scholarly journals Commentary: Role of Mesenchymal Stromal Cell–Mediated Crosstalk with Macrophages in Graft-versus-Host Disease and Tissue Repair

2017 ◽  
Vol 23 (6) ◽  
pp. 861-862 ◽  
Author(s):  
Lindsay C. Davies ◽  
Erik Boberg ◽  
Katarina Le Blanc
Keyword(s):  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Tissue Repair ◽  
Stromal Cell ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Tissue immune profiles supporting response to mesenchymal stromal cell therapy in acute graft-versus-host disease—a gut feeling

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Caroline Gavin ◽  
Erik Boberg ◽  
Lena Von Bahr ◽  
Matteo Bottai ◽  
Anton Törnqvist Andrén ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Immune Cell ◽  
Therapeutic Potential ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Cell Profile ◽  
Acute Graft

AbstractAcute graft-versus-host disease (aGvHD), post-allogeneic hematopoietic stem cell transplantation, is associated with high mortality rates in patients not responding to standard line care with steroids. Adoptive mesenchymal stromal cell (MSC) therapy has been established in some countries as a second-line treatment.Limitations in our understanding as to MSC mode of action and what segregates patient responders from non-responders to MSC therapy remain. The principal aim of this study was to evaluate the immune cell profile in gut biopsies of patients diagnosed with aGvHD and establish differences in baseline cellular composition between responders and non-responders to subsequent MSC therapy.Our findings indicate that a pro-inflammatory immune profile within the gut at the point of MSC treatment may impede their therapeutic potential. These findings support the need for further validation in a larger cohort of patients and the development of improved biomarkers in predicting responsiveness to MSC therapy.

scholarly journals Clinical Translation of Mesenchymal Stromal Cell Therapy for Graft Versus Host Disease

2019 ◽  
Vol 7 ◽  
Author(s):  
Juliana A. P. Godoy ◽  
Raquel M. A. Paiva ◽  
Aline M. Souza ◽  
Andrea T. Kondo ◽  
Jose M. Kutner ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Clinical Translation ◽  
Host Disease ◽  
Graft Versus Host

Functional dosing of mesenchymal stromal cell-derived extracellular vesicles for the prevention of acute graft-versus-host-disease

Stem Cells ◽  
2020 ◽  
Vol 38 (5) ◽  
pp. 698-711 ◽  
Author(s):  
Giada Dal Collo ◽  
Annalisa Adamo ◽  
Alessandro Gatti ◽  
Edoardo Tamellini ◽  
Riccardo Bazzoni ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

Application of a mesenchymal stromal cell-derived two-factor cocktail in graft versus host disease therapy

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S36
Author(s):  
X. Fan ◽  
D. Guo ◽  
C. Yap ◽  
A. Cheung ◽  
Z. Poon ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Host Disease ◽  
Graft Versus Host ◽  
Disease Therapy
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