scholarly journals Celiac Disease Risk Determined By HLA-DQ Genotype Protects Against Gvhd in a Dose-Responsive Manner

2020 ◽  
Vol 26 (3) ◽  
pp. S186
Author(s):  
Susan McClory ◽  
Viviane C. Cahen ◽  
Yimei Li ◽  
Jamie L. Duke ◽  
Dimitri S. Monos ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Disease Risk ◽  
Hla Dq

Celiac disease risk stratification based on HLA-DQ heterodimer (HLA-DQA1 ~ DQB1) typing in a large cohort of adults with suspected celiac disease

2020 ◽  
Vol 81 (2-3) ◽  
pp. 59-64 ◽  
Author(s):  
Rok Seon Choung ◽  
John R. Mills ◽  
Melissa R. Snyder ◽  
Joseph A. Murray ◽  
Manish J. Gandhi
Keyword(s):  
Celiac Disease ◽  
Risk Stratification ◽  
Disease Risk ◽  
Large Cohort ◽  
Hla Dq ◽  
Hla Dqa1

scholarly journals Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Lucas Malta Almeida ◽  
Lenora Gandolfi ◽  
Riccardo Pratesi ◽  
Rosa Harumi Uenishi ◽  
Fernanda Coutinho de Almeida ◽  
...  
Keyword(s):  
At Risk ◽  
T Cells ◽  
Celiac Disease ◽  
Disease Risk ◽  
Disease Development ◽  
Immunogenic Peptides ◽  
Immune Mediated ◽  
Hla Dq ◽  
Genetically Determined

Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p<0.05. Disease risk was expressed as 1 : N for each HLA-DQ category described at this study. Results. DQ2.5 and/or DQ8 were detected in 224 celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p<0.0001). The disease risk gradient ranged from 1 : 3014 to 1 : 7. Conclusion. Our study allowed the determination of a risk gradient for celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5.

scholarly journals Influence of Environmental and Genetic Factors Linked to Celiac Disease Risk on Infant Gut Colonization by Bacteroides Species

2011 ◽  
Vol 77 (15) ◽  
pp. 5316-5323 ◽  
Author(s):  
Ester Sánchez ◽  
Giada De Palma ◽  
Amalia Capilla ◽  
Esther Nova ◽  
Tamara Pozo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Genetic Risk ◽  
Disease Risk ◽  
Feeding Practice ◽  
Content Type ◽  
High Genetic Risk ◽  
Gut Colonization ◽  
Hla Dq ◽  
Breast Fed ◽  
Milk Feeding

ABSTRACTCeliac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors whose interaction might influence disease risk. The aim of this study was to determine the effects of milk-feeding practices and the HLA-DQ genotype on intestinal colonization ofBacteroidesspecies in infants at risk of CD development. This study included 75 full-term newborns with at least one first-degree relative suffering from CD. Infants were classified according to milk-feeding practice (breast-feeding or formula feeding) and HLA-DQ genotype (high or low genetic risk). Stools were analyzed at 7 days, 1 month, and 4 months by PCR and denaturing gradient gel electrophoresis (DGGE). TheBacteroidesspecies diversity index was higher in formula-fed infants than in breast-fed infants. Breast-fed infants showed a higher prevalence ofBacteroides uniformisat 1 and 4 months of age, while formula-fed infants had a higher prevalence ofB. intestinalisat all sampling times, ofB. caccaeat 7 days and 4 months, and ofB. plebeiusat 4 months. Infants with high genetic risk showed a higher prevalence ofB. vulgatus, while those with low genetic risk showed a higher prevalence ofB. ovatus,B. plebeius, andB. uniformis. Among breast-fed infants, the prevalence ofB. uniformiswas higher in those with low genetic risk than in those with high genetic risk. Among formula-fed infants, the prevalence ofB. ovatusandB. plebeiuswas increased in those with low genetic risk, while the prevalence ofB. vulgatuswas higher in those with high genetic risk. The results indicate that both the type of milk feeding and the HLA-DQ genotype influence the colonization process ofBacteroidesspecies, and possibly the disease risk.

scholarly journals Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease

2021 ◽  
Vol 14 ◽  
pp. 117863882110606
Author(s):  
Avinash Lomash ◽  
Anupa Prasad ◽  
Raghvendra Singh ◽  
Somesh Kumar ◽  
Rishi Gupta ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Hla Typing ◽  
Assessment And Evaluation ◽  
Plasma Citrulline ◽  
Hla Dq ◽  
Median Plasma ◽  
Latent Potential ◽  
Damage Extent ◽  
Increasing Trends

Introduction: Citrulline is regarded as a biomarker for celiac disease (CD). Its utility for assessment and evaluation of additive predictive value for latent, potential CD and first degree relatives (FDRs) needs exploration. Method: Consecutive 558 index cases diagnosed as per European Society for Pediatric Gastroenterology and Nutrition (ESPGHAN) 2012 guidelines and their 1565 FDRs were evaluated over five and half year period. Serology negative FDRs at initial visit and follow ups were served as controls. HLA typing for DQ2 and DQ8 genotypes, along with plasma and dried blood spot (DBS) filter paper citrulline were evaluated. Results: Median plasma citrulline values were 20.1 and 37.33 µMol/l in cases and controls ( P < .001). Cut off values for Marsh grade 3a, 3b, and 3c were 35.0, 32.8, 25.26 µMol/l in CD patients and 36.51, 30.10, 25.26 µMol/l in biopsy proven FDR. Increasing trends of plasma citrulline levels with decreasing tTG-IgA levels were observed on follow up. Low plasma citrulline levels were observed with HLA DQ 2.5 genotype ( P < .05). Agreement between DBS and plasma citrulline was 94.8%. Conclusion: Citrulline is a good surrogate biomarker for identification of histopathological grade of damage, extent of mucosal recovery and has negative correlation with tTG-IgA. It identifies the silent and latent phase of CD. DBS citrulline provides adequate information and can be used for monitoring CD patients at remote locations.

Amerindian Mtdna Haplogroups And Celiac Disease Risk HLA Haplotypes In Mixed Blood Latin American Patients

2011 ◽  
pp. 1 ◽  
Author(s):  
Alejandra Parada ◽  
Magdalena Araya ◽  
Francisco Pérez-Bravo ◽  
Marco Méndez ◽  
Adriana Mimbacas ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Latin American ◽  
Disease Risk ◽  
Mtdna Haplogroups ◽  
Mixed Blood ◽  
Hla Haplotypes

Regional variation in celiac disease risk within Sweden revealed by the nationwide prospective incidence register

2008 ◽  
Vol 98 (2) ◽  
pp. 337-342 ◽  
Author(s):  
Cecilia Olsson ◽  
Hans Stenlund ◽  
Agneta Hörnell ◽  
Olle Hernell ◽  
Anneli Ivarsson
Keyword(s):  
Celiac Disease ◽  
Regional Variation ◽  
Disease Risk

Helicobacter pylori infection and occurrence of celiac disease in subjects HLA ‐ DQ 2/ DQ 8 positive: A prospective study

Helicobacter ◽  
2018 ◽  
Vol 23 (2) ◽  
pp. e12465 ◽  
Author(s):  
Maria P. Dore ◽  
Roberta Salis ◽  
Maria F. Loria ◽  
Vincenzo Villanacci ◽  
Gabrio Bassotti ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Celiac Disease ◽  
Prospective Study ◽  
Helicobacter Pylori Infection ◽  
Hla Dq ◽  
A Prospective Study

Usefulness of HLA-DQ genotyping for the diagnosis of celiac disease in a selected population of patients with clinical symptoms and positive serological tests

2014 ◽  
Vol 46 ◽  
pp. e109
Author(s):  
Silvia Nastasio ◽  
Lorenza Lepore ◽  
Elena Chiocca ◽  
Giulia Marsalli ◽  
Silvia Ghione ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Symptoms ◽  
Serological Tests ◽  
Hla Dq
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