% (p = 0.0064), RV (p = 0.0134), FRC (p = 0.003), FVC (p = 0.0004), TLC (p = 0.0248), and DLCOcorr (p = 0.0077). Also, busulfan use was associated with lower FEV1 (p = 0.026), FVC (p = 0.0194), and DLCOcorr (p = 0.0105). This study underscores the need to monitor risk-adapted long-term lung function and provide early interventions in this vulnerable population, especially for those who received HSCT at an older age or had been administered busulfan.

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