scholarly journals Expansion and Homing of Umbilical Cord Blood Hematopoietic Stem and Progenitor Cells for Clinical Transplantation

2015 ◽  
Vol 21 (6) ◽  
pp. 1008-1019 ◽  
Author(s):  
Sudipto Bari ◽  
Kevin Kwee Hong Seah ◽  
Zhiyong Poon ◽  
Alice Man Sze Cheung ◽  
Xiubo Fan ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Stem ◽  
Clinical Transplantation ◽  
Stem And Progenitor Cells

Analysis and cryopreservation of hematopoietic stem and progenitor cells from umbilical cord blood

Cytotherapy ◽  
2006 ◽  
Vol 8 (3) ◽  
pp. 265-276 ◽  
Author(s):  
T.P.H. Meyer ◽  
B. Hofmann ◽  
J. Zaisserer ◽  
V.R. Jacobs ◽  
B. Fuchs ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells

Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells from Umbilical Cord Blood

Acta Naturae ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 6-16 ◽  
Author(s):  
E. V. Sotnezova ◽  
E. R. Andreeva ◽  
A. I. Grigoriev ◽  
L. B. Buravkova
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Ex Vivo ◽  
Ex Vivo Expansion ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells ◽  
Cord Blood Cells

Transplantation of umbilical cord blood cells is currently widely used in modern cell therapy. However, the limited number of hematopoietic stem and progenitor cells (HSPCs) and prolonged time of recovery after the transplantation are significant limitations in the use of cord blood. Ex vivo expansion with various cytokine combinations is one of the most common approaches for increasing the number of HSPCs from one cord blood unit. In addition, there are protocols that enable ex vivo amplification of cord blood cells based on native hematopoietic microenvironmental cues, including stromal components and the tissue-relevant oxygen level. The newest techniques for ex vivo expansion of HSPCs are based on data from the elucidation of the molecular mechanisms governing the hematopoietic niche function. Application of these methods has provided an improvement of several important clinical outcomes. Alternative methods of cord blood transplantation enhancement based on optimization of HPSC homing and engraftment in patient tissues have also been successful. The goal of the present review is to analyze recent methodological approaches to cord blood HSPC ex vivo amplification.

Preservation of Hematopoietic Stem and Progenitor Cells from Umbilical Cord Blood Stored in a Surface Derivatized with Polymer Nanosegments

2008 ◽  
Vol 9 (2) ◽  
pp. 634-639 ◽  
Author(s):  
Akon Higuchi ◽  
Wen-Yih Chen ◽  
Taro Yamamoto ◽  
Yumiko Gomei ◽  
Hisashi Fukushima ◽  
...  
Keyword(s):  
Cord Blood ◽  
Progenitor Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells
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