scholarly journals The Effect of Cidofovir on Adenovirus Plasma DNA Levels in Stem Cell Transplantation Recipients without T Cell Reconstitution

2015 ◽  
Vol 21 (2) ◽  
pp. 293-299 ◽  
Author(s):  
Gertjan Lugthart ◽  
Marloes A. Oomen ◽  
Cornelia M. Jol-van der Zijde ◽  
Lynne M. Ball ◽  
Dorine Bresters ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Plasma Dna ◽  
T Cell Reconstitution

scholarly journals Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

2018 ◽  
Vol 2 (4) ◽  
pp. 428-432 ◽  
Author(s):  
Coco de Koning ◽  
Rick Admiraal ◽  
Stefan Nierkens ◽  
Jaap Jan Boelens
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Hematopoietic Stem ◽  
T Cell Reconstitution ◽  
Key Points

Key PointsOnly high HHV6 viremia (>105 copies/mL) affects late but not early T-cell reconstitution after HCT. Antivirals improve T-cell reconstitution probability in the context of HHV6 viremia after HCT.

Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype

Blood ◽  
2007 ◽  
Vol 109 (10) ◽  
pp. 4575-4581 ◽  
Author(s):  
Marina Cavazzana-Calvo ◽  
Frédérique Carlier ◽  
Françoise Le Deist ◽  
Estelle Morillon ◽  
Pierre Taupin ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Cell Receptor ◽  
Hematopoietic Stem ◽  
T Cell Reconstitution

Abstract We studied T-cell reconstitution in 31 primary T-cell–immunodeficient patients who had undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 patients, there was no evidence of myeloid chimerism because little or no myeloablation had been performed. Given this context, we sought factors associated with good long-term T-cell reconstitution. We found that all patients having undergone full myeloablation had donor myeloid cells and persistent thymopoiesis, as evidenced by the presence of naive T cells carrying T-cell receptor excision circles (TRECs). In 9 patients with host myeloid chimerism, sustained thymic output was also observed and appeared to be associated with γc deficiency. It is therefore possible that the complete absence of thymic progenitors characterizing this condition created a more favorable environment for thymic seeding by a population of early progenitor cells with the potential for self-renewal, thus enabling long-term (> 10 years) T-cell production.

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