scholarly journals Donor-Derived Natural Killer Cells Infused after Human Leukocyte Antigen–Haploidentical Hematopoietic Cell Transplantation: A Dose-Escalation Study

2014 ◽  
Vol 20 (5) ◽  
pp. 696-704 ◽  
Author(s):  
Inpyo Choi ◽  
Suk Ran Yoon ◽  
Soo-Yeon Park ◽  
Hanna Kim ◽  
Sol-Ji Jung ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Human Leukocyte Antigen ◽  
Natural Killer ◽  
Cell Transplantation ◽  
Dose Escalation ◽  
Hematopoietic Cell Transplantation ◽  
Human Leukocyte ◽  
Dose Escalation Study ◽  
Leukocyte Antigen ◽  
Haploidentical Hematopoietic Cell Transplantation

scholarly journals Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shoeib Moradi ◽  
Sanda Stankovic ◽  
Geraldine M. O’Connor ◽  
Phillip Pymm ◽  
Bruce J. MacLachlan ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Human Leukocyte Antigen ◽  
Nk Cells ◽  
Natural Killer ◽  
Crystal Structures ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Functional Differences ◽  
Molecular Bases

AbstractThe closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this variation being associated with differences in the onset and progression of some human diseases. However, the molecular bases underlying these associations remain unresolved. Here, we determined the crystal structures of KIR2DL2 and KIR2DL3 in complex with HLA-C*07:02 presenting a self-epitope. KIR2DL2 differed from KIR2DL3 in docking modality over HLA-C*07:02 that correlates with variabilty of recognition of HLA-C1 allotypes. Mutagenesis assays indicated differences in the mechanism of HLA-C1 allotype recognition by KIR2DL2 and KIR2DL3. Similarly, HLA-C1 allotypes differed markedly in their capacity to inhibit activation of primary NK cells. These functional differences derive, in part, from KIR2DS2 suggesting KIR2DL2 and KIR2DL3 binding geometries combine with other factors to distinguish HLA-C1 functional recognition.

scholarly journals Increased frequency of human leukocyte antigen–E inhibitory receptor CD94/NKG2A–expressing peritoneal natural killer cells in patients with endometriosis

2008 ◽  
Vol 89 (5) ◽  
pp. 1490-1496 ◽  
Author(s):  
Ricciarda Galandrini ◽  
Maria Grazia Porpora ◽  
Antonella Stoppacciaro ◽  
Federica Micucci ◽  
Cristina Capuano ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Human Leukocyte Antigen ◽  
Natural Killer ◽  
Human Leukocyte ◽  
Inhibitory Receptor ◽  
Killer Cells ◽  
Leukocyte Antigen

scholarly journals Human Leukocyte Antigen E Contributes to Protect Tumor Cells from Lysis by Natural Killer Cells

Neoplasia ◽  
2011 ◽  
Vol 13 (9) ◽  
pp. 822-IN14 ◽  
Author(s):  
Elisa Lo Monaco ◽  
Elisa Tremante ◽  
Cristina Cerboni ◽  
Elisa Melucci ◽  
Leonardo Sibilio ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Human Leukocyte Antigen ◽  
Natural Killer ◽  
Tumor Cells ◽  
Human Leukocyte ◽  
Killer Cells ◽  
Leukocyte Antigen
Sign in / Sign up

Export Citation Format

Share Document