scholarly journals Efficacy of Allogeneic Hematopoietic Cell Transplantation in Human T Cell Lymphotropic Virus Type 1–Associated Adult T Cell Leukemia/Lymphoma: Results of a Systematic Review/Meta-Analysis

2019 ◽  
Vol 25 (8) ◽  
pp. 1695-1700 ◽  
Author(s):  
Madiha Iqbal ◽  
Tea Reljic ◽  
Farina Klocksieben ◽  
Taimur Sher ◽  
Ernesto Ayala ◽  
...  
Keyword(s):  
Systematic Review ◽  
T Cell ◽  
Cell Transplantation ◽  
Virus Type ◽  
Hematopoietic Cell Transplantation ◽  
Meta Analysis ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience

2008 ◽  
Vol 49 (3) ◽  
pp. 439-446 ◽  
Author(s):  
Deirdre O'Mahony ◽  
Indranil Debnath ◽  
John Janik ◽  
Dara Aisner ◽  
Elaine Jaffe ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Cardiac Involvement ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

scholarly journals Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan

2018 ◽  
Vol 6 (25) ◽  
Author(s):  
Takuro Fukumoto ◽  
Emi Ikebe ◽  
Masao Ogata ◽  
Kazuhiro Kohno ◽  
Madoka Kuramitsu ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACT We report two complete proviral genome sequences of human T-cell leukemia virus type 1 (HTLV-1) isolated from the peripheral blood specimens of acute type adult T-cell leukemia (ATL) patients in Oita Prefecture, Japan.

scholarly journals Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
David Sibon ◽  
Olivier Cassar ◽  
Isabelle Duga ◽  
Chantal Brouzes ◽  
David Ghez ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Sexual Transmission ◽  
Central Africa ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Cell Neoplasm

Abstract Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding.

scholarly journals A critical analysis of prognostic factors in North American patients with human T-cell lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma

Cancer ◽  
2010 ◽  
Vol 116 (14) ◽  
pp. 3438-3446 ◽  
Author(s):  
Adrienne A. Phillips ◽  
Iuliana Shapira ◽  
Robert D. Willim ◽  
Jasotha Sanmugarajah ◽  
William B. Solomon ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
T Cell ◽  
Virus Type ◽  
North American ◽  
Critical Analysis ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier

2015 ◽  
Vol 42 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Naoki Fuchi ◽  
Kiyonori Miura ◽  
Yoshitaka Imaizumi ◽  
Hiroo Hasegawa ◽  
Katsunori Yanagihara ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
T Cell ◽  
Virus Type ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

scholarly journals Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways

2015 ◽  
Vol 89 (9) ◽  
pp. 4880-4893 ◽  
Author(s):  
Jinhee Hyun ◽  
Juan Carlos Ramos ◽  
Ngoc Toomey ◽  
Siddharth Balachandran ◽  
Alfonso Lavorgna ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Host Defense ◽  
Innate Immune ◽  
Type I ◽  
Type I Ifn ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

ABSTRACTHuman T-cell lymphotropic virus type I (HTLV-1) is an oncogenic retrovirus considered to be the etiological agent of adult T-cell leukemia (ATL). The viral transactivator Tax is regarded as the oncoprotein responsible for contributing toward the transformation process. Here, we demonstrate that Tax potently inhibits the activity of DEx(D/H) box helicases RIG-I and MDA5 as well as Toll-dependent TIR-domain-containing adapter-inducing interferon-β (TRIF), which function as cellular sensors or mediators of viral RNA and facilitate innate immune responses, including the production of type I IFN. Tax manifested this function by binding to the RIP homotypic interaction motif (RHIM) domains of TRIF and RIP1 to disrupt interferon regulatory factor 7 (IRF7) activity, a critical type I IFN transcription factor. These data provide further mechanistic insight into HTLV-1-mediated subversion of cellular host defense responses, which may help explain HTLV-1-related pathogenesis and oncogenesis.IMPORTANCEIt is predicted that up to 15% of all human cancers may involve virus infection. For example, human T-cell lymphotropic virus type 1 (HTLV-1) has been reported to infect up to 25 million people worldwide and is the causative agent of adult T-cell leukemia (ATL). We show here that HTLV-1 may be able to successfully infect the T cells and remain latent due to the virally encoded product Tax inhibiting a key host defense pathway. Understanding the mechanisms by which Tax subverts the immune system may lead to the development of a therapeutic treatment for HTLV-1-mediated disease.

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