Factors Predictive of Relapse of Acute Leukemia in Children after Allogeneic Hematopoietic Cell Transplantation

Nirali N. Shah; Michael J. Borowitz; Seth M. Steinberg; Nancy C. Robey; Christopher J. Gamper; Heather J. Symons; David M. Loeb; Alan S. Wayne; Allen R. Chen

doi:10.1016/j.bbmt.2014.03.028

Factors Predictive of Relapse of Acute Leukemia in Children after Allogeneic Hematopoietic Cell Transplantation

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2014.03.028 ◽

2014 ◽

Vol 20 (7) ◽

pp. 1033-1039 ◽

Cited By ~ 11

Author(s):

Nirali N. Shah ◽

Michael J. Borowitz ◽

Seth M. Steinberg ◽

Nancy C. Robey ◽

Christopher J. Gamper ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Leukemia In Children

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Effect of Donor Age and Donor Relatedness on Time to Allogeneic Hematopoietic Cell Transplantation in Acute Leukemia

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2018.07.022 ◽

2018 ◽

Vol 24 (12) ◽

pp. 2466-2470 ◽

Cited By ~ 3

Author(s):

Alissa Visram ◽

Joseph Aziz ◽

Adam Bryant ◽

Tinghua Zhang ◽

Carolina Cieniak ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Donor Age

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Second allogeneic hematopoietic cell transplantation enables long-term disease-free survival in relapsed acute leukemia

Annals of Hematology ◽

10.1007/s00277-018-3454-y ◽

2018 ◽

Vol 97 (12) ◽

pp. 2491-2500 ◽

Cited By ~ 12

Author(s):

Corina Schneidawind ◽

Volker Hagmaier ◽

Christoph Faul ◽

Lothar Kanz ◽

Wolfgang Bethge ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Disease Free Survival ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Free Survival ◽

Disease Free

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Bone marrow vs extramedullary relapse of acute leukemia after allogeneic hematopoietic cell transplantation: risk factors and clinical course

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1704223 ◽

2003 ◽

Vol 32 (8) ◽

pp. 835-842 ◽

Cited By ~ 71

Author(s):

K-H Lee ◽

J-H Lee ◽

S-J Choi ◽

J-H Lee ◽

S Kim ◽

...

Keyword(s):

Risk Factors ◽

Bone Marrow ◽

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Clinical Course ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Extramedullary Relapse

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Dose Escalation of Total Marrow Irradiation With Concurrent Chemotherapy in Patients With Advanced Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.03.033 ◽

2013 ◽

Vol 85 (1) ◽

pp. 148-156 ◽

Cited By ~ 43

Author(s):

Jeffrey Y.C. Wong ◽

Stephen Forman ◽

George Somlo ◽

Joseph Rosenthal ◽

An Liu ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Dose Escalation ◽

Hematopoietic Cell Transplantation ◽

Concurrent Chemotherapy ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Total Marrow Irradiation

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Outcomes of allogeneic hematopoietic cell transplantation in patients with biphenotypic acute leukemia

Annals of Hematology ◽

10.1007/s00277-015-2536-3 ◽

2015 ◽

Vol 95 (2) ◽

pp. 295-300 ◽

Cited By ~ 3

Author(s):

Jinichi Mori ◽

Ken Ishiyama ◽

Takuhiro Yamaguchi ◽

Junji Tanaka ◽

Naoyuki Uchida ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Biphenotypic Acute Leukemia

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Long-Term Survival and Late Effects Among 1-Year Survivors of Second Allogeneic Hematopoietic Cell Transplantation (2nd Allo HCT) for Relapsed Acute Leukemia and Myelodysplastic Syndrome: A Report from the Cibmtr

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2013.12.073 ◽

2014 ◽

Vol 20 (2) ◽

pp. S64

Author(s):

Christine Duncan ◽

Navneet S. Majhail ◽

Ruta Brazauskas ◽

Zhiwei Wang ◽

Jean-Yves Cahn ◽

...

Keyword(s):

Acute Leukemia ◽

Myelodysplastic Syndrome ◽

Cell Transplantation ◽

Late Effects ◽

Hematopoietic Cell Transplantation ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Term Survival ◽

Long Term Survival

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Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison Among Alternative Graft Sources

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2013.12.119 ◽

2014 ◽

Vol 20 (2) ◽

pp. S92

Author(s):

Karen K. Ballen ◽

Navneet S. Majhail ◽

Ruta Brazauskas ◽

Zhiwei Wang ◽

Mahmoud D. Aljurf ◽

...

Keyword(s):

Length Of Stay ◽

Acute Leukemia ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Hospital Length ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Hospital Length Of Stay

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High Alloreactivity of Low-Dose Prophylactic Donor Lymphocyte Infusion in Patients with Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation with an Alemtuzumab-Containing Conditioning Regimen

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2012.07.021 ◽

2013 ◽

Vol 19 (1) ◽

pp. 75-81 ◽

Cited By ~ 47

Author(s):

Maria Liga ◽

Evangelia Triantafyllou ◽

Maria Tiniakou ◽

Polyxeni Lambropoulou ◽

Marina Karakantza ◽

...

Keyword(s):

Acute Leukemia ◽

Cell Transplantation ◽

Low Dose ◽

Hematopoietic Cell Transplantation ◽

Conditioning Regimen ◽

Donor Lymphocyte Infusion ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation

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Changes in incidence and causes of non-relapse mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia/myelodysplastic syndrome: an analysis of the Japan Transplant Outcome Registry

Bone Marrow Transplantation ◽

10.1038/bmt.2012.172 ◽

2012 ◽

Vol 48 (4) ◽

pp. 529-536 ◽

Cited By ~ 40

Author(s):

S Kurosawa ◽

K Yakushijin ◽

T Yamaguchi ◽

Y Atsuta ◽

T Nagamura-Inoue ◽

...

Keyword(s):

Acute Leukemia ◽

Myelodysplastic Syndrome ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Transplant Outcome ◽

Outcome Registry

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How I treat measurable (minimal) residual disease in acute leukemia after allogeneic hematopoietic cell transplantation

Blood ◽

10.1182/blood.2019003566 ◽

2020 ◽

Vol 135 (19) ◽

pp. 1639-1649 ◽

Cited By ~ 5

Author(s):

Alexandros Spyridonidis

Keyword(s):

Acute Leukemia ◽

Minimal Residual Disease ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Residual Disease ◽

Hematopoietic Cell ◽

Allogeneic Hematopoietic Cell Transplantation ◽

Leukemia Relapse ◽

Minimal Residual

Abstract Although allogeneic hematopoietic cell transplantation (allo-HCT) is currently the standard curative treatment of acute leukemia, relapse remains unacceptably high. Measurable (minimal) residual disease (MRD) after allo-HCT may be used as a predictor of impending relapse and should be part of routine follow-up for transplanted patients. Patients with MRD may respond to therapies aiming to unleash or enhance the graft-versus-leukemia effect. However, evidence-based recommendations on how to best implement MRD testing and MRD-directed therapy after allo-HCT are lacking. Here, I describe our institutional approach to MRD monitoring for preemptive MRD-triggered intervention, using patient scenarios to illustrate the discussion.

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