scholarly journals Acute Kidney Injury in Children after Hematopoietic Cell Transplantation Is Associated with Elevated Urine CXCL10 and CXCL9

2020 ◽  
Vol 26 (7) ◽  
pp. 1266-1272
Author(s):  
Daniella Levy Erez ◽  
Michelle R. Denburg ◽  
Simisola Afolayan ◽  
Sonata Jodele ◽  
Gregory Wallace ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Kidney Injury ◽  
Hematopoietic Cell

scholarly journals Recent Advances of Acute Kidney Injury in Hematopoietic Cell Transplantation

2022 ◽  
Vol 12 ◽  
Author(s):  
Masahiro Miyata ◽  
Kazunobu Ichikawa ◽  
Eri Matsuki ◽  
Masafumi Watanabe ◽  
Daniel Peltier ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Immune Cell ◽  
Kidney Injury ◽  
Major Complication ◽  
Hematopoietic Cell ◽  
Sinusoidal Obstruction Syndrome ◽  
Nephrotoxic Drugs

Acute kidney injury (AKI) is a common complication of allogeneic hematopoietic cell transplantation (allo-HCT) and is associated with non-relapse mortality (NRM) and quality of life (QOL). Multiple factors may contribute to AKI during allo-HCT and are often present at the same time making it difficult to determine the cause of AKI in each patient. Nephrotoxic drugs, infections, thrombotic microangiopathy (TMA), and sinusoidal obstruction syndrome (SOS) are well described causes of AKI during allo-HCT. Acute graft-versus-host disease (aGVHD) is a major complication of allo-HCT that mainly targets the intestines, liver, and skin. However, recent studies suggest aGVHD may also attack the kidney and contribute to AKI following allo-HCT. For example, severe aGVHD is associated with AKI, suggesting a link between the two. In addition, animal models have shown donor immune cell infiltration and increased expression of inflammatory cytokines in recipient kidneys after allo-HCT. Therefore, aGVHD may also target the kidney and contribute to AKI following allo-HCT. Herein, we describe the etiology, diagnosis, risk factors, pathophysiology, prevention, and treatment of renal injury after allo-HCT. In addition, we highlight emerging evidence that aGVHD may contribute to the development of AKI after allo-HCT.

scholarly journals Impact of Acute Kidney Injury on Long-Term Mortality after Nonmyeloablative Hematopoietic Cell Transplantation

2008 ◽  
Vol 14 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Chirag R. Parikh ◽  
Sri G. Yarlagadda ◽  
Barry Storer ◽  
Mohamed Sorror ◽  
Rainer Storb ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Kidney Injury ◽  
Hematopoietic Cell ◽  
Long Term Mortality
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