scholarly journals Optimizing Plerixafor Algorithm for Mobilization of Peripheral Blood Stem Cells in Patients with Multiple Myeloma Requiring Tandem Transplants

2019 ◽  
Vol 25 (3) ◽  
pp. S218-S219
Author(s):  
Darren Johnson ◽  
Minoo Battiwalla ◽  
Misty Evans ◽  
Tiffany Egan ◽  
Roy S Graham ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cells ◽  
Blood Stem Cells

scholarly journals Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients

Leukemia ◽  
2007 ◽  
Vol 22 (6) ◽  
pp. 1280-1281 ◽  
Author(s):  
A Mazumder ◽  
J Kaufman ◽  
R Niesvizky ◽  
S Lonial ◽  
D Vesole ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cells ◽  
Blood Stem Cells

Ex-Vivo Expanded Peripheral Blood Stem Cells (EVEC) Compared with Un Manipulated Peripheral Blood Stem Cells (PBSC) Autologous Transplantation for Multiple Myeloma: A Pair Match Analysis.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 502-502 ◽  
Author(s):  
Noel-Jean Milpied ◽  
Gerald Marit ◽  
Bernard Dazey ◽  
Jean-Michel Boiron ◽  
Zoran Ivanovic ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Peripheral Blood ◽  
Ex Vivo ◽  
High Dose ◽  
Peripheral Blood Stem Cells ◽  
Cd34 Cells ◽  
Blood Stem Cells

Abstract Abstract 502 Autologous stem cell transplantation with PBSC after high-dose chemotherapy remains standard therapy for patients with symptomatic Multiple Myeloma (MM). Strategies to minimize complications could significantly reduce the morbidity of that procedure. One possibility could be to shorten the duration of induced neutropenia through the injection of an ex-vivo expanded graft. Nineteen patients (pts) received EVEC after high-dose Melphalan (HDM) (200 mg/m2) as the only graft. The ex-vivo expanded procedure has been described elsewhere (Boiron et al. Transfusion 2006 and Ivanovic et al. Transfusion 2006). Briefly, thawed peripheral blood CD 34+ cells collected after G-CSF mobilisation and selected with immunomagnetic devices were incubated for 10 days in a serum free medium (Maco Biotech HP01) with Stem Cell Factor (Amgen), G-CSF (Amgen) and TPO (Amgen: 7 pts; Cellgenix:12 pts). The expanded cells were then thoroughly washed and injected 48h after the HDM injection. The ex-vivo expansion lead to a median fold of 5,4 for CD34+ cells (1,3-11,8); 118 for CD33+ (1-703880); 3386 for CD14+ (4-101075); 28,5 for CD13+ (10-703880) and 13 for CFUs (6-21). The median N° of CD34+ cells injected was 14×10e6/kg (5,3-48). The results of these transplants were compared to those achieved in 38 pts who received unmanipulated PBSC after HDM. Pts and controls were matched for age, sex, stage of the disease, first line chemotherapy ( VAD or VD) status of the disease at time of transplant, year of transplant, time between diagnosis and transplant, CD34+ mobilisation technique (HD cytoxan + G-CSF or G-CSF alone) and the median N° of total nucleated cells and of CD34+ collected. The results are summarized on the table: There was no secondary neutropenia in the patients who received EVEC. With a median FU of the entire cohort of 30 m, the median OS for pts who received their first transplant with EVEC and with PBSC is 69 m and not reached respectively (p=NS), the median PFS is 18 m and 27 m (p = NS) and the median time to progression is 14 m and 15 m (p=NS). Conclusion: EVEC is feasible, safe and reduce significantly the morbidity of autologous stem cell transplantation after HDM for multiple myeloma. Disclosures: Milpied: Amgen France: Honoraria.

Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma

Transfusion ◽  
2006 ◽  
Vol 46 (8) ◽  
pp. 1417-1423 ◽  
Author(s):  
Frank Kroschinsky ◽  
Kristina Holig ◽  
Uwe Platzbecker ◽  
Kirsten Poppe-Thiede ◽  
Rainer Ordemann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Single Dose ◽  
Malignant Lymphoma ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cells ◽  
Blood Stem Cells
Sign in / Sign up

Export Citation Format

Share Document