scholarly journals Iron Overload in Allogeneic Stem Cell Transplantation Outcome: A Meta-Analysis

2014 ◽  
Vol 20 (2) ◽  
pp. S27-S28
Author(s):  
Philippe Armand ◽  
Haesook T. Kim ◽  
Johanna Virtanen ◽  
Maija Itälä-Remes ◽  
Navneet S. Majhail ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Iron Overload ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Meta Analysis

scholarly journals Prognostic Impact of Posttransplantation Iron Overload after Allogeneic Stem Cell Transplantation

2013 ◽  
Vol 19 (3) ◽  
pp. 440-444 ◽  
Author(s):  
Sara C. Meyer ◽  
Alix O’Meara ◽  
Andreas S. Buser ◽  
André Tichelli ◽  
Jakob R. Passweg ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Iron Overload ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Prognostic Impact

scholarly journals Gradually-Deteriorating Liver Function due to Iron Overload Over Four Years after Allogeneic Stem Cell Transplantation

2015 ◽  
Vol 55 (2) ◽  
pp. 109-112
Author(s):  
Hiroaki Tanaka ◽  
Chika Kawajiri ◽  
Shio Sakai ◽  
Yusuke Takeda ◽  
Takeharu Kawaguchi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Function ◽  
Stem Cell Transplantation ◽  
Iron Overload ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation

scholarly journals Comparison of Survival Between Autologous and Allogeneic Stem Cell Transplantation in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma: A Meta-Analysis

2020 ◽  
Vol 29 ◽  
pp. 096368972097539
Author(s):  
Jianhong Wang ◽  
Xiaohui Duan ◽  
Lijie Yang ◽  
Xiangxiang Liu ◽  
Caixia Hao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Meta Analysis ◽  
B Cell Lymphoma ◽  
Free Survival ◽  
Non Hodgkin Lymphoma

This study aimed to compare the efficacy of allogeneic stem cell transplantation (allo-SCT) versus autologous SCT (auto-SCT) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). Medline, CENTRAL, and EMBASE databases through December 31, 2019 were searched. The primary endpoints were overall survival (OS) and progression-free survival (PFS) rates. The secondary outcomes include transplant-related mortality (TRM), event-free survival, relapse/or progression, and nonrelapse mortality (NRM). The 18 retrospective studies enrolled 8,058 B-NHL patients (allo-SCT = 1,204; auto-SCT = 6,854). The OS was significantly higher in patients receiving auto-SCT than allo-SCT (pooled odds ratio [OR]: 1.69, 95% confidence interval [CI]: 1.29 to 2.22, P < 0.001), but no significant difference was found in PFS (pooled OR: 0.98, 95% CI: 0.69 to 1.38, P = 0.891). Auto-SCT patients also had lower TRM and NRM (TRM: OR = 0.23, P < 0.001; NRM: OR = 0.16, P < 0.001), but higher relapse or progression rate (OR = 2.37, P < 0.001) than allo-SCT patients. Subgroup analysis performed for different grades and subtypes of B-NHL showed higher OS in auto-SCT patients with high-grade B-NHL and diffused large B-cell lymphoma (DLBCL). There was, nevertheless, higher PFS in allo-SCT patients with low-grade B-NHL and follicular lymphoma (FL), and lower PFS in allo-SCT patients with DLBCL than their auto-SCT counterparts. In conclusion, the meta-analysis demonstrated that relapsed or refractory B-NHL patients who received auto-SCT have improved OS than those treated with allo-SCT, especially among those with DLBCL, but lower PFS among those with FL. However, the study is limited by a lack of randomized trials, patients’ heterogeneity, and possible selection bias.

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