scholarly journals Pneumatosis Coli Associated to Severe Intestinal Graft Versus Host Disease Following Hematopoietic Cell Transplantation: Risk Factors and Dismal Outcome

2013 ◽  
Vol 19 (2) ◽  
pp. S333 ◽  
Author(s):  
Khaled Guenda ◽  
Jean Roy ◽  
Imran Ahmad ◽  
Lea Bernard ◽  
Sandra Cohen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Pneumatosis Coli ◽  
Host Disease ◽  
Graft Versus Host

Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation

Blood ◽  
2004 ◽  
Vol 104 (6) ◽  
pp. 1894-1897 ◽  
Author(s):  
Kristina M. Adams ◽  
Leona A. Holmberg ◽  
Wendy Leisenring ◽  
Alexander Fefer ◽  
Katherine A. Guthrie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Interleukin 2 ◽  
Hematopoietic Cell ◽  
Independent Effect ◽  
Host Disease ◽  
Graft Versus Host ◽  
Primary Focus

Abstract Syngeneic graft-versus-host disease (sGVHD) has been described after hematopoietic cell transplantation (HCT) but remains poorly defined. We retrospectively reviewed adult syngeneic HCTs at our center (1980-2002) for sGVHD to investigate incidence, morbidity, and risk factors with a primary focus on parity. Among 119 transplantations, there were 21 cases of biopsy-proven sGVHD. The cumulative incidence was 18%, with multiorgan involvement in 6 cases and 1 death. sGVHD was more frequent when the donor was parous (32%) than nulliparous (9%) or male (13%; P = .03) and when the recipient was parous (31%) than nulliparous (7%) or male (13%; P = .02). Other univariable risk factors included older age (P < .01), busulfan/melphalan/thiotepa conditioning (P < .01), interleukin-2 (P = .02), HLA-A26 (P = .03), and more recent transplantation year (P < .01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation.

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