scholarly journals Second Cancer Risk and Late Mortality in Adult Australians Receiving Allogeneic Hematopoietic Stem Cell Transplantation: A Population-Based Cohort Study

2016 ◽  
Vol 22 (5) ◽  
pp. 949-956 ◽  
Author(s):  
Claire M. Vajdic ◽  
Eleni Mayson ◽  
Anthony J. Dodds ◽  
Tracey O'Brien ◽  
Leonie Wilcox ◽  
...  
Keyword(s):  
Cohort Study ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Cancer Risk ◽  
Stem Cell Transplantation ◽  
Population Based ◽  
Second Cancer ◽  
Hematopoietic Stem ◽  
Late Mortality ◽  
Second Cancer Risk

scholarly journals Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sheng-Min Wang ◽  
Sung-Soo Park ◽  
Si-Hyun Park ◽  
Nak-Young Kim ◽  
Dong Woo Kang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cohort Study ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Depression Group

Abstract Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214)] who received allo-HSCT from 2002 to 2018 in South Korea, analyzed risk of pre-transplant depression in OS of allo-HSCT. Subjects were followed from the day they received allo-HSCT, to occurrence of death, or last follow-up day (December 31, 2018). Median age at allo-HSCT for depression and non-depression groups were 50 and 45 (p < 0.0001), respectively. Two groups also differed in rate of females (depression group, 55.8%; non-depression group, 43.8%; p < 0.0001) and leukemia (depression group, 61.4%; non-depression group, 49.7%; p < 0.0001). After a median follow-up of 29.1 months, 5-year OS rate was 63.1%. Cox proportional-hazard regression evaluated an adjusted risk of post-transplant mortality related to depression: OS decreased sequentially from no depression (adjusted hazard ratio [aHR] = 1) to pre-transplant depression only (aHR = 1.167, CI: 1.007–1.352, p = 0.04), and to having both depression and anxiety disorder (aHR = 1.202, CI: 1.038–1.393, p = 0.014) groups. Pre-transplant anxiety (anxiety only) did not have significant influence in OS. Additional medical and psychiatric care might be necessary in patients who experienced depression, especially with anxiety, before allo-HSCT.

scholarly journals Second cancer risk in adults receiving autologous haematopoietic SCT for cancer: a population-based cohort study

2014 ◽  
Vol 49 (5) ◽  
pp. 691-698 ◽  
Author(s):  
I A Bilmon ◽  
◽  
L J Ashton ◽  
R E Le Marsney ◽  
A J Dodds ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Second Cancer ◽  
Second Cancer Risk
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