scholarly journals Pericardial Effusion Following Hematopoietic Cell Transplantation in Children and Young Adults Is Associated with Increased Risk of Mortality

2017 ◽  
Vol 23 (7) ◽  
pp. 1165-1169 ◽  
Author(s):  
Kelly Cox ◽  
Rajesh Punn ◽  
Elizabeth Weiskopf ◽  
Benjamin A. Pinsky ◽  
Sandhya Kharbanda
Keyword(s):  
Young Adults ◽  
Pericardial Effusion ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Children And Young Adults

scholarly journals Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia

2019 ◽  
Vol 25 (2) ◽  
pp. 301-306 ◽  
Author(s):  
Troy C. Lund ◽  
Kwang Woo Ahn ◽  
Heather R. Tecca ◽  
Megan V. Hilgers ◽  
Hisham Abdel-Azim ◽  
...  
Keyword(s):  
Young Adults ◽  
Acute Leukemia ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Children And Young Adults

Limits of HLA mismatching in unrelated hematopoietic cell transplantation

Blood ◽  
2004 ◽  
Vol 104 (9) ◽  
pp. 2976-2980 ◽  
Author(s):  
Effie W. Petersdorf ◽  
Claudio Anasetti ◽  
Paul J. Martin ◽  
Ted Gooley ◽  
Jerald Radich ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Myeloid Leukemia ◽  
Hematopoietic Cell Transplantation ◽  
Early Stage ◽  
Hematopoietic Cell ◽  
Hla Matching ◽  
Advanced Malignancy ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Matched Donor

Abstract HLA matching between the donor and recipient improves the success of unrelated hematopoietic cell transplantation (HCT). Matched donors are available for only a minority of patients. Further information is needed to evaluate the limits of HLA mismatching. We examined the association of mortality with HLA-A, -B, -C, -DRB1, and -DQB1 mismatching in 948 patients who received a T-replete unrelated HCT for treatment of a marrow disorder. A single HLA allele or antigen mismatch was associated with increased mortality among patients with chronic myeloid leukemia (CML) within 2 years after diagnosis compared to patients with no HLA mismatch, but not among those with more advanced malignancy. In particular, a single HLA-C mismatch conferred increased risk of mortality compared to matches. There was a suggestion for increased mortality with multiple mismatches involving HLA-DQB1 compared to multiple mismatches not involving HLA-DQB1. Donors with a single HLA allele or antigen mismatch may be used for HCT when a fully matched donor is not available for patients with diseases that do not permit time for a lengthy search. Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches.

scholarly journals HLA-DRB3/4/5 mismatches are associated with increased risk of acute GVHD in 10/10 matched unrelated donor hematopoietic cell transplantation

2018 ◽  
Vol 93 (8) ◽  
pp. 994-1001
Author(s):  
Stéphanie Ducreux ◽  
Valérie Dubois ◽  
Kahina Amokrane ◽  
Ibrahim Yakoub-Agha ◽  
Myriam Labalette ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Acute Gvhd ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Unrelated Donor ◽  
Matched Unrelated Donor ◽  
Increased Risk
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