scholarly journals Clinical Impacts of Using Serum IL-6 Level as an Indicator of Cytokine Release Syndrome after HLA-Haploidentical Transplantation with Post-Transplantation Cyclophosphamide

2019 ◽  
Vol 25 (10) ◽  
pp. 2061-2069 ◽  
Author(s):  
Mitsutaka Nishimoto ◽  
Asao Hirose ◽  
Hideo Koh ◽  
Mika Nakamae ◽  
Satoru Nanno ◽  
...  
Keyword(s):  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Post Transplantation ◽  
Haploidentical Transplantation

scholarly journals Timing of Initiation of Calcineurin Inhibitors in Pediatric Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: Effects on Survival, Relapse, and Cytokine Release Syndrome

2021 ◽  
Author(s):  
Vedat Uygun ◽  
Gülsün Karasu ◽  
Koray Yalçın ◽  
Seda Ozturkmen ◽  
Hayriye Daloğlu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Calcineurin Inhibitors ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Post Transplantation ◽  
Acceptable Alternative ◽  
Haploidentical Transplantation ◽  
Timing Of Initiation ◽  
Overall Survival Analysis ◽  
Matched Donor

Background: The use of unmanipulated haploidentical stem cell transplantations (haplo-HSCT) with post-transplant cyclophosphamide (PTCY) in children has emerged as an acceptable alternative to the patients without a matched donor. However, the timing of calcineurin inhibitors (CNI) used in combination with PTCY is increasingly becoming a topic of controversy. Method: We evaluated 49 children with acute leukemia who underwent unmanipulated haplo-HSCT with PTCY according to the initiation day of CNIs (pre- or post-CY). Results: There were no significant differences in the overall survival analysis between the two groups. The cumulative incidence of relapse at 2 years was 21.2% in the pre-CY group and 38.9% in the post-CY group (p=0.33). Cytokine release syndrome (CRS) was observed more frequently in the post-CY group (p=0.04). The OS and EFS at 2 years in patients with and without CRS in the pre-Cy group were 42.9% vs 87.5% (p=0.04) and 38.1% vs 87.5% (p=0.04), respectively. Conclusion: Our study shows that the argument for starting CNI administration after CY is tenuous, and the rationale for not starting CNI before CY needs to be reconsidered.

scholarly journals Timing of Initiation of Calcineurin Inhibitors in Pediatric Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: Effects on Survival, Relapse, and Cytokine Release Syndrome

2021 ◽  
Author(s):  
Vedat Uygun ◽  
Gulsun Karasu ◽  
Koray Yalçın ◽  
Seda Öztürkmen ◽  
Hayriye Daloglu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Calcineurin Inhibitors ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Post Transplantation ◽  
Acceptable Alternative ◽  
Haploidentical Transplantation ◽  
Timing Of Initiation ◽  
Overall Survival Analysis ◽  
Matched Donor

Abstract The use of unmanipulated haploidentical stem cell transplantations (haplo-HSCT) with post-transplant cyclophosphamide (PTCY) in children has emerged as an acceptable alternative to the patients without a matched donor. However, the timing of calcineurin inhibitors (CNI) used in combination with PTCY is increasingly becoming a topic of controversy. We evaluated 49 children with acute leukemia who underwent unmanipulated haplo-HSCT with PTCY according to the initiation day of CNIs (pre- or post-CY). There were no significant differences in the overall survival analysis between the two groups. The cumulative incidence of relapse at 2 years was 21.2% in the pre-CY group and 38.9% in the post-CY group (p = 0.33). Cytokine release syndrome (CRS) was observed more frequently in the post-CY group. Our study shows that the argument for starting CNI administration after CY is tenuous, and the rationale for not starting CNI before CY needs to be reconsidered.

scholarly journals Cytokine Release Syndrome after Peripheral Blood T-Cell Replete Haploidentical Transplantation Is Not Prevented By Dexamethasone and Limits Its Full-Outpatient Conduction

2019 ◽  
Vol 25 (3) ◽  
pp. S136-S137
Author(s):  
Perla R. Colunga-Pedraza ◽  
Andrés Gómez-De León ◽  
Julia E. Colunga-Pedraza ◽  
Paola Santana-Hernández ◽  
Emmanuel Bugarín-Estrada ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Haploidentical Transplantation

scholarly journals Peripheral Blood Grafts for T Cell–Replete Haploidentical Transplantation Increase the Incidence and Severity of Cytokine Release Syndrome

2018 ◽  
Vol 24 (8) ◽  
pp. 1664-1670 ◽  
Author(s):  
Renju V. Raj ◽  
Mehdi Hamadani ◽  
Aniko Szabo ◽  
Marcelo C. Pasquini ◽  
Nirav N. Shah ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Haploidentical Transplantation
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