scholarly journals T Cell Repertoire Evolution after Allogeneic Bone Marrow Transplantation: An Organizational Perspective

2019 ◽  
Vol 25 (5) ◽  
pp. 868-882 ◽  
Author(s):  
Jeremy A. Meier ◽  
Mahdee Haque ◽  
Mohamed Fawaz ◽  
Hamdi Abdeen ◽  
David Coffey ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Organizational Perspective

T-cell repertoire complexity after allogeneic bone marrow transplantation

1996 ◽  
Vol 48 (1-2) ◽  
pp. 135-138 ◽  
Author(s):  
Etienne Roux ◽  
Claudine Helg ◽  
Bernard Chapuis ◽  
Michel Jeannet ◽  
Eddy Roosnek
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
T Cell Repertoire ◽  
Cell Repertoire

Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell–depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire

Blood ◽  
2000 ◽  
Vol 95 (12) ◽  
pp. 3990-3995 ◽  
Author(s):  
Stephanie Verfuerth ◽  
Karl Peggs ◽  
Paulomi Vyas ◽  
Lorna Barnett ◽  
Richard J. O'Reilly ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Immune Reconstitution ◽  
Immunosuppressive Treatment ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Donor Lymphocyte Infusions

Abstract Delayed immune reconstitution after allogeneic bone marrow transplantation (BMT) with associated infection is a major cause of morbidity and mortality. We used third complementarity region (CDR3) size spectratyping as a tool for monitoring T-cell repertoire reconstitution in 19 patients over a median time of 40 months after T-cell–depleted allogeneic BMT for chronic myeloid leukemia (CML). Furthermore, the effect of donor lymphocyte infusions (DLI) for the treatment of relapse in 18 of the 19 patients was analyzed. All BMT recipients had irregular spectratypes in the first 3- to -6 months after transplant. These evolved to more normal patterns by 12 months after transplant and continued to improve thereafter. In approximately a third of the patients, it took 2 to 3 years for all spectratypes to normalize, whereas in the other two thirds, some abnormal spectratypes persisted even after several years. In 9 patients, there was no immediate change in the CDR3 size profiles after DLI. In 3 patients, spectratypes improved slightly after DLI, whereas in 6 patients, spectratypes became more restricted and irregular. Overall, T-cell spectratypes in BMT patients were characterized by instability over time and in patients with graft-versus-host disease (GVHD), this was even more exaggerated. Several factors, such as pre-BMT conditioning, T-cell depletion of the donor marrow, loss of thymic function in adults, exposure to infectious agents, GVHD, and immunosuppressive treatment, are likely contributors to the delay in T-cell–repertoire reconstitution.

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