scholarly journals Long-Term Follow Up (LTFU) for Blood and Marrow Transplant (BMT) Survivors: Building Collaborative Practice between a Comprehensive Cancer Center and Community Oncology Nurses

2018 ◽  
Vol 24 (3) ◽  
pp. S472-S473
Author(s):  
Mihkai Wickline ◽  
Denae Davis ◽  
Rose Rivett ◽  
Larrisa Murphy ◽  
Claudine Schneider
Keyword(s):  
Marrow Transplant ◽  
Oncology Nurses ◽  
Collaborative Practice ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Blood And Marrow Transplant ◽  
Community Oncology ◽  
Long Term Follow Up

Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2055-2061 ◽  
Author(s):  
Kieren A. Marr ◽  
Kristy Seidel ◽  
Monica A. Slavin ◽  
Raleigh A. Bowden ◽  
H. Gary Schoch ◽  
...  
Keyword(s):  
Invasive Candidiasis ◽  
Fungal Infections ◽  
Controlled Trial ◽  
Marrow Transplant ◽  
Blood And Marrow Transplant ◽  
Long Term Follow Up ◽  
Fluconazole Prophylaxis ◽  
Overall Survival Benefit

Two randomized, placebo-controlled trials previously showed that fluconazole (400 mg/d) administered prophylactically decreases the incidence of candidiasis in blood and marrow transplant (BMT) recipients. However, there exists conflicting data regarding the optimal duration of fluconazole administration, specifically whether prophylaxis through acute graft-versus-host disease (GVHD) results in improved survival in allograft recipients. Reported here are the results of long-term follow-up and a detailed analysis of invasive candidiasis and candidiasis-related death in 300 patients who received fluconazole (400 mg/d) or placebo for 75 days after BMT at the Fred Hutchinson Cancer Research Center. Patients in both treatment arms were compared for survival, causes of death, and the incidence of invasive fungal infections early (less than 110 days) and late (more than 110 days) after BMT. After 8 years of follow-up, survival is significantly better in fluconazole recipients compared with placebo recipients (68 of 152 vs 41 of 148,P = .0001). The overall incidence of invasive candidiasis was increased in patients who received placebo compared with fluconazole (30 of 148 vs 4 of 152, P < .001). More patients who received placebo died with candidiasis early (13 of 148 vs 1 of 152, P = .001) and late (8 of 96 vs 1 of 121,P = .0068) after BMT. The incidence of severe GVHD involving the gut was higher in patients who did not receive fluconazole (20 of 143 vs 8 of 145, P = .02), and fewer patients who received fluconazole died with this complication. Thus, administration of fluconazole (400 mg/d) for 75 days after BMT appears to be associated with decreased gut GVHD, a persistent protection against disseminated candidal infections and candidiasis-related death, resulting in an overall survival benefit in allogeneic BMT recipients.

Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial

Blood ◽  
2000 ◽  
Vol 96 (6) ◽  
pp. 2055-2061 ◽  
Author(s):  
Kieren A. Marr ◽  
Kristy Seidel ◽  
Monica A. Slavin ◽  
Raleigh A. Bowden ◽  
H. Gary Schoch ◽  
...  
Keyword(s):  
Invasive Candidiasis ◽  
Fungal Infections ◽  
Controlled Trial ◽  
Marrow Transplant ◽  
Blood And Marrow Transplant ◽  
Long Term Follow Up ◽  
Fluconazole Prophylaxis ◽  
Overall Survival Benefit

Abstract Two randomized, placebo-controlled trials previously showed that fluconazole (400 mg/d) administered prophylactically decreases the incidence of candidiasis in blood and marrow transplant (BMT) recipients. However, there exists conflicting data regarding the optimal duration of fluconazole administration, specifically whether prophylaxis through acute graft-versus-host disease (GVHD) results in improved survival in allograft recipients. Reported here are the results of long-term follow-up and a detailed analysis of invasive candidiasis and candidiasis-related death in 300 patients who received fluconazole (400 mg/d) or placebo for 75 days after BMT at the Fred Hutchinson Cancer Research Center. Patients in both treatment arms were compared for survival, causes of death, and the incidence of invasive fungal infections early (less than 110 days) and late (more than 110 days) after BMT. After 8 years of follow-up, survival is significantly better in fluconazole recipients compared with placebo recipients (68 of 152 vs 41 of 148,P = .0001). The overall incidence of invasive candidiasis was increased in patients who received placebo compared with fluconazole (30 of 148 vs 4 of 152, P &lt; .001). More patients who received placebo died with candidiasis early (13 of 148 vs 1 of 152, P = .001) and late (8 of 96 vs 1 of 121,P = .0068) after BMT. The incidence of severe GVHD involving the gut was higher in patients who did not receive fluconazole (20 of 143 vs 8 of 145, P = .02), and fewer patients who received fluconazole died with this complication. Thus, administration of fluconazole (400 mg/d) for 75 days after BMT appears to be associated with decreased gut GVHD, a persistent protection against disseminated candidal infections and candidiasis-related death, resulting in an overall survival benefit in allogeneic BMT recipients.

scholarly journals Best Practices for Medical Photography in Blood and Marrow Transplant (BMT) Long-Term Follow-up (LTFU) Telemedicine

2019 ◽  
Vol 25 (3) ◽  
pp. S426-S427
Author(s):  
Denae Davis ◽  
Larissa Murphy ◽  
Rose Rivett ◽  
Claudine Schneider ◽  
Mihkai Wickline
Keyword(s):  
Best Practices ◽  
Marrow Transplant ◽  
Blood And Marrow Transplant ◽  
Long Term Follow Up ◽  
Medical Photography

The autologous blood and marrow transplant long-term follow-up clinic: a model of care for following and treating survivors of autotransplant

2002 ◽  
Vol 10 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Aaron D. Schimmer ◽  
George Dranitsaris ◽  
Val Ali ◽  
Margaret Falconer ◽  
Armand Keating
Keyword(s):  
Autologous Blood ◽  
Marrow Transplant ◽  
Model Of Care ◽  
Blood And Marrow Transplant ◽  
Long Term Follow Up

scholarly journals Dosing 225Ac-DOTATOC in patients with somatostatin-receptor-positive solid tumors: 5-year follow-up of hematological and renal toxicity

2021 ◽  
Author(s):  
Clemens Kratochwil ◽  
Leonidas Apostolidis ◽  
Hendrik Rathke ◽  
Christos Apostolidis ◽  
Felix Bicu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Toxicity ◽  
Somatostatin Receptor ◽  
Dose Effect ◽  
Cancer Center ◽  
Hematological Toxicity ◽  
Starting Point ◽  
Long Term Follow Up

Abstract Purpose The aim of this retrospective analysis is to estimate the most appropriate single cycle and cumulative doses of 225Ac-DOTATOC in patients treated for somatostatin-receptor-expressing cancers. Methods 225Ac-DOTATOC was administered to thirty-nine patients with various somatostatin-receptor-positive tumors. Baseline and follow-up 68Ga-DOTATOC PET/CT, lab tests, and renal scintigraphy were obtained. Patients received long-term follow-up either at the local cancer center or in close collaboration with external oncologists. Acute and chronic hematological toxicity was evaluated quantitatively over time. Long-term follow-up of creatinine was used to approximate the annual loss of estimated GFR (eGFR). Results Dose-dependent acute hematological toxicity was seen at single doses above 40 MBq or repeated doses greater than approximately 20 MBq 225Ac-DOTATOC at 4 month intervals. Treatment-related kidney failure occurred in 2 patients after a delay of >4 years but was independent of administered radioactivity, and other clinical risk factors were important contributors to renal decline. In general, the annual decline of eGFR among patients did not follow a clear dose-effect relationship even in patients with previous β-therapy. An average eGFR-loss of 8.4ml/min (9.9%) per year was observed which is similar to the experience with β-therapy studies. Conclusion Treatment activities of approx. 20 MBq per cycle (4 monthly repetition) and cumulative doses up to 60–80 MBq generally avoided both acute and chronic grade 3/4 hematotoxicity in patients with advanced stage malignancies. Chronic renal toxicity was observed at these doses, but pre-existing renal risk factors were important co-factors. These data represent a starting point for additional research to more precisely define safety thresholds of 225Ac-DOTATOC.

scholarly journals Multiple Myeloma in Adolescent and Young Adults: A SEER and CIBMTR Analysis

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 12-13
Author(s):  
Steven J Gibson ◽  
Jennifer A Thornton ◽  
Christin B DeStefano
Keyword(s):  
Multiple Myeloma ◽  
Young Adults ◽  
Medical Center ◽  
The United States ◽  
Marrow Transplant ◽  
Cell Transplant ◽  
Blood And Marrow Transplant ◽  
Race Ethnicity

Background Multiple myeloma (MM) is a disease of the elderly, with less than 3% of cases diagnosed in adolescents and young adults (AYA). Data on demographics, use of autologous stem cell transplant (ASCT), second primary malignancies (SPMs) and survival are scant to non-existent in the AYA MM population. To our knowledge, this study is the first to better understand characteristics and survival trends of this unique population. Methods The Surveillance, Epidemiology, and End Results (SEER)-18 and Center for International Blood and Marrow Transplant Research (CIBMTR) datasets were utilized. Inclusion criteria were patients younger than 40 years old diagnosed with MM (ICD-O code 9732/3) between 2000-2017 (SEER) and 2008-2018 (CIBMTR). Variables assessed included age (&lt;30 vs. 30-39), gender, income (&lt;65K vs. ≥65K), race/ethnicity, place of residence (metropolitan vs. non-metropolitan), and year diagnosed (2000-2005 vs. 2006-2011 vs. 2012-2017). Incident SPMs were characterized as standardized incidence ratios (SIR). Analyses were conducted with STATA and data were censored at time of death or loss to follow up. Kaplan-Meier curves were generated for myeloma-specific survival (MSS). Individual variables were compared via log rank tests and Cox proportional hazard regression models. Model fit was assessed with Akaike's information criterion and Snell residuals. Assumptions of the Cox proportional hazards model were evaluated with log-time. Results There were 1,087 and 1,142 patients meeting criteria in SEER and CIBMTR, respectively. Median MSS was 181 months (15 years). The most common causes of death were MM (76%), SPMs (5.5%), and infection (3.6%). Statistically significant incident SPMs were lung cancers (SIR 4.94, p&lt;0.05), non-Hodgkin lymphoma (NHL) (SIR 5.28, p&lt;0.05), and acute myeloid leukemia (AML) (SIR 14.62, p&lt;0.05). Year of diagnosis strongly influenced survival. Compared to those diagnosed in 2000-2005, there was a 36% reduction in the risk of death among those diagnosed 2006-2011 (HR 0.64, 95% CI 0.49-0.82, p=0.001), and a 61% reduction among those diagnosed 2012-2017 (HR 0.39, 95% CI 0.26-0.58, p&lt;0.001). Race/ethnicity, gender, and age did not impact MSS. Among the AYA MM patients who received ASCT, notably 26% had a hematopoietic cell transplant comorbidity index (HCT-CI) of ≥ 3, nearly all received melphalan conditioning, and 80% received ASCT within the first year of diagnosis. One and four-year post-ASCT survival were 96% and 81%, respectively. Discussion To our knowledge, this is the first study assessing MM trends in the AYA population. Despite AYAs being underrepresented in MM clinical trials, the dramatic improvement in survival over time reflects efficacy of new drug approvals in this young population. It is also interesting that racial and socioeconomic disparities which are pervasive in the older adult MM population were not demonstrated in AYAs. AYA patients died from SPMs at rates similar to the adult MM population (3-6%), and notable incident SPMs in the AYA population were lung cancer, NHL, and AML. Also noteworthy was the high number of AYA MM patients who underwent up-front ASCT, which was nearly the same number of patients from the SEER dataset over half the amount of time. Since AYA MM patients have been underrepresented in trials utilizing ASCT, a survival benefit of ASCT in this population has not been demonstrated in the era of novel therapies. Further, given possible underlying genetic predisposition in AYA MM patients, long-term post-ASCT follow up is needed to better understand long-term toxicities including risk of hematological SPMs. Disclosures The findings and opinions contained herein are those of the authors and do not represent the views/opinions of the United States Air Force, Walter Reed National Military Medical Center, David Grant Medical Center, Department of Defense, or the Center for International Blood and Marrow Transplant Research (CIBMTR). Disclosures No relevant conflicts of interest to declare.

Failure pattern implications following external beam irradiation of prostate cancer: long-term follow-up and indications of cure. Alexandra L. Hanlon, Ph.D.,a,b Gerald E. Hanks, M.D.,b Departments of aRadiation Oncology and bBiostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA.Clinical utility of the percentage of positive prostate biopsies in defining biochemical outcome after radical prostatectomy for patients with clinically localized prostate cancer. Anthony V. D'Amico, Richard Whittington, S. Bruce Malkowicz, Delray Schultz, Julia Fondurulia, Ming-Hui Chen, John E. Tomaszewski, Andrew A. Renshaw, Alan Wein, and Jerome P. Richie, Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02215, USA.Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Prostate Cancer Trialists' Collaborative Group.Implications of stage-specific survival rates in assessing recent declines in prostate cancer mortality rates. Robert E. Tarone, Kenneth C. Chu, and Otis W. Brawley, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

2001 ◽  
Vol 6 (3) ◽  
pp. 123-124
Author(s):  
P Carroll
Keyword(s):  
Prostate Cancer ◽  
Survival Rates ◽  
Cancer Center ◽  
Beam Irradiation ◽  
External Beam Irradiation ◽  
Prostate Biopsies ◽  
Long Term Follow Up ◽  
Joint Center
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