scholarly journals A Modified Intensive Strategy to Prevent CMV Disease in Seropositive Umbilical Cord Blood Transplant Recipients

2018 ◽  
Vol 24 (3) ◽  
pp. S100-S101 ◽  
Author(s):  
Joshua A. Hill ◽  
Steven A. Pergam ◽  
Emily Cox ◽  
Hu Xie ◽  
Wendy M. Leisenring ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Transplant Recipients ◽  
Cord Blood Transplant ◽  
Cmv Disease

scholarly journals Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients

Blood ◽  
2011 ◽  
Vol 118 (20) ◽  
pp. 5689-5696 ◽  
Author(s):  
Filippo Milano ◽  
Steven A. Pergam ◽  
Hu Xie ◽  
Wendy M. Leisenring ◽  
Jonathan A. Gutman ◽  
...  
Keyword(s):  
High Risk ◽  
Confidence Interval ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Interquartile Range ◽  
Historical Cohort ◽  
Cord Blood Transplant ◽  
Cmv Disease ◽  
Cmv Reactivation

AbstractSeropositive umbilical cord blood transplant (UCBT) recipients are at increased risk for CMV complications. To reduce CMV complications, we adopted an intensive strategy that consisted of ganciclovir administered before transplantation (5 mg/kg intravenously daily from day −8 to day −2), high-dose acyclovir (2 g, 3 times daily) after transplanta-tion, and biweekly monitoring with a serum CMV PCR for preemptive therapy. Hazard rates and cumulative incidence of CMV complications along with days treated were compared in high-risk CMV-seropositive UCBT recipients who received the intensive strategy and a historical cohort who received a standard strategy. Of 72 seropositive patients, 29 (40%) received standard prophylaxis and 43 (60%) the new intensive approach. The hazard rate (HR) for CMV reactivation was lower for patients receiving the intensive strategy (HR 0.27, 95% confidence interval 0.15-0.48; P < .001) and led to fewer cases of CMV disease by 1 year (HR 0.11, 95% confidence interval 0.02-0.53; P = .006). In patients who reactivated, the intensive strategy also led to fewer days on CMV-specific antiviral therapy (median 42% [interquartile range 21-63] vs 70% [interquartile range 54-83], P < .001). Use of an intensive CMV prevention strategy in high-risk CMVseropositive UCBT recipients results in a significant decrease in CMV reactivation and disease.

scholarly journals Influence of human leucocyte antigen disparity and graft lymphocytes on allogeneic engraftment and survival after umbilical cord blood transplant in adults

2007 ◽  
Vol 139 (3) ◽  
pp. 464-474 ◽  
Author(s):  
Willem J. Van Heeckeren ◽  
Laura R. Fanning ◽  
Howard J. Meyerson ◽  
Pingfu Fu ◽  
Hillard M. Lazarus ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Human Leucocyte Antigen ◽  
Cord Blood Transplant

scholarly journals Unrelated Umbilical Cord Blood Transplant for Diamond-Blackfan Anemia

2014 ◽  
Vol 20 (2) ◽  
pp. S177 ◽  
Author(s):  
Alicia McFarren ◽  
Kristin Page ◽  
Suhag Parikh ◽  
Paul L. Martin ◽  
Timothy A. Driscoll ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Diamond Blackfan Anemia ◽  
Cord Blood Transplant
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