scholarly journals GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation

2017 ◽  
Vol 23 (11) ◽  
pp. 1918-1924 ◽  
Author(s):  
Tiago Nava ◽  
Mohamed A. Rezgui ◽  
Chakradhara R.S. Uppugunduri ◽  
Patricia Huezo-Diaz Curtis ◽  
Yves Théoret ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Genetic Variants ◽  
Conditioning Regimen ◽  
Key Factors ◽  
Hematopoietic Stem

scholarly journals Perspectives on the co-treatment with GnRHa in female patients undergoing hematopoietic stem cell transplantation

2017 ◽  
Vol 6 (8) ◽  
pp. R162-R170 ◽  
Author(s):  
Luminita Nicoleta Cima ◽  
Anca Colita ◽  
Simona Fica
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Randomized Clinical Trials ◽  
Conditioning Regimen ◽  
High Dose ◽  
Hematopoietic Stem ◽  
Gonadal Dysfunction

Outcomes after hematopoietic stem cell transplantation (HSCT) for patients with both malignant and nonmalignant diseases have improved significantly in recent years. However, the endocrine system is highly susceptible to damage by the high-dose chemotherapy and/or irradiation used in the conditioning regimen before HSCT. Ovarian failure and subsequent infertility are frequent complications that long-term HSCT survivors and their partners face with a negative impact on their QoL. Several meta-analyses of randomized clinical trials showed that gonadotropin-releasing hormone agonist (GnRHa) administration in advance of starting standard chemotherapy decreases the risk of gonadal dysfunction and infertility in cancer patients, but GnRHa use for ovarian protection in HSCT patients is not fully determined. In this review, we are discussing the potential preservation of ovarian function and fertility in pubertal girls/premenopausal women who undergo HSCT using GnRHa in parallel with conditioning chemotherapy, focusing on the current data available and making some special remarks regarding the use of GnRHa.

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