scholarly journals Primary Plasma Cell Leukemia: Stem Cell Transplant in an Era of Novel Induction Drugs

2018 ◽  
Vol 24 (3) ◽  
pp. S260-S261 ◽  
Author(s):  
Lohith Gowda ◽  
Mithun Vinod Shah ◽  
Ifra Badar ◽  
Qaiser Bashir ◽  
Nina Shah ◽  
...  
Keyword(s):  
Stem Cell ◽  
Plasma Cell ◽  
Stem Cell Transplant ◽  
Plasma Cell Leukemia ◽  
Cell Transplant ◽  
Cell Leukemia ◽  
Leukemia Stem Cell ◽  
Primary Plasma Cell Leukemia

scholarly journals Primary plasma cell leukemia: autologous stem cell transplant in an era of novel induction drugs

2018 ◽  
Vol 54 (7) ◽  
pp. 1089-1093 ◽  
Author(s):  
Lohith Gowda ◽  
Mithun Shah ◽  
Ifra Badar ◽  
Qaiser Bashir ◽  
Nina Shah ◽  
...  
Keyword(s):  
Stem Cell ◽  
Plasma Cell ◽  
Stem Cell Transplant ◽  
Autologous Stem Cell Transplant ◽  
Plasma Cell Leukemia ◽  
Cell Transplant ◽  
Cell Leukemia ◽  
Primary Plasma Cell Leukemia

Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant

2010 ◽  
Vol 25 (4) ◽  
pp. 223-225 ◽  
Author(s):  
Consuelo Funes ◽  
Faustino Garcia-Candel ◽  
Maria Juliana Majado ◽  
Consuelo González-García ◽  
Agueda Bas ◽  
...  
Keyword(s):  
Stem Cell ◽  
Plasma Cell ◽  
Stem Cell Transplant ◽  
Splenic Rupture ◽  
Autologous Stem Cell Transplant ◽  
Plasma Cell Leukemia ◽  
Cell Transplant ◽  
Cell Leukemia

scholarly journals Primary plasma cell leukemia and autologous stem cell transplantation

Haematologica ◽  
2010 ◽  
Vol 95 (5) ◽  
pp. 804-809 ◽  
Author(s):  
M. B. Drake ◽  
S. Iacobelli ◽  
A. van Biezen ◽  
C. Morris ◽  
J. F. Apperley ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Plasma Cell ◽  
Plasma Cell Leukemia ◽  
Cell Leukemia ◽  
Primary Plasma Cell Leukemia

scholarly journals Management of Primary Plasma Cell Leukemia Remains Challenging Even in the Era of Novel Agents

2021 ◽  
Vol 14 ◽  
pp. 263485352199938
Author(s):  
Chakra P Chaulagain ◽  
Maria-Julia Diacovo ◽  
Amy Van ◽  
Felipe Martinez ◽  
Chieh-Lin Fu ◽  
...  
Keyword(s):  
Cell Count ◽  
Plasma Cell ◽  
Peripheral Blood ◽  
Pet Scan ◽  
Plasma Cell Leukemia ◽  
Novel Agents ◽  
Cell Transplant ◽  
Cell Leukemia ◽  
Hematopoietic Stem ◽  
Primary Plasma Cell Leukemia

Primary plasma cell leukemia (PCL) is a rare and aggressive variant of multiple myeloma (MM). PCL is characterized by peripheral blood involvement by malignant plasma cells and an aggressive clinical course leading to poor survival. There is considerable overlap between MM and PCL with respect to clinical, immunophenotypic, and cytogenetic features, but circulating plasma cell count exceeding 20% of peripheral blood leukocytes or an absolute plasma cell count of >2000/mm3 distinguishes it from MM. After initial stabilization and diagnosis confirmation, treatment of PCL in a fit patient typically includes induction combination chemotherapy containing novel agents typically, with proteasome inhibitors (such as bortezomib) and immunomodulatory drugs (eg, lenalidomide), followed by autologous hematopoietic stem cell transplant (HSCT) and multidrug maintenance therapy using novel agents post-HSCT. Long-term outcomes have improved employing this strategy but the prognosis for non-HSCT candidates remains poor and new approaches are needed for such PCL patients not eligible for HSCT. Here, we report a case of primary PCL, and a comprehensive and up to date review of the literature for diagnosis and management of PCL. We also present the findings of Positron Emission Tomography (PET) scan. Since PCL is often associated with extra-medulary disease, including PET scan at the time of staging and restaging may be a novel approach particularly to evaluate the extra-medullary disease sites.

scholarly journals Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Matilda Ong’ondi ◽  
Elizabeth Kagotho
Keyword(s):  
Plasma Cell ◽  
Plasma Cells ◽  
De Novo ◽  
White Blood Cells ◽  
Autologous Stem Cell Transplant ◽  
Plasma Cell Leukemia ◽  
Plasma Cell Dyscrasia ◽  
Cell Transplant ◽  
Cell Leukemia ◽  
Primary Plasma Cell Leukemia

Plasma Cell Leukemia (PCL) is a rare and aggressive form of plasma cell dyscrasia that can arise either de novo (primary plasma cell leukemia) or evolve from previously diagnosed and treated multiple myeloma (secondary PCL). We highlight three clinical cases with very different presentations as a reminder of this diagnosis. The cases also highlight the diversity and variability that cover a patient’s journey that is highly dependent on accessibility based on financial capability and social support. The clinical presentation is more aggressive due to the higher tumour burden and more proliferative tumor cells with cytopenias being profound and more organomegaly. The diagnosis is made based on at least 20% of total white blood cells being circulating plasma cells with a peripheral blood absolute plasma cell count of at least 2 × 109/l. Treatment with novel agents followed by autologous stem cell transplant in those who are transplant eligible leads to better outcomes.

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