scholarly journals Matching at Human Leukocyte Antigen-C Improved the Outcomes after Double Umbilical Cord Blood Transplantation for Recipients of Two to Four of Six Human Leukocyte Antigen–Matched Grafts

2017 ◽  
Vol 23 (1) ◽  
pp. 126-133 ◽  
Author(s):  
Claudio G. Brunstein ◽  
Corey S. Cutler ◽  
Todd E. DeFor ◽  
Haesook Kim ◽  
Nelli Bejanyan ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Human Leukocyte ◽  
Umbilical Cord Blood Transplantation ◽  
Leukocyte Antigen ◽  
Blood Transplantation

scholarly journals Umbilical cord blood transplantation: the first 25 years and beyond

Blood ◽  
2013 ◽  
Vol 122 (4) ◽  
pp. 491-498 ◽  
Author(s):  
Karen K. Ballen ◽  
Eliane Gluckman ◽  
Hal E. Broxmeyer
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Cell Transplantation ◽  
Cord Blood Transplantation ◽  
Human Leukocyte ◽  
Umbilical Cord Blood Transplantation ◽  
Hematopoietic Stem ◽  
Cell Dose ◽  
Blood Transplantation

Abstract Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation. Initially, umbilical cord blood transplantation was limited to children, given the low cell dose infused. Both related and unrelated cord blood transplants have been performed with high rates of success for a variety of hematologic disorders and metabolic storage diseases in the pediatric setting. The results for adult umbilical cord blood transplantation have improved, with greater emphasis on cord blood units of sufficient cell dose and human leukocyte antigen match and with the use of double umbilical cord blood units and improved supportive care techniques. Cord blood expansion trials have recently shown improvement in time to engraftment. Umbilical cord blood is being compared with other graft sources in both retrospective and prospective trials. The growth of the field over the last 25 years and the plans for future exploration are discussed.

Intrabone infusion for allogeneic umbilical cord blood transplantation in children

2021 ◽  
Author(s):  
Stephanie Vairy ◽  
Isabelle Louis ◽  
Marie-France Vachon ◽  
Johanne Richer ◽  
Pierre Teira ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Blood Transplantation

scholarly journals Human Leukocyte Antigen and Red Blood Cells Impact Umbilical Cord Blood CD34+ Cell Viability after Thawing

2019 ◽  
Vol 20 (19) ◽  
pp. 4875 ◽  
Author(s):  
Vanegas ◽  
Galindo ◽  
Páez-Gutiérrez ◽  
González-Acero ◽  
Medina-Valderrama ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Cell Viability ◽  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Leukocyte Antigen

Hematopoietic progenitor cell (HPC) transplantation is a treatment option for malignant and nonmalignant diseases. Umbilical cord blood (UCB) is an important HPC source, mainly for pediatric patients. It has been demonstrated that human leukocyte antigen (HLA) matching and cell dose are the most important features impacting clinical outcomes. However, UCB matching is performed using low resolution HLA typing and it has been demonstrated that the unnoticed mismatches negatively impact the transplant. Since we found differences in CD34+ viability after thawing of UCB units matched for two different patients (p = 0.05), we presumed a possible association between CD34+ cell viability and HLA. We performed a multivariate linear model (n = 67), comprising pre-cryopreservation variables and high resolution HLA genotypes separately. We found that pre-cryopreservation red blood cells (RBC), granulocytes, and viable CD34+ cell count significantly impacted CD34+ viability after thawing, along with HLA-B or -C (R2 = 0.95, p = 0.01; R2 = 0.56, p = 0.007, respectively). Although HLA-B*40:02 may have a negative impact on CD34+ cell viability, RBC depletion significantly improves it.

Primary research on unrelated double umbilical cord blood transplantation and implantation kinetics

Hematology ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 253-259 ◽  
Author(s):  
Kaidi Song ◽  
Zimin Sun ◽  
Huilan Liu ◽  
Liangquan Geng ◽  
Kaiyang Ding ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cord Blood Transplantation ◽  
Umbilical Cord Blood Transplantation ◽  
Primary Research ◽  
Blood Transplantation
Sign in / Sign up

Export Citation Format

Share Document