scholarly journals Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0p in Chronic Graft-versus-Host Disease of the Lung

2015 ◽  
Vol 21 (6) ◽  
pp. 1127-1131 ◽  
Author(s):  
Sameem Abedin ◽  
Gregory A. Yanik ◽  
Thomas Braun ◽  
Attaphol Pawarode ◽  
John Magenau ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Predictive Value ◽  
Bronchiolitis Obliterans ◽  
Bronchiolitis Obliterans Syndrome ◽  
Host Disease ◽  
Graft Versus Host

Effect of Rituximab on Pulmonary Function in Bronchiolitis Obliterans Syndrome due to Graft-Versus-Host-Disease

Lung ◽  
2017 ◽  
Vol 195 (6) ◽  
pp. 781-788 ◽  
Author(s):  
Kyle R. Brownback ◽  
Laura A. Thomas ◽  
Joseph P. McGuirk ◽  
Siddhartha Ganguly ◽  
Christopher Streiler ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Graft Versus Host Disease ◽  
Bronchiolitis Obliterans ◽  
Bronchiolitis Obliterans Syndrome ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals A distinct glycerophospholipid metabolism signature of acute graft versus host disease with predictive value

JCI Insight ◽  
2019 ◽  
Vol 4 (16) ◽  
Author(s):  
Yue Liu ◽  
Aijie Huang ◽  
Qi Chen ◽  
Xiaofei Chen ◽  
Yang Fei ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Predictive Value ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

Ruxolitinib is an effective steroid sparing agent in bronchiolitis obliterans due to chronic graft-versus-host-disease

2019 ◽  
Vol 55 (6) ◽  
pp. 1194-1196 ◽  
Author(s):  
Christopher Streiler ◽  
Faizan Shaikh ◽  
Christian Davis ◽  
Sunil Abhyankar ◽  
Kyle R. Brownback
Keyword(s):  
Graft Versus Host Disease ◽  
Bronchiolitis Obliterans ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Sparing

scholarly journals Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

Blood ◽  
2019 ◽  
Vol 134 (3) ◽  
pp. 304-316 ◽  
Author(s):  
Geoffrey D. E. Cuvelier ◽  
Eneida R. Nemecek ◽  
Justin T. Wahlstrom ◽  
Carrie L. Kitko ◽  
Victor A. Lewis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Bronchiolitis Obliterans Syndrome ◽  
National Institutes Of Health ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Nih Consensus Criteria ◽  
Adjudication Committee

Abstract Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients <18 years of age. The objectives of this prospective multi-institution study were to determine: (1) whether the NIH-CC could be used to diagnose pediatric cGVHD and whether the criteria operationalize well in a multi-institution study; (2) the frequency of cGVHD and L-aGVHD in children using the NIH-CC; and (3) the clinical features and risk factors for cGVHD and L-aGVHD using the NIH-CC. Twenty-seven transplant centers enrolled 302 patients <18 years of age before conditioning and prospectively followed them for 1 year posttransplant for development of cGVHD. Centers justified their cGVHD diagnosis according to the NIH-CC using central review and a study adjudication committee. A total of 28.2% of reported cGVHD cases was reclassified, usually as L-aGVHD, following study committee review. Similar incidence of cGVHD and L-aGVHD was found (21% and 24.7%, respectively). The most common organs involved with diagnostic or distinctive manifestations of cGVHD in children include the mouth, skin, eyes, and lungs. Importantly, the 2014 NIH-CC for bronchiolitis obliterans syndrome perform poorly in children. Past acute GVHD and peripheral blood grafts are major risk factors for cGVHD and L-aGVHD, with recipients ≥12 years of age being at risk for cGVHD. Applying the NIH-CC in pediatrics is feasible and reliable; however, further refinement of the criteria specifically for children is needed.

Oral and ophthalmic pathology of graft versus host disease in man: Predictive value of the lip biopsy

1981 ◽  
Vol 12 (11) ◽  
pp. 1022-1030 ◽  
Author(s):  
George E. Sale ◽  
Howard M. Shulman ◽  
Mark M. Schubert ◽  
Keith M. Sullivan ◽  
Kenneth J. Kopecky ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Predictive Value ◽  
Host Disease ◽  
Graft Versus Host ◽  
Ophthalmic Pathology ◽  
Lip Biopsy

scholarly journals CD19+CD21low B cells and patients at risk for NIH-defined chronic graft-versus-host disease with bronchiolitis obliterans syndrome

Blood ◽  
2013 ◽  
Vol 121 (10) ◽  
pp. 1886-1895 ◽  
Author(s):  
Zoya Kuzmina ◽  
Katharina Krenn ◽  
Ventzislav Petkov ◽  
Ulrike Körmöczi ◽  
Roman Weigl ◽  
...  
Keyword(s):  
At Risk ◽  
B Cells ◽  
B Cell ◽  
Graft Versus Host Disease ◽  
Bronchiolitis Obliterans ◽  
Bronchiolitis Obliterans Syndrome ◽  
Cell Subpopulation ◽  
Graft Versus Host ◽  
Key Points ◽  
Patients At Risk

Key Points B-cell subpopulation as biomarker for NIH-defined BOS.

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