scholarly journals Older Survivors of Allogeneic Hematopoietic Cell Transplantation (HCT) with Chronic Graft Vs. Host Disease (cGvHD) Demonstrate Higher Risk of Frailty As Compared with Autologous HCT Recipients: A Report from the Bone Marrow Transplant Survivor Study-2

2015 ◽  
Vol 21 (2) ◽  
pp. S72-S73 ◽  
Author(s):  
Mukta Arora ◽  
Canlan Sun ◽  
Kirsten Ness ◽  
Jennifer Berano Teh ◽  
Amy Schad ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Transplantation ◽  
Bone Marrow Transplant ◽  
Hematopoietic Cell Transplantation ◽  
Marrow Transplant ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Autologous Hct

scholarly journals Adverse psychological outcomes in long-term survivors of hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study (BMTSS)

Blood ◽  
2011 ◽  
Vol 118 (17) ◽  
pp. 4723-4731 ◽  
Author(s):  
Can-Lan Sun ◽  
Liton Francisco ◽  
K. Scott Baker ◽  
Daniel J. Weisdorf ◽  
Stephen J. Forman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Transplantation ◽  
Bone Marrow Transplant ◽  
Psychological Health ◽  
Hematopoietic Cell Transplantation ◽  
Marrow Transplant ◽  
Psychological Outcomes ◽  
Hematopoietic Cell ◽  
Somatic Distress

Abstract Little information exists regarding long-term psychological health of hematopoietic cell transplantation (HCT) survivors. Using resources offered by the Bone Marrow Transplant Survivor Study (BMTSS), we evaluated adverse psychological outcomes in 1065 long-term HCT survivors and a healthy comparison group composed of siblings. Psychological health status was evaluated using the Brief Symptom Inventory-18. Twenty-two percent of the HCT survivors reported adverse psychological outcomes, compared with 8% of the siblings. Exposure to prednisone was associated with psychological distress across all domains (anxiety, depression, and somatic distress). Fifteen percent of the HCT survivors reported somatic distress, representing an almost 3-fold higher risk comparing to siblings. Among survivors, in addition to low annual household income and self-reported poor health, having severe/life-threatening conditions and presence of active chronic GVHD were associated with a 2-fold increased risk for somatic distress. Seven percent of the HCT survivors expressed suicidal ideation; patients with higher scores on depression subscale were most vulnerable. This study demonstrates that somatic distress is the biggest challenge faced by survivors long after HCT. These results identify vulnerable subpopulations and provide patients, families, and healthcare providers with necessary information to plan for post-HCT needs many years after HCT.

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